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• W2034127941 abstract "ABSTRACT The similarity of BldG and the downstream coexpressed protein SCO3548 to anti-anti-sigma and anti-sigma factors, respectively, together with the phenotype of a bldG mutant, suggests that BldG and SCO3548 interact as part of a regulatory system to control both antibiotic production and morphological differentiation in Streptomyces coelicolor . A combination of bacterial two-hybrid, affinity purification, and far-Western analyses demonstrated that there was self-interaction of both BldG and SCO3548, as well as a direct interaction between the two proteins. Furthermore, a genetic complementation experiment demonstrated that SCO3548 antagonizes the function of BldG, similar to other anti-anti-sigma/anti-sigma factor pairs. It is therefore proposed that BldG and SCO3548 form a partner-switching pair that regulates the function of one or more sigma factors in S. coelicolor . The conservation of bldG and sco3548 in other streptomycetes demonstrates that this system is likely a key regulatory switch controlling developmental processes throughout the genus Streptomyces ." @default.
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• W2034127941 date "2009-04-15" @default.
• W2034127941 modified "2023-09-30" @default.
• W2034127941 title "BldG and SCO3548 Interact Antagonistically To Control Key Developmental Processes in <i>Streptomyces coelicolor</i>" @default.
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• W2034127941 doi "https://doi.org/10.1128/jb.01695-08" @default.
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