Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034122901> ?p ?o ?g. }
- W2034122901 endingPage "233" @default.
- W2034122901 startingPage "224" @default.
- W2034122901 abstract "Molecular systems biology aims to describe the functions of complex biological processes through recursive integration of molecular analysis, modeling, simulation and theory. It focuses on networks that originate from interconnection of genes, proteins and metabolites whose dynamic interactions generate, as an emergent property of the system, the corresponding function. Although evolutionary optimized, intracellular biochemical parameters, such as the expression level of gene products or the affinity between two or more proteins, must have a permissible range that gives robustness against perturbations to the system. Using the yeast G1-to-S transition network as an example we show that sophisticated relations exist among network structure, emergent property and robustness. Different emergent properties are generated from the same network by changing the strength of its interactions, not only by altering expression level, but also through mono and multi-site phosphorylation/dephosphorylation. Besides, multi-site protein phosphorylation modules, widespread in cell cycle, may ensure robust and coherent timing of cell cycle transitions as it happens for the onset of DNA replication. In conclusion, the modulation of biological function/emergent property by modifying interaction strength provides an efficient, highly tunable device to regulate biological processes. Furthermore, the principles outlined herein may provide new insight to network analysis in drug discovery." @default.
- W2034122901 created "2016-06-24" @default.
- W2034122901 creator A5022095447 @default.
- W2034122901 creator A5053427006 @default.
- W2034122901 creator A5063056739 @default.
- W2034122901 date "2009-11-01" @default.
- W2034122901 modified "2023-10-09" @default.
- W2034122901 title "Molecular networks and system-level properties" @default.
- W2034122901 cites W1504533062 @default.
- W2034122901 cites W1504911372 @default.
- W2034122901 cites W1541316156 @default.
- W2034122901 cites W1592521995 @default.
- W2034122901 cites W1637936532 @default.
- W2034122901 cites W1644749979 @default.
- W2034122901 cites W169216998 @default.
- W2034122901 cites W1759539608 @default.
- W2034122901 cites W1844182321 @default.
- W2034122901 cites W1908528408 @default.
- W2034122901 cites W1965976637 @default.
- W2034122901 cites W1971353345 @default.
- W2034122901 cites W1971826720 @default.
- W2034122901 cites W1975471112 @default.
- W2034122901 cites W1975507400 @default.
- W2034122901 cites W1976075923 @default.
- W2034122901 cites W1978486653 @default.
- W2034122901 cites W1979833590 @default.
- W2034122901 cites W1980609967 @default.
- W2034122901 cites W1981849277 @default.
- W2034122901 cites W1986318609 @default.
- W2034122901 cites W1989076816 @default.
- W2034122901 cites W1989921625 @default.
- W2034122901 cites W1995948979 @default.
- W2034122901 cites W1996405087 @default.
- W2034122901 cites W1997091955 @default.
- W2034122901 cites W1998140907 @default.
- W2034122901 cites W1998670024 @default.
- W2034122901 cites W1999001143 @default.
- W2034122901 cites W1999503228 @default.
- W2034122901 cites W2003890287 @default.
- W2034122901 cites W2010707723 @default.
- W2034122901 cites W2011242261 @default.
- W2034122901 cites W2013522363 @default.
- W2034122901 cites W2013771325 @default.
- W2034122901 cites W2013970469 @default.
- W2034122901 cites W2014238063 @default.
- W2034122901 cites W2015519162 @default.
- W2034122901 cites W2018843280 @default.
- W2034122901 cites W2020839855 @default.
- W2034122901 cites W2023490488 @default.
- W2034122901 cites W2023777453 @default.
- W2034122901 cites W2024797223 @default.
- W2034122901 cites W2030165415 @default.
- W2034122901 cites W2030877568 @default.
- W2034122901 cites W2031893066 @default.
- W2034122901 cites W2033711351 @default.
- W2034122901 cites W2035826295 @default.
- W2034122901 cites W2041042514 @default.
- W2034122901 cites W2041652145 @default.
- W2034122901 cites W2045798614 @default.
- W2034122901 cites W2045861560 @default.
- W2034122901 cites W2047746661 @default.
- W2034122901 cites W2048899019 @default.
- W2034122901 cites W2049374704 @default.
- W2034122901 cites W2053096433 @default.
- W2034122901 cites W2053146271 @default.
- W2034122901 cites W2054464331 @default.
- W2034122901 cites W2060497162 @default.
- W2034122901 cites W2064154094 @default.
- W2034122901 cites W2064324413 @default.
- W2034122901 cites W2064441783 @default.
- W2034122901 cites W2069244750 @default.
- W2034122901 cites W2069405322 @default.
- W2034122901 cites W2072389876 @default.
- W2034122901 cites W2072549597 @default.
- W2034122901 cites W2074455942 @default.
- W2034122901 cites W2076712963 @default.
- W2034122901 cites W208070023 @default.
- W2034122901 cites W2081298797 @default.
- W2034122901 cites W2082128798 @default.
- W2034122901 cites W2082371334 @default.
- W2034122901 cites W2082613621 @default.
- W2034122901 cites W2082815621 @default.
- W2034122901 cites W2084426169 @default.
- W2034122901 cites W2084518357 @default.
- W2034122901 cites W2087431768 @default.
- W2034122901 cites W2088127501 @default.
- W2034122901 cites W2092153867 @default.
- W2034122901 cites W2095386748 @default.
- W2034122901 cites W2095883439 @default.
- W2034122901 cites W2097330051 @default.
- W2034122901 cites W2099048878 @default.
- W2034122901 cites W2100485294 @default.
- W2034122901 cites W2105611469 @default.
- W2034122901 cites W2107270569 @default.
- W2034122901 cites W2114136380 @default.
- W2034122901 cites W2114804859 @default.
- W2034122901 cites W2116142329 @default.
- W2034122901 cites W2117056464 @default.