Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034134440> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2034134440 endingPage "601" @default.
- W2034134440 startingPage "595" @default.
- W2034134440 abstract "The role of L3T4 + T lymphocytes in early primary infection with the metacestode of T. taeniaeformis was investigated by selective removal of these cells in vivo by parenteral injections with the rat monoclonal antibody (MAb) GK1.5 directed against the L3T4 molecule. Comparisons between treated and non-treated BALB/cByJ mice, normally resistant to infection with T. taeniaeformis, demonstrated that the treated mice had a greater percentage of viable parasites in the livers. Eosinophils were prominent in the region immediately surrounding parasite larvae in control mice, whereas treated mice showed virtually no eosinophil infiltration. Additionally, fewer tissue macrophages were evident near parasite larvae in the treatment group when compared to controls. The more susceptible C3H/HeDub strain mice demonstrated similar responses following treatment with the MAb, including diminished parasite killing and limited inflammatory cell infiltration. When C3H/HeDub mice were injected with the cytotoxic agent vinblastine sulfate, which has been shown to diminish Lyt-2 + suppressor cell activity, these mice remained unable to mount a strong local cellular response to the larval parasite. It is suggested that L3T4 + T lymphocytes play a crucial role in the innate resistance to T. taeniaeformis infection during the first 6 days post-infection. Effects seen following vinblastine treatment may be a result of drug-induced alterations in leukocyte chemotaxis, toxicity to other effector T cell populations, or a specific depletion of a functional Lyt-2 + T cell population that is required in addition to L3T4 + T cells for the expression of resistance to primary infection with T. taeniaeformis." @default.
- W2034134440 created "2016-06-24" @default.
- W2034134440 creator A5037409538 @default.
- W2034134440 creator A5056231558 @default.
- W2034134440 date "1990-08-01" @default.
- W2034134440 modified "2023-09-26" @default.
- W2034134440 title "Effect of depletion of L3T4+ cells on resistance to early primary infection of mice with Taenia taeniaeformis" @default.
- W2034134440 cites W136148729 @default.
- W2034134440 cites W1600662889 @default.
- W2034134440 cites W1942668068 @default.
- W2034134440 cites W1970792513 @default.
- W2034134440 cites W1982150163 @default.
- W2034134440 cites W1986247238 @default.
- W2034134440 cites W1990568245 @default.
- W2034134440 cites W1991142526 @default.
- W2034134440 cites W1998214401 @default.
- W2034134440 cites W2022386013 @default.
- W2034134440 cites W2038520664 @default.
- W2034134440 cites W2041978311 @default.
- W2034134440 cites W2097471806 @default.
- W2034134440 cites W2129910187 @default.
- W2034134440 cites W2319855891 @default.
- W2034134440 cites W2320302893 @default.
- W2034134440 cites W2322294493 @default.
- W2034134440 cites W2327169300 @default.
- W2034134440 cites W629057078 @default.
- W2034134440 doi "https://doi.org/10.1016/0020-7519(90)90116-5" @default.
- W2034134440 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2146233" @default.
- W2034134440 hasPublicationYear "1990" @default.
- W2034134440 type Work @default.
- W2034134440 sameAs 2034134440 @default.
- W2034134440 citedByCount "2" @default.
- W2034134440 countsByYear W20341344402018 @default.
- W2034134440 crossrefType "journal-article" @default.
- W2034134440 hasAuthorship W2034134440A5037409538 @default.
- W2034134440 hasAuthorship W2034134440A5056231558 @default.
- W2034134440 hasConcept C153911025 @default.
- W2034134440 hasConcept C203014093 @default.
- W2034134440 hasConcept C2776042228 @default.
- W2034134440 hasConcept C2776090121 @default.
- W2034134440 hasConcept C2777037409 @default.
- W2034134440 hasConcept C2908647359 @default.
- W2034134440 hasConcept C51785407 @default.
- W2034134440 hasConcept C71924100 @default.
- W2034134440 hasConcept C86803240 @default.
- W2034134440 hasConcept C8891405 @default.
- W2034134440 hasConcept C99454951 @default.
- W2034134440 hasConceptScore W2034134440C153911025 @default.
- W2034134440 hasConceptScore W2034134440C203014093 @default.
- W2034134440 hasConceptScore W2034134440C2776042228 @default.
- W2034134440 hasConceptScore W2034134440C2776090121 @default.
- W2034134440 hasConceptScore W2034134440C2777037409 @default.
- W2034134440 hasConceptScore W2034134440C2908647359 @default.
- W2034134440 hasConceptScore W2034134440C51785407 @default.
- W2034134440 hasConceptScore W2034134440C71924100 @default.
- W2034134440 hasConceptScore W2034134440C86803240 @default.
- W2034134440 hasConceptScore W2034134440C8891405 @default.
- W2034134440 hasConceptScore W2034134440C99454951 @default.
- W2034134440 hasIssue "5" @default.
- W2034134440 hasLocation W20341344401 @default.
- W2034134440 hasLocation W20341344402 @default.
- W2034134440 hasOpenAccess W2034134440 @default.
- W2034134440 hasPrimaryLocation W20341344401 @default.
- W2034134440 hasRelatedWork W151983043 @default.
- W2034134440 hasRelatedWork W1536116869 @default.
- W2034134440 hasRelatedWork W2103427065 @default.
- W2034134440 hasRelatedWork W2140516087 @default.
- W2034134440 hasRelatedWork W2408605056 @default.
- W2034134440 hasRelatedWork W2411456541 @default.
- W2034134440 hasRelatedWork W2415059733 @default.
- W2034134440 hasRelatedWork W2620474830 @default.
- W2034134440 hasRelatedWork W4283574129 @default.
- W2034134440 hasRelatedWork W942649159 @default.
- W2034134440 hasVolume "20" @default.
- W2034134440 isParatext "false" @default.
- W2034134440 isRetracted "false" @default.
- W2034134440 magId "2034134440" @default.
- W2034134440 workType "article" @default.