FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034133901> ?p ?o ?g. }

• W2034133901 endingPage "359" @default.
• W2034133901 startingPage "349" @default.
• W2034133901 abstract "How the ER-associated degradation (ERAD) machinery accurately identifies terminally misfolded proteins is poorly understood. For luminal ERAD substrates, this recognition depends on their folding and glycosylation status as well as on the conserved ER lectin Yos9p. Here we show that Yos9p is part of a stable complex that organizes key components of ERAD machinery on both sides of the ER membrane, including the transmembrane ubiquitin ligase Hrd1p. We further demonstrate that Yos9p, together with Kar2p and Hrd3p, forms a luminal surveillance complex that both recruits nonnative proteins to the core ERAD machinery and assists a distinct sugar-dependent step necessary to commit substrates for degradation. When Hrd1p is uncoupled from the Yos9p surveillance complex, degradation can occur independently of the requirement for glycosylation. Thus, Yos9p/Kar2p/Hrd3p acts as a gatekeeper, ensuring correct identification of terminally misfolded proteins by recruiting misfolded forms to the ERAD machinery, contributing to the interrogation of substrate sugar status, and preventing glycosylation-independent degradation." @default.
• W2034133901 created "2016-06-24" @default.
• W2034133901 creator A5010255611 @default.
• W2034133901 creator A5015152221 @default.
• W2034133901 creator A5026663934 @default.
• W2034133901 date "2006-07-01" @default.
• W2034133901 modified "2023-10-13" @default.
• W2034133901 title "A Luminal Surveillance Complex that Selects Misfolded Glycoproteins for ER-Associated Degradation" @default.
• W2034133901 cites W1575978940 @default.
• W2034133901 cites W1668688100 @default.
• W2034133901 cites W1965588273 @default.
• W2034133901 cites W1965839025 @default.
• W2034133901 cites W1974004166 @default.
• W2034133901 cites W1980420611 @default.
• W2034133901 cites W1981551685 @default.
• W2034133901 cites W1981625315 @default.
• W2034133901 cites W1984347348 @default.
• W2034133901 cites W1991400488 @default.
• W2034133901 cites W1999746307 @default.
• W2034133901 cites W2000447975 @default.
• W2034133901 cites W2000806214 @default.
• W2034133901 cites W2010862596 @default.
• W2034133901 cites W2015357935 @default.
• W2034133901 cites W2017776769 @default.
• W2034133901 cites W2018467767 @default.
• W2034133901 cites W2019261756 @default.
• W2034133901 cites W2023680254 @default.
• W2034133901 cites W2025226894 @default.
• W2034133901 cites W2028062152 @default.
• W2034133901 cites W2033088972 @default.
• W2034133901 cites W2041674095 @default.
• W2034133901 cites W2047455709 @default.
• W2034133901 cites W2049127225 @default.
• W2034133901 cites W2049656093 @default.
• W2034133901 cites W2051881845 @default.
• W2034133901 cites W2053274242 @default.
• W2034133901 cites W2055402356 @default.
• W2034133901 cites W2064609154 @default.
• W2034133901 cites W2065022563 @default.
• W2034133901 cites W2072534938 @default.
• W2034133901 cites W2074616759 @default.
• W2034133901 cites W2076787121 @default.
• W2034133901 cites W2080423498 @default.
• W2034133901 cites W2083516848 @default.
• W2034133901 cites W2089925321 @default.
• W2034133901 cites W2110685895 @default.
• W2034133901 cites W2115977447 @default.
• W2034133901 cites W2121576917 @default.
• W2034133901 cites W2121689536 @default.
• W2034133901 cites W2125841023 @default.
• W2034133901 cites W2126653182 @default.
• W2034133901 cites W2135513925 @default.
• W2034133901 cites W2137755719 @default.
• W2034133901 cites W2139577310 @default.
• W2034133901 cites W2145174769 @default.
• W2034133901 cites W2146183177 @default.
• W2034133901 cites W2150740284 @default.
• W2034133901 cites W2151608616 @default.
• W2034133901 cites W2165092054 @default.
• W2034133901 cites W2165627141 @default.
• W2034133901 cites W2169221124 @default.
• W2034133901 doi "https://doi.org/10.1016/j.cell.2006.05.045" @default.
• W2034133901 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16873065" @default.
• W2034133901 hasPublicationYear "2006" @default.
• W2034133901 type Work @default.
• W2034133901 sameAs 2034133901 @default.
• W2034133901 citedByCount "389" @default.
• W2034133901 countsByYear W20341339012012 @default.
• W2034133901 countsByYear W20341339012013 @default.
• W2034133901 countsByYear W20341339012014 @default.
• W2034133901 countsByYear W20341339012015 @default.
• W2034133901 countsByYear W20341339012016 @default.
• W2034133901 countsByYear W20341339012017 @default.
• W2034133901 countsByYear W20341339012018 @default.
• W2034133901 countsByYear W20341339012019 @default.
• W2034133901 countsByYear W20341339012020 @default.
• W2034133901 countsByYear W20341339012021 @default.
• W2034133901 countsByYear W20341339012022 @default.
• W2034133901 countsByYear W20341339012023 @default.
• W2034133901 crossrefType "journal-article" @default.
• W2034133901 hasAuthorship W2034133901A5010255611 @default.
• W2034133901 hasAuthorship W2034133901A5015152221 @default.
• W2034133901 hasAuthorship W2034133901A5026663934 @default.
• W2034133901 hasBestOaLocation W20341339011 @default.
• W2034133901 hasConcept C104317684 @default.
• W2034133901 hasConcept C108625454 @default.
• W2034133901 hasConcept C134459356 @default.
• W2034133901 hasConcept C158619295 @default.
• W2034133901 hasConcept C170493617 @default.
• W2034133901 hasConcept C204328495 @default.
• W2034133901 hasConcept C24530287 @default.
• W2034133901 hasConcept C25602115 @default.
• W2034133901 hasConcept C2777313579 @default.
• W2034133901 hasConcept C2992195973 @default.
• W2034133901 hasConcept C55493867 @default.
• W2034133901 hasConcept C86803240 @default.
• W2034133901 hasConcept C95444343 @default.
• W2034133901 hasConceptScore W2034133901C104317684 @default.

• next