FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034124533> ?p ?o ?g. }

• W2034124533 endingPage "117" @default.
• W2034124533 startingPage "111" @default.
• W2034124533 abstract "Patients with osteoarthritis (OA) suffer from joint pain aggravated by movement, which affect their quality of life. In the present study, a weight bearing paradigm for pain at rest and a gait paradigm for pain during movement were tested in rats with unilateral knee arthritis induced by an intra-articular injection of sodium monoiodoacetate (MIA). At week 3 after MIA (1 mg/knee) injection, animals developed pain-associated, right-left imbalances of weight distribution (weight bearing) or foot print parameters (gait). Diclofenac, at doses up to 30 mg/kg orally (p.o.), did not have a significant effect on either paradigm. Morphine rectified the weight bearing and gait imbalances at 1 and 3 mg/kg subcutaneously, respectively. The weak opioid and serotonin/norepinephrine reuptake inhibitor (SNRI) tramadol also significantly corrected the indices at 10 mg/kg (weight bearing) and 100 mg/kg p.o. (gait). The SNRI duloxetine at 30 mg/kg p.o. corrected the weight bearing imbalance but not gait imbalance. We assessed the effect of different drugs on pain-induced disturbances in weight distribution and gait in MIA-induced arthritic rats. Analgesic drugs, each with different mechanisms of action, were less effective in rectifying the imbalance in gait than that in weight distribution. The assessment of the effect of analgesics on not only rest pain but pain during movement is valuable for the comprehensive examination of their therapeutic efficacies in OA." @default.
• W2034124533 created "2016-06-24" @default.
• W2034124533 creator A5006868583 @default.
• W2034124533 creator A5031445710 @default.
• W2034124533 creator A5038707550 @default.
• W2034124533 creator A5059193816 @default.
• W2034124533 date "2014-09-01" @default.
• W2034124533 modified "2023-10-14" @default.
• W2034124533 title "Efficacy of drugs with different mechanisms of action in relieving spontaneous pain at rest and during movement in a rat model of osteoarthritis" @default.
• W2034124533 cites W1964874409 @default.
• W2034124533 cites W1977334229 @default.
• W2034124533 cites W1980241739 @default.
• W2034124533 cites W1986688831 @default.
• W2034124533 cites W1988682816 @default.
• W2034124533 cites W1991267603 @default.
• W2034124533 cites W2006864238 @default.
• W2034124533 cites W2013445788 @default.
• W2034124533 cites W2016018829 @default.
• W2034124533 cites W2019972898 @default.
• W2034124533 cites W2024898986 @default.
• W2034124533 cites W2035397928 @default.
• W2034124533 cites W2035413305 @default.
• W2034124533 cites W2038089520 @default.
• W2034124533 cites W2039871355 @default.
• W2034124533 cites W2042443179 @default.
• W2034124533 cites W2052607429 @default.
• W2034124533 cites W2060378831 @default.
• W2034124533 cites W2075490888 @default.
• W2034124533 cites W2082756130 @default.
• W2034124533 cites W2083274218 @default.
• W2034124533 cites W2088311820 @default.
• W2034124533 cites W2090998770 @default.
• W2034124533 cites W2095566533 @default.
• W2034124533 cites W2117040516 @default.
• W2034124533 cites W2117916530 @default.
• W2034124533 cites W2132291140 @default.
• W2034124533 cites W2134033828 @default.
• W2034124533 cites W2141391452 @default.
• W2034124533 cites W2146996737 @default.
• W2034124533 cites W2164863281 @default.
• W2034124533 doi "https://doi.org/10.1016/j.ejphar.2014.05.048" @default.
• W2034124533 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24939049" @default.
• W2034124533 hasPublicationYear "2014" @default.
• W2034124533 type Work @default.
• W2034124533 sameAs 2034124533 @default.
• W2034124533 citedByCount "43" @default.
• W2034124533 countsByYear W20341245332015 @default.
• W2034124533 countsByYear W20341245332016 @default.
• W2034124533 countsByYear W20341245332017 @default.
• W2034124533 countsByYear W20341245332018 @default.
• W2034124533 countsByYear W20341245332019 @default.
• W2034124533 countsByYear W20341245332020 @default.
• W2034124533 countsByYear W20341245332021 @default.
• W2034124533 countsByYear W20341245332022 @default.
• W2034124533 countsByYear W20341245332023 @default.
• W2034124533 crossrefType "journal-article" @default.
• W2034124533 hasAuthorship W2034124533A5006868583 @default.
• W2034124533 hasAuthorship W2034124533A5031445710 @default.
• W2034124533 hasAuthorship W2034124533A5038707550 @default.
• W2034124533 hasAuthorship W2034124533A5059193816 @default.
• W2034124533 hasConcept C126322002 @default.
• W2034124533 hasConcept C141071460 @default.
• W2034124533 hasConcept C142724271 @default.
• W2034124533 hasConcept C151800584 @default.
• W2034124533 hasConcept C170493617 @default.
• W2034124533 hasConcept C204787440 @default.
• W2034124533 hasConcept C2776164576 @default.
• W2034124533 hasConcept C2777389121 @default.
• W2034124533 hasConcept C2779777798 @default.
• W2034124533 hasConcept C2780204347 @default.
• W2034124533 hasConcept C2780764818 @default.
• W2034124533 hasConcept C2780820201 @default.
• W2034124533 hasConcept C2781063702 @default.
• W2034124533 hasConcept C42219234 @default.
• W2034124533 hasConcept C71924100 @default.
• W2034124533 hasConcept C99508421 @default.
• W2034124533 hasConceptScore W2034124533C126322002 @default.
• W2034124533 hasConceptScore W2034124533C141071460 @default.
• W2034124533 hasConceptScore W2034124533C142724271 @default.
• W2034124533 hasConceptScore W2034124533C151800584 @default.
• W2034124533 hasConceptScore W2034124533C170493617 @default.
• W2034124533 hasConceptScore W2034124533C204787440 @default.
• W2034124533 hasConceptScore W2034124533C2776164576 @default.
• W2034124533 hasConceptScore W2034124533C2777389121 @default.
• W2034124533 hasConceptScore W2034124533C2779777798 @default.
• W2034124533 hasConceptScore W2034124533C2780204347 @default.
• W2034124533 hasConceptScore W2034124533C2780764818 @default.
• W2034124533 hasConceptScore W2034124533C2780820201 @default.
• W2034124533 hasConceptScore W2034124533C2781063702 @default.
• W2034124533 hasConceptScore W2034124533C42219234 @default.
• W2034124533 hasConceptScore W2034124533C71924100 @default.
• W2034124533 hasConceptScore W2034124533C99508421 @default.
• W2034124533 hasLocation W20341245331 @default.
• W2034124533 hasLocation W20341245332 @default.
• W2034124533 hasOpenAccess W2034124533 @default.
• W2034124533 hasPrimaryLocation W20341245331 @default.
• W2034124533 hasRelatedWork W2017258109 @default.
• W2034124533 hasRelatedWork W2019357946 @default.

• next