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- W2034132625 abstract "Abstract 1. 1. Hexadimethrine bromide was tested on the circulatory system of anesthetized dogs and rats, on alimentary lipemia in dogs, on isolated smooth muscle preparations, and on tissue mast cells of rats. 2. 2. Neither lysergic acid diethylamide (LSD), atropine, tripelennamine, chlorcyclizine, LSD plus promethazine, nor double vagotomy was able to block the initial drop in blood pressure caused by hexadimethrine. 3. 3. The initial suppressive effect of hexadimethrine on the circulatory responses of epinephrine, acetylcholine, and histamine was followed by either a secondary return to control levels or by an enhancement of their blood pressure responses. 4. 4. Hexadimethrine, itself a spasmogen, augmented the contractions induced by either acetylcholine, histamine, or serotonin on the rabbit and guinea pig intestinal strips and on the rat uterus. 5. 5. Hexadimethrine caused an increase in visible lipemia when injected into lipemic dogs; it did not cause lipemia in normal fasting dogs. 6. 6. Greater disruption of tissue mast cells occurred with protamine sulfate than with hexadimethrine bromide, both in vitro and in vivo." @default.
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- W2034132625 date "1959-11-01" @default.
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- W2034132625 title "Further studies on hexadimethrine bromide (polybrene)—an antiheparin agent" @default.
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- W2034132625 doi "https://doi.org/10.1016/0041-008x(59)90059-6" @default.
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