FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034122881> ?p ?o ?g. }

• W2034122881 endingPage "1894" @default.
• W2034122881 startingPage "1890" @default.
• W2034122881 abstract "Serum amyloid A (SAA) is a small (12 kDa) acute-phase apoprotein of high density lipoprotein found in mammals. It is also the precursor to amyloid protein A, the main protein constituent of fibrils found in amyloidosis secondary to chronic or recurrent inflammation--e.g., rheumatoid arthritis. However, rats do not develop amyloidosis and SAA is not an apoprotein of rat high density lipoprotein; thus rats appear to be an exception in regard to expression of SAA genes. We report here that rats do have representatives of the SAA gene family and express two distinct SAA mRNAs. Moreover, the pattern of genes expressed among tissues, and their induction by inflammatory agents, is similar to that of related mouse genes. RNA from various tissues of normal and injured rats was examined by RNA blot hybridization with SAA cDNA and complementary RNA probes for the three murine SAA genes. A SAA mRNA of approximately 400 nucleotides related to mouse SAA1 and SAA2 mRNAs reached a high level in liver 24 hr after injection of bacterial lipopolysaccharide. No extra-hepatic tissues were found to express the SAA1/SAA2-related mRNA. Turpentine induced two hepatic SAA1/SAA2-related mRNAs of approximately 400 and approximately 500 nucleotides in length. Liver SAA1/SAA2-related mRNA hybrid selected and translated in a wheat germ protein-synthesizing system, from lipopolysaccharide- and turpentine-injected rats, produced a single protein with an estimated molecular mass of 8 kDa. This rat liver SAA-related mRNA appears to lack a highly conserved coding region for portions of two amphipathic helical domains and the joining sequence. An mRNA related to mouse SAA3 was found expressed at a high level in lung after lipopolysaccharide but not following turpentine injection. This mRNA was also expressed at high levels in ileum and large intestine of control rats and was not found in the liver of control or challenged rats. These observations show that the SAA gene family is present and expressed in rats and that its expression is found under situations similar to those found in mice. This lends support for the importance of the SAA gene family in the response to injury by vertebrates." @default.
• W2034122881 created "2016-06-24" @default.
• W2034122881 creator A5001024603 @default.
• W2034122881 creator A5038517609 @default.
• W2034122881 date "1989-03-01" @default.
• W2034122881 modified "2023-10-17" @default.
• W2034122881 title "Rat tissues express serum amyloid A protein-related mRNAs." @default.
• W2034122881 cites W1597030361 @default.
• W2034122881 cites W1598873313 @default.
• W2034122881 cites W189101662 @default.
• W2034122881 cites W1969677431 @default.
• W2034122881 cites W1982668809 @default.
• W2034122881 cites W1983563244 @default.
• W2034122881 cites W1986813468 @default.
• W2034122881 cites W1987180168 @default.
• W2034122881 cites W2011836510 @default.
• W2034122881 cites W2015094922 @default.
• W2034122881 cites W2032203651 @default.
• W2034122881 cites W2033299688 @default.
• W2034122881 cites W2034004660 @default.
• W2034122881 cites W2045234497 @default.
• W2034122881 cites W2069860285 @default.
• W2034122881 cites W2075840772 @default.
• W2034122881 cites W2076582359 @default.
• W2034122881 cites W2076807370 @default.
• W2034122881 cites W2077077811 @default.
• W2034122881 cites W2086009573 @default.
• W2034122881 cites W2088986997 @default.
• W2034122881 cites W2094386686 @default.
• W2034122881 cites W2118102036 @default.
• W2034122881 cites W2130888600 @default.
• W2034122881 cites W2136477387 @default.
• W2034122881 cites W2143014493 @default.
• W2034122881 cites W2396687047 @default.
• W2034122881 cites W2400088439 @default.
• W2034122881 cites W2417364584 @default.
• W2034122881 cites W93677944 @default.
• W2034122881 doi "https://doi.org/10.1073/pnas.86.6.1890" @default.
• W2034122881 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/286810" @default.
• W2034122881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2928311" @default.
• W2034122881 hasPublicationYear "1989" @default.
• W2034122881 type Work @default.
• W2034122881 sameAs 2034122881 @default.
• W2034122881 citedByCount "43" @default.
• W2034122881 countsByYear W20341228812012 @default.
• W2034122881 countsByYear W20341228812013 @default.
• W2034122881 countsByYear W20341228812014 @default.
• W2034122881 countsByYear W20341228812017 @default.
• W2034122881 countsByYear W20341228812018 @default.
• W2034122881 countsByYear W20341228812019 @default.
• W2034122881 countsByYear W20341228812021 @default.
• W2034122881 crossrefType "journal-article" @default.
• W2034122881 hasAuthorship W2034122881A5001024603 @default.
• W2034122881 hasAuthorship W2034122881A5038517609 @default.
• W2034122881 hasBestOaLocation W20341228811 @default.
• W2034122881 hasConcept C104317684 @default.
• W2034122881 hasConcept C105580179 @default.
• W2034122881 hasConcept C126322002 @default.
• W2034122881 hasConcept C134018914 @default.
• W2034122881 hasConcept C150194340 @default.
• W2034122881 hasConcept C153911025 @default.
• W2034122881 hasConcept C177707886 @default.
• W2034122881 hasConcept C187882448 @default.
• W2034122881 hasConcept C203014093 @default.
• W2034122881 hasConcept C2776914184 @default.
• W2034122881 hasConcept C2778163477 @default.
• W2034122881 hasConcept C2778754761 @default.
• W2034122881 hasConcept C2779951007 @default.
• W2034122881 hasConcept C2910060150 @default.
• W2034122881 hasConcept C55359608 @default.
• W2034122881 hasConcept C55493867 @default.
• W2034122881 hasConcept C57194454 @default.
• W2034122881 hasConcept C62746215 @default.
• W2034122881 hasConcept C67705224 @default.
• W2034122881 hasConcept C71924100 @default.
• W2034122881 hasConcept C86803240 @default.
• W2034122881 hasConceptScore W2034122881C104317684 @default.
• W2034122881 hasConceptScore W2034122881C105580179 @default.
• W2034122881 hasConceptScore W2034122881C126322002 @default.
• W2034122881 hasConceptScore W2034122881C134018914 @default.
• W2034122881 hasConceptScore W2034122881C150194340 @default.
• W2034122881 hasConceptScore W2034122881C153911025 @default.
• W2034122881 hasConceptScore W2034122881C177707886 @default.
• W2034122881 hasConceptScore W2034122881C187882448 @default.
• W2034122881 hasConceptScore W2034122881C203014093 @default.
• W2034122881 hasConceptScore W2034122881C2776914184 @default.
• W2034122881 hasConceptScore W2034122881C2778163477 @default.
• W2034122881 hasConceptScore W2034122881C2778754761 @default.
• W2034122881 hasConceptScore W2034122881C2779951007 @default.
• W2034122881 hasConceptScore W2034122881C2910060150 @default.
• W2034122881 hasConceptScore W2034122881C55359608 @default.
• W2034122881 hasConceptScore W2034122881C55493867 @default.
• W2034122881 hasConceptScore W2034122881C57194454 @default.
• W2034122881 hasConceptScore W2034122881C62746215 @default.
• W2034122881 hasConceptScore W2034122881C67705224 @default.
• W2034122881 hasConceptScore W2034122881C71924100 @default.
• W2034122881 hasConceptScore W2034122881C86803240 @default.
• W2034122881 hasIssue "6" @default.

• next