FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034133667> ?p ?o ?g. }

• W2034133667 endingPage "585" @default.
• W2034133667 startingPage "578" @default.
• W2034133667 abstract "5-Lipoxygenase (5-LO) products have been strongly implicated in the pathogenesis of allergic diseases. In addition to their physiologic effects on residential cells, 5-LO products are capable of stimulating various eosinophil functions. However, little is known regarding the effects of 5-LO products on basophil functions.This study was designed to elucidate the effects of the main 5-LO products (ie, leukotriene [LT] B(4), LTD(4), and 5-oxo-6,8,11,14-eicosatetraenoic acid [5-oxo-ETE]), as well as their receptor expression on human basophils.We studied the effects of 5-LO products on Ca(2+) mobilization, migration, CD 11b expression, and degranulation of human basophils. Expression of the receptors for LTC(4)/D(4)/E(4) (cysteinyl leukotriene 1 [CysLT(1)] and CysLT(2)), LTB4 (BLT(1) and BLT(2)), and 5-oxo-ETE (oxoeicosanoid [OXE]) was assessed by means of real-time PCR and flow cytometry.At the mRNA level, basophils strongly expressed OXE and predominantly expressed CysLT(1) and BLT(2). The expression level of OXE mRNA in basophils was approximately 20-fold higher than in neutrophils and similar to that in eosinophils. At the protein level, basophils expressed CysLT(1), CysLT(2), BLT(1), and OXE, but not BLT(2). All products elicited a transient increase of cytosolic calcium, with the order of magnitude being LTB(4)>5-oxo-ETE>LTD(4). 5-Oxo-ETE induced a strong basophil migratory response that was almost equivalent to that of prostaglandin D(2). LTB(4) elicited significant degranulation of IL-3-primed basophils. In contrast, no functional significance was observed for LTD(4).Among 5-LO products, 5-oxo-ETE induces a potent basophil migratory response, and LTB(4) elicits degranulation under certain conditions. Our results strongly suggest that 5-oxo-ETE might afford opportunities for therapeutic targeting in allergic inflammation." @default.
• W2034133667 created "2016-06-24" @default.
• W2034133667 creator A5005730268 @default.
• W2034133667 creator A5009023927 @default.
• W2034133667 creator A5026452247 @default.
• W2034133667 creator A5039946811 @default.
• W2034133667 creator A5054668950 @default.
• W2034133667 creator A5062065765 @default.
• W2034133667 creator A5063852123 @default.
• W2034133667 creator A5075284186 @default.
• W2034133667 creator A5077813748 @default.
• W2034133667 creator A5084949750 @default.
• W2034133667 date "2005-09-01" @default.
• W2034133667 modified "2023-10-01" @default.
• W2034133667 title "5-Lipoxygenase products regulate basophil functions: 5-Oxo-ETE elicits migration, and leukotriene B4 induces degranulation" @default.
• W2034133667 cites W1502639397 @default.
• W2034133667 cites W1676806089 @default.
• W2034133667 cites W1967781579 @default.
• W2034133667 cites W1969129517 @default.
• W2034133667 cites W1973517527 @default.
• W2034133667 cites W1998578564 @default.
• W2034133667 cites W2002331449 @default.
• W2034133667 cites W2003689886 @default.
• W2034133667 cites W2017493172 @default.
• W2034133667 cites W2026086105 @default.
• W2034133667 cites W2030634089 @default.
• W2034133667 cites W2033110553 @default.
• W2034133667 cites W2033318972 @default.
• W2034133667 cites W2042381527 @default.
• W2034133667 cites W2045915905 @default.
• W2034133667 cites W2052229593 @default.
• W2034133667 cites W2065373406 @default.
• W2034133667 cites W2070804540 @default.
• W2034133667 cites W2083610245 @default.
• W2034133667 cites W2087584115 @default.
• W2034133667 cites W2091148256 @default.
• W2034133667 cites W2106327430 @default.
• W2034133667 cites W2125166909 @default.
• W2034133667 cites W2135681037 @default.
• W2034133667 cites W2150091654 @default.
• W2034133667 cites W2157310506 @default.
• W2034133667 cites W2166132450 @default.
• W2034133667 cites W2166893697 @default.
• W2034133667 cites W2168203007 @default.
• W2034133667 cites W2169125588 @default.
• W2034133667 doi "https://doi.org/10.1016/j.jaci.2005.04.029" @default.
• W2034133667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16159627" @default.
• W2034133667 hasPublicationYear "2005" @default.
• W2034133667 type Work @default.
• W2034133667 sameAs 2034133667 @default.
• W2034133667 citedByCount "35" @default.
• W2034133667 countsByYear W20341336672013 @default.
• W2034133667 countsByYear W20341336672014 @default.
• W2034133667 countsByYear W20341336672015 @default.
• W2034133667 countsByYear W20341336672016 @default.
• W2034133667 countsByYear W20341336672017 @default.
• W2034133667 countsByYear W20341336672018 @default.
• W2034133667 countsByYear W20341336672019 @default.
• W2034133667 countsByYear W20341336672020 @default.
• W2034133667 countsByYear W20341336672021 @default.
• W2034133667 countsByYear W20341336672022 @default.
• W2034133667 crossrefType "journal-article" @default.
• W2034133667 hasAuthorship W2034133667A5005730268 @default.
• W2034133667 hasAuthorship W2034133667A5009023927 @default.
• W2034133667 hasAuthorship W2034133667A5026452247 @default.
• W2034133667 hasAuthorship W2034133667A5039946811 @default.
• W2034133667 hasAuthorship W2034133667A5054668950 @default.
• W2034133667 hasAuthorship W2034133667A5062065765 @default.
• W2034133667 hasAuthorship W2034133667A5063852123 @default.
• W2034133667 hasAuthorship W2034133667A5075284186 @default.
• W2034133667 hasAuthorship W2034133667A5077813748 @default.
• W2034133667 hasAuthorship W2034133667A5084949750 @default.
• W2034133667 hasBestOaLocation W20341336671 @default.
• W2034133667 hasConcept C141105273 @default.
• W2034133667 hasConcept C159654299 @default.
• W2034133667 hasConcept C170493617 @default.
• W2034133667 hasConcept C181199279 @default.
• W2034133667 hasConcept C185592680 @default.
• W2034133667 hasConcept C203014093 @default.
• W2034133667 hasConcept C2776042228 @default.
• W2034133667 hasConcept C2776452501 @default.
• W2034133667 hasConcept C2776685179 @default.
• W2034133667 hasConcept C2776914184 @default.
• W2034133667 hasConcept C2777037409 @default.
• W2034133667 hasConcept C2777361909 @default.
• W2034133667 hasConcept C2777456892 @default.
• W2034133667 hasConcept C2778078955 @default.
• W2034133667 hasConcept C2779176990 @default.
• W2034133667 hasConcept C2779543280 @default.
• W2034133667 hasConcept C49802076 @default.
• W2034133667 hasConcept C553184892 @default.
• W2034133667 hasConcept C55493867 @default.
• W2034133667 hasConcept C86803240 @default.
• W2034133667 hasConcept C90342290 @default.
• W2034133667 hasConcept C95444343 @default.
• W2034133667 hasConceptScore W2034133667C141105273 @default.
• W2034133667 hasConceptScore W2034133667C159654299 @default.
• W2034133667 hasConceptScore W2034133667C170493617 @default.

• next