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- W2034135563 abstract "Cerebrospinal fluid (CSF) concentrations of neurotensin (NT) and corticotropin-releasing hormone (CRF)-like immunoreactive materials (LIM) were measured in 22 infants and children 6 days to 15 years of age. For both neuropeptides there was a marked age-related exponential decline in CSF concentrations. The most prominent decrease in CSF neuropeptide concentrations was seen during the first 24 months of postnatal life. From 1 year and on there was no or only minimal age-associated alteration in CSF neuropeptide concentrations. In this group of children (1–15 years) mean CSF concentrations of NT-LIM and CRF-LIM were 36.8 ± 4.32 and 65.9 ± 4.63 pg/ml, respectively. As CSF neuropeptide concentrations are apparently independent of circulating serum concentrations, they may reflect functional activity of neuropeptide-containing neurons and therefore may be of value in the assessment of the role of peptides in the human central nervous system function and behavior." @default.
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- W2034135563 date "1989-01-01" @default.
- W2034135563 modified "2023-09-26" @default.
- W2034135563 title "Cerebrospinal Fluid Concentrations of Neurotensin and Corticotropin-Releasing Factor in Pediatric Patients" @default.
- W2034135563 doi "https://doi.org/10.1159/000242927" @default.
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