Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034128166> ?p ?o ?g. }
- W2034128166 endingPage "578" @default.
- W2034128166 startingPage "569" @default.
- W2034128166 abstract "M2A antigen is an oncofetal antigen associated with germ cell neoplasia, present in testis on fetal gonocytes and re-expressed on carcinoma in situ (CIS) and germ cell tumours. We developed a panel of monoclonal antibodies (mAb), M2A (IgG2a), D1-26 (IgG2b) and D2-40 (IgG1), to this antigen in order to characterize its structure and study its distribution among germ cell tumours. M2A antigen was purified by sequential lectin and antibody affinity chromatography and characterized as a monomeric M, 40 000 surface sialoglycoprotein, extensively glycosylated with O-linked carbohydrate structures, but devoid of N-linked sugars. Terminal sialic acid residues were required for reactivity with mAb M2A and D1-26, but not D2-40. Sections of 69 testicular germ cell tumours, fixed in formalin and embedded in paraffin, were stained with mAb D2-40 to examine the distribution of M2A antigen. Uniform membrane staining was observed in seminomas, and focal staining in 69% of embryonal carcinomas, 29% of teratomas and 25% of yolk sac tumours. CIS in the vicinity of all germ cell tumours also displayed uniform membrane staining. The characterization of M2A antigen, and the development of mAb which react with it in conventionally preserved archival specimens, provide important initiatives to study the origin and progression of germ cell neoplasia." @default.
- W2034128166 created "2016-06-24" @default.
- W2034128166 creator A5013954759 @default.
- W2034128166 creator A5042022278 @default.
- W2034128166 creator A5042285173 @default.
- W2034128166 creator A5049914982 @default.
- W2034128166 creator A5063824994 @default.
- W2034128166 creator A5064109004 @default.
- W2034128166 creator A5066352197 @default.
- W2034128166 creator A5072910144 @default.
- W2034128166 creator A5091557798 @default.
- W2034128166 date "1999-04-09" @default.
- W2034128166 modified "2023-10-06" @default.
- W2034128166 title "Characterization and distribution of an oncofetal antigen (M2A antigen) expressed on testicular germ cell tumours" @default.
- W2034128166 cites W1480673829 @default.
- W2034128166 cites W1497028439 @default.
- W2034128166 cites W1520382816 @default.
- W2034128166 cites W1528710182 @default.
- W2034128166 cites W1537777030 @default.
- W2034128166 cites W16305166 @default.
- W2034128166 cites W1967326722 @default.
- W2034128166 cites W1994330012 @default.
- W2034128166 cites W2002564923 @default.
- W2034128166 cites W2004862790 @default.
- W2034128166 cites W2007634300 @default.
- W2034128166 cites W2010538502 @default.
- W2034128166 cites W2012218081 @default.
- W2034128166 cites W2021519984 @default.
- W2034128166 cites W2036892782 @default.
- W2034128166 cites W2053308186 @default.
- W2034128166 cites W2054845377 @default.
- W2034128166 cites W2056194550 @default.
- W2034128166 cites W2066011643 @default.
- W2034128166 cites W2073530351 @default.
- W2034128166 cites W2073582279 @default.
- W2034128166 cites W2075589266 @default.
- W2034128166 cites W2083039265 @default.
- W2034128166 cites W2114375886 @default.
- W2034128166 cites W2136418481 @default.
- W2034128166 cites W2146636202 @default.
- W2034128166 cites W2154891352 @default.
- W2034128166 cites W2258362497 @default.
- W2034128166 cites W31349984 @default.
- W2034128166 cites W85331885 @default.
- W2034128166 cites W2131914905 @default.
- W2034128166 doi "https://doi.org/10.1038/sj.bjc.6690393" @default.
- W2034128166 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2362349" @default.
- W2034128166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10408868" @default.
- W2034128166 hasPublicationYear "1999" @default.
- W2034128166 type Work @default.
- W2034128166 sameAs 2034128166 @default.
- W2034128166 citedByCount "243" @default.
- W2034128166 countsByYear W20341281662012 @default.
- W2034128166 countsByYear W20341281662013 @default.
- W2034128166 countsByYear W20341281662014 @default.
- W2034128166 countsByYear W20341281662015 @default.
- W2034128166 countsByYear W20341281662016 @default.
- W2034128166 countsByYear W20341281662017 @default.
- W2034128166 countsByYear W20341281662018 @default.
- W2034128166 countsByYear W20341281662020 @default.
- W2034128166 countsByYear W20341281662021 @default.
- W2034128166 countsByYear W20341281662022 @default.
- W2034128166 countsByYear W20341281662023 @default.
- W2034128166 crossrefType "journal-article" @default.
- W2034128166 hasAuthorship W2034128166A5013954759 @default.
- W2034128166 hasAuthorship W2034128166A5042022278 @default.
- W2034128166 hasAuthorship W2034128166A5042285173 @default.
- W2034128166 hasAuthorship W2034128166A5049914982 @default.
- W2034128166 hasAuthorship W2034128166A5063824994 @default.
- W2034128166 hasAuthorship W2034128166A5064109004 @default.
- W2034128166 hasAuthorship W2034128166A5066352197 @default.
- W2034128166 hasAuthorship W2034128166A5072910144 @default.
- W2034128166 hasAuthorship W2034128166A5091557798 @default.
- W2034128166 hasBestOaLocation W20341281661 @default.
- W2034128166 hasConcept C104317684 @default.
- W2034128166 hasConcept C142724271 @default.
- W2034128166 hasConcept C147483822 @default.
- W2034128166 hasConcept C153911025 @default.
- W2034128166 hasConcept C159654299 @default.
- W2034128166 hasConcept C185592680 @default.
- W2034128166 hasConcept C196843134 @default.
- W2034128166 hasConcept C203014093 @default.
- W2034128166 hasConcept C2776694085 @default.
- W2034128166 hasConcept C2776869981 @default.
- W2034128166 hasConcept C2776938808 @default.
- W2034128166 hasConcept C2777043721 @default.
- W2034128166 hasConcept C2778074268 @default.
- W2034128166 hasConcept C2779122487 @default.
- W2034128166 hasConcept C2780175098 @default.
- W2034128166 hasConcept C2780758401 @default.
- W2034128166 hasConcept C3019217517 @default.
- W2034128166 hasConcept C542903549 @default.
- W2034128166 hasConcept C54355233 @default.
- W2034128166 hasConcept C55493867 @default.
- W2034128166 hasConcept C71924100 @default.
- W2034128166 hasConcept C86803240 @default.
- W2034128166 hasConcept C95444343 @default.
- W2034128166 hasConceptScore W2034128166C104317684 @default.