FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034128970> ?p ?o ?g. }

• W2034128970 endingPage "80" @default.
• W2034128970 startingPage "75" @default.
• W2034128970 abstract "Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with complex genetic inheritance. Many reports have provided evidence that signal transducer and activator of transcription-4 (STAT4) may participate in the pathogenesis of SLE. The aim was to investigate the clinical significance and possible association of STAT4 (G/T) genetic polymorphism and the susceptibility to SLE in a cohort of Egyptian female patients. Sixty-five Egyptian SLE female patients and 100 age and sex-matched unrelated female healthy blood donors who served as controls, were included in the study. STAT4 genotyping was performed by real time PCR-allelic discrimination technique. STAT4 genotyping in patients revealed that 63.1% had GG, 32.3% GT and 6.15% wild (TT) genotype. There was a non-significant difference in the distribution of STAT4 genotypes between patients and controls. Vasculitis, photosensitivity and lupus nephritis were significantly increased in patients with the homomutant (GG and TT) compared to heteromutant (GT) genotype (p = 0.01, p = 0.04 and p < 0.01 respectively). Patients with a TT genotype had a significantly consumed C3 and C4 levels and higher anti-dsDNA positivity compared to those with GG and GT genotypes. Promoter polymorphism tended to be higher in juvenile-onset SLE cases. STAT4 (G/T) polymorphism was not associated with an increased risk of SLE in Egyptian females. However, vasculitis, photosensitivity and renal involvement were significantly higher among patients harboring the homomutant genotypes. Genetic polymorphism may be an important determinant affecting disease progression and is associated with DNA positivity and younger age of onset." @default.
• W2034128970 created "2016-06-24" @default.
• W2034128970 creator A5071399230 @default.
• W2034128970 creator A5077697074 @default.
• W2034128970 creator A5081711456 @default.
• W2034128970 creator A5090401838 @default.
• W2034128970 creator A5090614957 @default.
• W2034128970 date "2015-04-01" @default.
• W2034128970 modified "2023-10-05" @default.
• W2034128970 title "Signal transducer and activator of transcription 4 (STAT4) G/T gene polymorphism in Egyptian systemic lupus erythematosus female patients" @default.
• W2034128970 cites W1537063289 @default.
• W2034128970 cites W1590951668 @default.
• W2034128970 cites W1598692059 @default.
• W2034128970 cites W1617051480 @default.
• W2034128970 cites W1976803657 @default.
• W2034128970 cites W1979897867 @default.
• W2034128970 cites W1998127539 @default.
• W2034128970 cites W2002958926 @default.
• W2034128970 cites W2004706121 @default.
• W2034128970 cites W2011330261 @default.
• W2034128970 cites W2013409933 @default.
• W2034128970 cites W2016787148 @default.
• W2034128970 cites W2026586312 @default.
• W2034128970 cites W2026819380 @default.
• W2034128970 cites W2031355052 @default.
• W2034128970 cites W2038243216 @default.
• W2034128970 cites W2040759013 @default.
• W2034128970 cites W2044723936 @default.
• W2034128970 cites W2048791273 @default.
• W2034128970 cites W2051925328 @default.
• W2034128970 cites W2064999867 @default.
• W2034128970 cites W2078490531 @default.
• W2034128970 cites W2085267757 @default.
• W2034128970 cites W2088462000 @default.
• W2034128970 cites W2088503266 @default.
• W2034128970 cites W2094328608 @default.
• W2034128970 cites W2100336973 @default.
• W2034128970 cites W2137367392 @default.
• W2034128970 cites W2146669607 @default.
• W2034128970 cites W2158300364 @default.
• W2034128970 cites W2159860161 @default.
• W2034128970 cites W2169432046 @default.
• W2034128970 cites W2171897475 @default.
• W2034128970 cites W2886978647 @default.
• W2034128970 doi "https://doi.org/10.1016/j.ejr.2014.07.004" @default.
• W2034128970 hasPublicationYear "2015" @default.
• W2034128970 type Work @default.
• W2034128970 sameAs 2034128970 @default.
• W2034128970 citedByCount "6" @default.
• W2034128970 countsByYear W20341289702015 @default.
• W2034128970 countsByYear W20341289702016 @default.
• W2034128970 countsByYear W20341289702017 @default.
• W2034128970 countsByYear W20341289702018 @default.
• W2034128970 countsByYear W20341289702023 @default.
• W2034128970 crossrefType "journal-article" @default.
• W2034128970 hasAuthorship W2034128970A5071399230 @default.
• W2034128970 hasAuthorship W2034128970A5077697074 @default.
• W2034128970 hasAuthorship W2034128970A5081711456 @default.
• W2034128970 hasAuthorship W2034128970A5090401838 @default.
• W2034128970 hasAuthorship W2034128970A5090614957 @default.
• W2034128970 hasBestOaLocation W20341289701 @default.
• W2034128970 hasConcept C104317684 @default.
• W2034128970 hasConcept C126322002 @default.
• W2034128970 hasConcept C135763542 @default.
• W2034128970 hasConcept C149737253 @default.
• W2034128970 hasConcept C203014093 @default.
• W2034128970 hasConcept C2776015282 @default.
• W2034128970 hasConcept C2777058396 @default.
• W2034128970 hasConcept C2778277574 @default.
• W2034128970 hasConcept C2778923194 @default.
• W2034128970 hasConcept C2779134260 @default.
• W2034128970 hasConcept C2779912601 @default.
• W2034128970 hasConcept C31467283 @default.
• W2034128970 hasConcept C54355233 @default.
• W2034128970 hasConcept C65439459 @default.
• W2034128970 hasConcept C71924100 @default.
• W2034128970 hasConcept C86803240 @default.
• W2034128970 hasConcept C90924648 @default.
• W2034128970 hasConceptScore W2034128970C104317684 @default.
• W2034128970 hasConceptScore W2034128970C126322002 @default.
• W2034128970 hasConceptScore W2034128970C135763542 @default.
• W2034128970 hasConceptScore W2034128970C149737253 @default.
• W2034128970 hasConceptScore W2034128970C203014093 @default.
• W2034128970 hasConceptScore W2034128970C2776015282 @default.
• W2034128970 hasConceptScore W2034128970C2777058396 @default.
• W2034128970 hasConceptScore W2034128970C2778277574 @default.
• W2034128970 hasConceptScore W2034128970C2778923194 @default.
• W2034128970 hasConceptScore W2034128970C2779134260 @default.
• W2034128970 hasConceptScore W2034128970C2779912601 @default.
• W2034128970 hasConceptScore W2034128970C31467283 @default.
• W2034128970 hasConceptScore W2034128970C54355233 @default.
• W2034128970 hasConceptScore W2034128970C65439459 @default.
• W2034128970 hasConceptScore W2034128970C71924100 @default.
• W2034128970 hasConceptScore W2034128970C86803240 @default.
• W2034128970 hasConceptScore W2034128970C90924648 @default.
• W2034128970 hasIssue "2" @default.
• W2034128970 hasLocation W20341289701 @default.
• W2034128970 hasOpenAccess W2034128970 @default.

• next