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- W2034129246 abstract "Previous studies showed that TP inhibits tissue heme oxygenase activity (HO) and lowers serum total bilirubin levels [B], but does not effect the VeCO of neonatal rats with and without artificially created hematomas (H). It is possible that intestinal bacteria play a role in this model by metabolizing excreted heme to CO. Rat litters, with intestines sterilized by antibiotics, were divided into 3 groups of 3 rats each. At 12 h postpartum (t=0), the TP/H rats were injected with TP (65 μmoles/kg). Hematomas were given to H and TP/H rats (t=45 h). Rats were sacrificed at t=113 h. The [B] of the TP/H rats was not reduced, but hepatic HO activity was suppressed (p < .005) when compared to the H control group. The overall average VeCO of H rats was increased by ∼ 45% over S rats and TP was effective in delaying and suppressing this increase; the inhibition of average VeCO was ∼ 25%. The results suggest that in antibiotic-treated rats with artificial hematomas: 1) single dose TP was effective in lowering VeCO and thus total bilirubin formation and 2) intestinal bacteria may contribute significantly to VeCO, if endogenous heme degradation is inhibited." @default.
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- W2034129246 date "1985-04-01" @default.
- W2034129246 modified "2023-09-26" @default.
- W2034129246 title "1486 TIN PROTOPORPHYRIN (TP) AND THE EXCRETION RATE OF CO (VeCO) IN ANTIBIOTIC-TREATED NEONATAL RATS WITH ARTIFICIAL HEMATOMAS" @default.
- W2034129246 doi "https://doi.org/10.1203/00006450-198504000-01510" @default.
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