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- W2034127098 abstract "Dorsal root ganglia from 8-day chick embryos were explanted in semisolid media with or without a specific nerve growth factor (NGF). The ganglia were incubated for a period of 4 and 12 h and examined with the electron microscope. The presence of the NGF in the culture medium calls forth striking and rapid changes in the fine structure of the neurons. The nuclei develop an irregular contour and denser clumped chromatin in comparison with the controls. In the cytoplasm the Golgi apparatus is dilated; in some cells there is a massive increase in ribosomes associated with increased number of membranous elements of endoplasmic reticulum. Neurofilaments and neurotubules, sparse in control cultures, are already prominent after 4 h of incubation in the presence of the NGF. After 12 h, the cytoplasm of most ganglionic cells is packed with large masses of neurofilaments." @default.
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- W2034127098 title "In vitro effects of the nerve growth factor on the fine structure of the sensory nerve cells" @default.
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- W2034127098 doi "https://doi.org/10.1016/0006-8993(68)90054-1" @default.
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