FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034132414> ?p ?o ?g. }

• W2034132414 endingPage "213" @default.
• W2034132414 startingPage "202" @default.
• W2034132414 abstract "Dietary antioxidants, such as the carotenoids, may protect DNA from oxidative damage. This has been proposed to explain the epidemiological association between higher consumption of fruits and vegetables, which are rich in antioxidants, and lower incidence of cancer. However, this remains to be demonstrated conclusively. The effects of carotenoid supplementation on 1) baseline DNA damage, 2) susceptibility of cellular DNA to oxidative attack, and 3) DNA repair were measured in the human lymphocyte cell line Molt-17. Baseline DNA damage, susceptibility to oxidant attack (100 mumol/l H2O2 for 5 min at 4 degrees C), and disappearance of DNA single-strand breaks (SSB) after oxidative challenge were monitored by single-cell gel electrophoresis. DNA repair patch synthesis activity in cell extracts was determined using assays that measure nucleotide incorporation during repair of oxidative lesions in template DNA. Unlike single-cell gel electrophoresis, the parameters measured with these assays are not dependent on strand break religation. There was no evidence that beta-carotene, lutein, or beta-cryptoxanthin supplementation protected cellular DNA from oxidation under basal conditions or after oxidative challenge. However, only carotenoid-supplemented cells exhibited a significant decrease in numbers of SSB over a 2-h period after treatment with H2O2. Carotenoid supplementation did not provoke any detectable change in repair patch synthesis activity. We conclude that supplementation with carotenoids at 8 mumol/l does not provide significant antioxidant protection for DNA in Molt-17 lymphocytes but may enhance recovery of cells from oxidative challenge, as measured by loss of SSB. We argue that these data are most consistent with carotenoids acting to enhance DNA strand break repair." @default.
• W2034132414 created "2016-06-24" @default.
• W2034132414 creator A5003164682 @default.
• W2034132414 creator A5033651373 @default.
• W2034132414 creator A5053036834 @default.
• W2034132414 creator A5080594671 @default.
• W2034132414 date "2002-07-01" @default.
• W2034132414 modified "2023-09-24" @default.
• W2034132414 title "Increased Cellular Carotenoid Levels Reduce the Persistence of DNA Single-Strand Breaks After Oxidative Challenge" @default.
• W2034132414 cites W1952543526 @default.
• W2034132414 cites W1968310913 @default.
• W2034132414 cites W1969534808 @default.
• W2034132414 cites W1974762401 @default.
• W2034132414 cites W1975860046 @default.
• W2034132414 cites W1976911231 @default.
• W2034132414 cites W1977263017 @default.
• W2034132414 cites W1991455005 @default.
• W2034132414 cites W1997618919 @default.
• W2034132414 cites W2003315786 @default.
• W2034132414 cites W2003567663 @default.
• W2034132414 cites W2025546384 @default.
• W2034132414 cites W2026958200 @default.
• W2034132414 cites W2034562422 @default.
• W2034132414 cites W2046327485 @default.
• W2034132414 cites W2057099897 @default.
• W2034132414 cites W2063573579 @default.
• W2034132414 cites W2065680431 @default.
• W2034132414 cites W2072528535 @default.
• W2034132414 cites W2075092102 @default.
• W2034132414 cites W2104011879 @default.
• W2034132414 cites W2117767912 @default.
• W2034132414 cites W2126902508 @default.
• W2034132414 cites W2133926731 @default.
• W2034132414 cites W2145119829 @default.
• W2034132414 cites W2153017264 @default.
• W2034132414 cites W2153596348 @default.
• W2034132414 cites W2164490838 @default.
• W2034132414 cites W2164613158 @default.
• W2034132414 cites W2320706326 @default.
• W2034132414 cites W2735688748 @default.
• W2034132414 cites W4239462153 @default.
• W2034132414 cites W4240883875 @default.
• W2034132414 cites W4252618611 @default.
• W2034132414 doi "https://doi.org/10.1207/s15327914nc432_11" @default.
• W2034132414 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12588700" @default.
• W2034132414 hasPublicationYear "2002" @default.
• W2034132414 type Work @default.
• W2034132414 sameAs 2034132414 @default.
• W2034132414 citedByCount "27" @default.
• W2034132414 countsByYear W20341324142012 @default.
• W2034132414 countsByYear W20341324142013 @default.
• W2034132414 countsByYear W20341324142014 @default.
• W2034132414 countsByYear W20341324142015 @default.
• W2034132414 countsByYear W20341324142018 @default.
• W2034132414 countsByYear W20341324142019 @default.
• W2034132414 countsByYear W20341324142023 @default.
• W2034132414 crossrefType "journal-article" @default.
• W2034132414 hasAuthorship W2034132414A5003164682 @default.
• W2034132414 hasAuthorship W2034132414A5033651373 @default.
• W2034132414 hasAuthorship W2034132414A5053036834 @default.
• W2034132414 hasAuthorship W2034132414A5080594671 @default.
• W2034132414 hasConcept C116084860 @default.
• W2034132414 hasConcept C134935766 @default.
• W2034132414 hasConcept C143425029 @default.
• W2034132414 hasConcept C153911025 @default.
• W2034132414 hasConcept C2776151105 @default.
• W2034132414 hasConcept C2778004101 @default.
• W2034132414 hasConcept C2778411929 @default.
• W2034132414 hasConcept C28781525 @default.
• W2034132414 hasConcept C552990157 @default.
• W2034132414 hasConcept C55493867 @default.
• W2034132414 hasConcept C57600042 @default.
• W2034132414 hasConcept C86803240 @default.
• W2034132414 hasConceptScore W2034132414C116084860 @default.
• W2034132414 hasConceptScore W2034132414C134935766 @default.
• W2034132414 hasConceptScore W2034132414C143425029 @default.
• W2034132414 hasConceptScore W2034132414C153911025 @default.
• W2034132414 hasConceptScore W2034132414C2776151105 @default.
• W2034132414 hasConceptScore W2034132414C2778004101 @default.
• W2034132414 hasConceptScore W2034132414C2778411929 @default.
• W2034132414 hasConceptScore W2034132414C28781525 @default.
• W2034132414 hasConceptScore W2034132414C552990157 @default.
• W2034132414 hasConceptScore W2034132414C55493867 @default.
• W2034132414 hasConceptScore W2034132414C57600042 @default.
• W2034132414 hasConceptScore W2034132414C86803240 @default.
• W2034132414 hasIssue "2" @default.
• W2034132414 hasLocation W20341324141 @default.
• W2034132414 hasLocation W20341324142 @default.
• W2034132414 hasOpenAccess W2034132414 @default.
• W2034132414 hasPrimaryLocation W20341324141 @default.
• W2034132414 hasRelatedWork W1749282746 @default.
• W2034132414 hasRelatedWork W2017599934 @default.
• W2034132414 hasRelatedWork W2029386460 @default.
• W2034132414 hasRelatedWork W2030708082 @default.
• W2034132414 hasRelatedWork W2031925581 @default.
• W2034132414 hasRelatedWork W2036419005 @default.
• W2034132414 hasRelatedWork W2119286137 @default.
• W2034132414 hasRelatedWork W2501500029 @default.

• next