Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034123141> ?p ?o ?g. }
- W2034123141 endingPage "2011" @default.
- W2034123141 startingPage "2005" @default.
- W2034123141 abstract "Marine Chlorella ellipsoidea protein was hydrolyzed using Protamex, Kojizyme, Neutrase, Flavourzyme, Alcalase, trypsin, α-chymotrypsin, pepsin and papain. Alcalase-proteolytic hydrolysate exhibited the highest ACE inhibitory activity among them and was fractionated into three ranges of molecular weight (below 5 kDa, 5–10 kDa and above 10 kDa). The below 5 kDa fraction showed the highest ACE inhibitory activity and was used for subsequent purification steps. During consecutive purification, a potent ACE inhibitory peptide from marine C. ellipsoidea, which was composed of 4 amino acids, Val–Glu–Gly–Tyr (MW: 467.2 Da, IC50 value: 128.4 μM), was isolated. Lineweaver–Burk plots suggest that the peptide purified acts as a competitive inhibitor against ACE and stable against gastrointestinal enzymes of pepsin, trypsin and α-chymotrypsin. Furthermore, antihypertensive effect in spontaneously hypertensive rats (SHRs) also revealed that oral administration of purified peptide can decrease systolic blood pressure significantly. The results suggest that marine C. ellipsoidea would be an attractive raw material for the manufacture of antihypertensive nutraceutical ingredients." @default.
- W2034123141 created "2016-06-24" @default.
- W2034123141 creator A5009446618 @default.
- W2034123141 creator A5014506751 @default.
- W2034123141 creator A5016986169 @default.
- W2034123141 creator A5025650584 @default.
- W2034123141 creator A5032365993 @default.
- W2034123141 creator A5035633538 @default.
- W2034123141 creator A5037284987 @default.
- W2034123141 creator A5037732329 @default.
- W2034123141 creator A5060606349 @default.
- W2034123141 creator A5062826164 @default.
- W2034123141 creator A5063373095 @default.
- W2034123141 creator A5069292897 @default.
- W2034123141 creator A5082206255 @default.
- W2034123141 creator A5091769258 @default.
- W2034123141 date "2012-12-01" @default.
- W2034123141 modified "2023-10-13" @default.
- W2034123141 title "A novel angiotensin I-converting enzyme (ACE) inhibitory peptide from a marine Chlorella ellipsoidea and its antihypertensive effect in spontaneously hypertensive rats" @default.
- W2034123141 cites W1972234685 @default.
- W2034123141 cites W1987000855 @default.
- W2034123141 cites W1987987966 @default.
- W2034123141 cites W1988218309 @default.
- W2034123141 cites W1989178448 @default.
- W2034123141 cites W1991306589 @default.
- W2034123141 cites W1991611551 @default.
- W2034123141 cites W1993385997 @default.
- W2034123141 cites W1997281708 @default.
- W2034123141 cites W2000491344 @default.
- W2034123141 cites W2000503184 @default.
- W2034123141 cites W2002528972 @default.
- W2034123141 cites W2004936779 @default.
- W2034123141 cites W2006874229 @default.
- W2034123141 cites W2010937249 @default.
- W2034123141 cites W2021155760 @default.
- W2034123141 cites W2021618359 @default.
- W2034123141 cites W2026742869 @default.
- W2034123141 cites W2032177813 @default.
- W2034123141 cites W2049066334 @default.
- W2034123141 cites W2054597089 @default.
- W2034123141 cites W2056332036 @default.
- W2034123141 cites W2057908978 @default.
- W2034123141 cites W2066698774 @default.
- W2034123141 cites W2069505065 @default.
- W2034123141 cites W2074866239 @default.
- W2034123141 cites W2078441375 @default.
- W2034123141 cites W2081962247 @default.
- W2034123141 cites W2086441142 @default.
- W2034123141 cites W2093281312 @default.
- W2034123141 cites W2105616599 @default.
- W2034123141 cites W2114311509 @default.
- W2034123141 cites W2115896899 @default.
- W2034123141 cites W2117071648 @default.
- W2034123141 cites W2142347086 @default.
- W2034123141 cites W2200030569 @default.
- W2034123141 cites W93892868 @default.
- W2034123141 doi "https://doi.org/10.1016/j.procbio.2012.07.015" @default.
- W2034123141 hasPublicationYear "2012" @default.
- W2034123141 type Work @default.
- W2034123141 sameAs 2034123141 @default.
- W2034123141 citedByCount "141" @default.
- W2034123141 countsByYear W20341231412013 @default.
- W2034123141 countsByYear W20341231412014 @default.
- W2034123141 countsByYear W20341231412015 @default.
- W2034123141 countsByYear W20341231412016 @default.
- W2034123141 countsByYear W20341231412017 @default.
- W2034123141 countsByYear W20341231412018 @default.
- W2034123141 countsByYear W20341231412019 @default.
- W2034123141 countsByYear W20341231412020 @default.
- W2034123141 countsByYear W20341231412021 @default.
- W2034123141 countsByYear W20341231412022 @default.
- W2034123141 countsByYear W20341231412023 @default.
- W2034123141 crossrefType "journal-article" @default.
- W2034123141 hasAuthorship W2034123141A5009446618 @default.
- W2034123141 hasAuthorship W2034123141A5014506751 @default.
- W2034123141 hasAuthorship W2034123141A5016986169 @default.
- W2034123141 hasAuthorship W2034123141A5025650584 @default.
- W2034123141 hasAuthorship W2034123141A5032365993 @default.
- W2034123141 hasAuthorship W2034123141A5035633538 @default.
- W2034123141 hasAuthorship W2034123141A5037284987 @default.
- W2034123141 hasAuthorship W2034123141A5037732329 @default.
- W2034123141 hasAuthorship W2034123141A5060606349 @default.
- W2034123141 hasAuthorship W2034123141A5062826164 @default.
- W2034123141 hasAuthorship W2034123141A5063373095 @default.
- W2034123141 hasAuthorship W2034123141A5069292897 @default.
- W2034123141 hasAuthorship W2034123141A5082206255 @default.
- W2034123141 hasAuthorship W2034123141A5091769258 @default.
- W2034123141 hasConcept C134018914 @default.
- W2034123141 hasConcept C16311235 @default.
- W2034123141 hasConcept C17857428 @default.
- W2034123141 hasConcept C181199279 @default.
- W2034123141 hasConcept C185592680 @default.
- W2034123141 hasConcept C198710026 @default.
- W2034123141 hasConcept C202751555 @default.
- W2034123141 hasConcept C27016395 @default.
- W2034123141 hasConcept C2776714187 @default.
- W2034123141 hasConcept C2777334355 @default.
- W2034123141 hasConcept C2777752497 @default.