FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034125909> ?p ?o ?g. }

• W2034125909 endingPage "1605" @default.
• W2034125909 startingPage "1598" @default.
• W2034125909 abstract "Estrogen receptor (ER) agonists and antagonists elicit distinct responses in non-small cell lung cancer (NSCLC) cells. To determine how such responses are generated, the expression of ERalpha, ERbeta, and ER coregulators in human lung fibroblasts and human NSCLC cell lines was evaluated by immunoblot. Ligand-dependent estrogenic responses in NSCLC cells are probably generated via ERbeta and the p160 coactivator GRIP1/TIF2, because expression of these proteins was detected, but not full-length ERalpha or the p160 coactivator SRC-1. ERbeta and GRIP1/TIF2 are shown to interact in vitro in a ligand-dependent manner and thus may form functional transcription complexes in NSCLC cells. Furthermore, the capacity of ER ligands to regulate gene expression in NSCLC cells was explored using gene miniarrays. Expression profiles were examined after treatment with ER agonist 17-beta-estradiol (E2), the pure ER antagonist ICI 182,780 (fulvestrant, Faslodex), or epidermal growth factor, which served as a positive control for an alternative growth stimulus. E-cadherin and inhibitor of differentiation 2 were differentially regulated by E2 versus ICI 182,780 in 201T and 273T NSCLC cell lines. Epidermal growth factor also stimulated proliferation of these cells but had no effect on expression of E-cadherin and inhibitor of differentiation 2, suggesting they are specific targets of ER signaling. These data show that NSCLC cells respond to estrogens/antiestrogens by altering endogenous gene expression and support a model in which ICI 182,780 reduces proliferation of NSCLC cells via its ability to disrupt ER signaling. ICI 182,780 may therefore have therapeutic benefit in NSCLC." @default.
• W2034125909 created "2016-06-24" @default.
• W2034125909 creator A5000004904 @default.
• W2034125909 creator A5031746829 @default.
• W2034125909 creator A5055771243 @default.
• W2034125909 creator A5070261076 @default.
• W2034125909 creator A5074033631 @default.
• W2034125909 creator A5091879270 @default.
• W2034125909 date "2005-02-15" @default.
• W2034125909 modified "2023-10-01" @default.
• W2034125909 title "Regulation of Endogenous Gene Expression in Human Non–Small Cell Lung Cancer Cells by Estrogen Receptor Ligands" @default.
• W2034125909 cites W1493268813 @default.
• W2034125909 cites W1494515794 @default.
• W2034125909 cites W1622668755 @default.
• W2034125909 cites W1969658446 @default.
• W2034125909 cites W1972158913 @default.
• W2034125909 cites W1974127600 @default.
• W2034125909 cites W2003019920 @default.
• W2034125909 cites W2012155675 @default.
• W2034125909 cites W2017886735 @default.
• W2034125909 cites W2020586541 @default.
• W2034125909 cites W2027167250 @default.
• W2034125909 cites W2030781995 @default.
• W2034125909 cites W2035038116 @default.
• W2034125909 cites W2042602894 @default.
• W2034125909 cites W2045389096 @default.
• W2034125909 cites W2056806829 @default.
• W2034125909 cites W2060128629 @default.
• W2034125909 cites W2062124409 @default.
• W2034125909 cites W2064482843 @default.
• W2034125909 cites W2064776404 @default.
• W2034125909 cites W2068113812 @default.
• W2034125909 cites W2073883348 @default.
• W2034125909 cites W2081725472 @default.
• W2034125909 cites W2082532013 @default.
• W2034125909 cites W2086909267 @default.
• W2034125909 cites W2090897053 @default.
• W2034125909 cites W2091256192 @default.
• W2034125909 cites W2093350076 @default.
• W2034125909 cites W2116865760 @default.
• W2034125909 cites W2121071871 @default.
• W2034125909 cites W2121155074 @default.
• W2034125909 cites W2136333061 @default.
• W2034125909 cites W2145635871 @default.
• W2034125909 cites W2163688875 @default.
• W2034125909 doi "https://doi.org/10.1158/0008-5472.can-04-2694" @default.
• W2034125909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15735050" @default.
• W2034125909 hasPublicationYear "2005" @default.
• W2034125909 type Work @default.
• W2034125909 sameAs 2034125909 @default.
• W2034125909 citedByCount "153" @default.
• W2034125909 countsByYear W20341259092012 @default.
• W2034125909 countsByYear W20341259092013 @default.
• W2034125909 countsByYear W20341259092014 @default.
• W2034125909 countsByYear W20341259092015 @default.
• W2034125909 countsByYear W20341259092016 @default.
• W2034125909 countsByYear W20341259092017 @default.
• W2034125909 countsByYear W20341259092018 @default.
• W2034125909 countsByYear W20341259092019 @default.
• W2034125909 countsByYear W20341259092020 @default.
• W2034125909 countsByYear W20341259092021 @default.
• W2034125909 countsByYear W20341259092022 @default.
• W2034125909 countsByYear W20341259092023 @default.
• W2034125909 crossrefType "journal-article" @default.
• W2034125909 hasAuthorship W2034125909A5000004904 @default.
• W2034125909 hasAuthorship W2034125909A5031746829 @default.
• W2034125909 hasAuthorship W2034125909A5055771243 @default.
• W2034125909 hasAuthorship W2034125909A5070261076 @default.
• W2034125909 hasAuthorship W2034125909A5074033631 @default.
• W2034125909 hasAuthorship W2034125909A5091879270 @default.
• W2034125909 hasBestOaLocation W20341259091 @default.
• W2034125909 hasConcept C104317684 @default.
• W2034125909 hasConcept C121608353 @default.
• W2034125909 hasConcept C126322002 @default.
• W2034125909 hasConcept C134018914 @default.
• W2034125909 hasConcept C2780482068 @default.
• W2034125909 hasConcept C502942594 @default.
• W2034125909 hasConcept C530470458 @default.
• W2034125909 hasConcept C54355233 @default.
• W2034125909 hasConcept C55493867 @default.
• W2034125909 hasConcept C62112901 @default.
• W2034125909 hasConcept C71924100 @default.
• W2034125909 hasConcept C77445288 @default.
• W2034125909 hasConcept C84606932 @default.
• W2034125909 hasConcept C86339819 @default.
• W2034125909 hasConcept C86803240 @default.
• W2034125909 hasConcept C95444343 @default.
• W2034125909 hasConcept C96232424 @default.
• W2034125909 hasConceptScore W2034125909C104317684 @default.
• W2034125909 hasConceptScore W2034125909C121608353 @default.
• W2034125909 hasConceptScore W2034125909C126322002 @default.
• W2034125909 hasConceptScore W2034125909C134018914 @default.
• W2034125909 hasConceptScore W2034125909C2780482068 @default.
• W2034125909 hasConceptScore W2034125909C502942594 @default.
• W2034125909 hasConceptScore W2034125909C530470458 @default.
• W2034125909 hasConceptScore W2034125909C54355233 @default.
• W2034125909 hasConceptScore W2034125909C55493867 @default.
• W2034125909 hasConceptScore W2034125909C62112901 @default.

• next