FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034132575> ?p ?o ?g. }

• W2034132575 endingPage "2321" @default.
• W2034132575 startingPage "2311" @default.
• W2034132575 abstract "In many parts of the developing nervous system, the early patterns of connectivity are refined by processes that require neuronal activity. These processes are thought to involve Hebbian mechanisms that lead to strengthening and maintenance of inputs that display correlated pre- and postsynaptic activity and elimination of inputs that fire asynchronously. Here we investigated the role of patterned spontaneous retinal activity and Hebbian synaptic mechanisms on segregation of ON and OFF retinal afferents in the dorsal lateral geniculate nucleus (dLGN) of the developing ferret visual system. We recorded extracellularly the spontaneous spike activity of neighboring pairs of ganglion cells and found that OFF cells have significantly higher mean firing rates than ON cells. Spiking is best correlated between cells of the same sign (ON, ON; OFF, OFF) compared with cells of opposite sign (ON, OFF). We then constructed a simple Hebbian model of retinogeniculate synaptic development based on a correlational framework. Using our recorded activity patterns, together with previous calcium-imaging data, we show that endogenous retinal activity, coupled with Hebbian mechanisms of synaptic development, can drive the segregation of ON and OFF retinal inputs to the dLGN. Segregation occurs robustly when heterosynaptic competition is present within time windows of 50-500 ms. In addition, our results suggest that the initial patterns of connectivity (biases in convergence of inputs) and the strength of inhibition in the network each play a crucial role in determining whether ON or OFF inputs dominate at maturity." @default.
• W2034132575 created "2016-06-24" @default.
• W2034132575 creator A5004633766 @default.
• W2034132575 creator A5045996745 @default.
• W2034132575 creator A5063276804 @default.
• W2034132575 date "2002-11-01" @default.
• W2034132575 modified "2023-10-10" @default.
• W2034132575 title "Segregation of <scp>on</scp> and <scp>off</scp>Retinogeniculate Connectivity Directed by Patterned Spontaneous Activity" @default.
• W2034132575 cites W1486852018 @default.
• W2034132575 cites W1596533183 @default.
• W2034132575 cites W1612231323 @default.
• W2034132575 cites W1628660012 @default.
• W2034132575 cites W1733248925 @default.
• W2034132575 cites W1751495803 @default.
• W2034132575 cites W180047018 @default.
• W2034132575 cites W1817006636 @default.
• W2034132575 cites W1865428056 @default.
• W2034132575 cites W1978596696 @default.
• W2034132575 cites W1979466236 @default.
• W2034132575 cites W2012949356 @default.
• W2034132575 cites W2013683059 @default.
• W2034132575 cites W2019203033 @default.
• W2034132575 cites W2023051360 @default.
• W2034132575 cites W2030963909 @default.
• W2034132575 cites W2032325265 @default.
• W2034132575 cites W2039347674 @default.
• W2034132575 cites W2057050792 @default.
• W2034132575 cites W2065546903 @default.
• W2034132575 cites W2066146783 @default.
• W2034132575 cites W2068851283 @default.
• W2034132575 cites W2069306062 @default.
• W2034132575 cites W2074942478 @default.
• W2034132575 cites W2081829215 @default.
• W2034132575 cites W2083579647 @default.
• W2034132575 cites W2085287004 @default.
• W2034132575 cites W2087103619 @default.
• W2034132575 cites W2089178397 @default.
• W2034132575 cites W2096473662 @default.
• W2034132575 cites W2122925692 @default.
• W2034132575 cites W2123820663 @default.
• W2034132575 cites W2131170352 @default.
• W2034132575 cites W2133542713 @default.
• W2034132575 cites W2133776755 @default.
• W2034132575 cites W2134376523 @default.
• W2034132575 cites W2134505400 @default.
• W2034132575 cites W2147101007 @default.
• W2034132575 cites W2150947099 @default.
• W2034132575 cites W2151788312 @default.
• W2034132575 cites W2165746994 @default.
• W2034132575 cites W2167385808 @default.
• W2034132575 cites W2171406132 @default.
• W2034132575 cites W2171490281 @default.
• W2034132575 cites W2207079540 @default.
• W2034132575 cites W2185212694 @default.
• W2034132575 doi "https://doi.org/10.1152/jn.00372.2002" @default.
• W2034132575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12424272" @default.
• W2034132575 hasPublicationYear "2002" @default.
• W2034132575 type Work @default.
• W2034132575 sameAs 2034132575 @default.
• W2034132575 citedByCount "39" @default.
• W2034132575 countsByYear W20341325752012 @default.
• W2034132575 countsByYear W20341325752013 @default.
• W2034132575 countsByYear W20341325752014 @default.
• W2034132575 countsByYear W20341325752015 @default.
• W2034132575 countsByYear W20341325752019 @default.
• W2034132575 countsByYear W20341325752020 @default.
• W2034132575 countsByYear W20341325752021 @default.
• W2034132575 countsByYear W20341325752022 @default.
• W2034132575 countsByYear W20341325752023 @default.
• W2034132575 crossrefType "journal-article" @default.
• W2034132575 hasAuthorship W2034132575A5004633766 @default.
• W2034132575 hasAuthorship W2034132575A5045996745 @default.
• W2034132575 hasAuthorship W2034132575A5063276804 @default.
• W2034132575 hasConcept C111437709 @default.
• W2034132575 hasConcept C133529732 @default.
• W2034132575 hasConcept C154945302 @default.
• W2034132575 hasConcept C159919123 @default.
• W2034132575 hasConcept C169760540 @default.
• W2034132575 hasConcept C170493617 @default.
• W2034132575 hasConcept C185592680 @default.
• W2034132575 hasConcept C197341189 @default.
• W2034132575 hasConcept C2777093970 @default.
• W2034132575 hasConcept C2777624874 @default.
• W2034132575 hasConcept C2780827179 @default.
• W2034132575 hasConcept C38137364 @default.
• W2034132575 hasConcept C41008148 @default.
• W2034132575 hasConcept C50644808 @default.
• W2034132575 hasConcept C55493867 @default.
• W2034132575 hasConcept C86803240 @default.
• W2034132575 hasConceptScore W2034132575C111437709 @default.
• W2034132575 hasConceptScore W2034132575C133529732 @default.
• W2034132575 hasConceptScore W2034132575C154945302 @default.
• W2034132575 hasConceptScore W2034132575C159919123 @default.
• W2034132575 hasConceptScore W2034132575C169760540 @default.
• W2034132575 hasConceptScore W2034132575C170493617 @default.
• W2034132575 hasConceptScore W2034132575C185592680 @default.
• W2034132575 hasConceptScore W2034132575C197341189 @default.
• W2034132575 hasConceptScore W2034132575C2777093970 @default.

• next