FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034135645> ?p ?o ?g. }

• W2034135645 endingPage "126" @default.
• W2034135645 startingPage "119" @default.
• W2034135645 abstract "In a previous study we reported that a new anthracycline derivative (moflomycin) exhibited a higher antileukemic activity compared to other anthracyclines, such as daunorubicin and doxorubicin. To explain the superior antileukemic effect of moflomycin and to disclose a possible structure-activity relationship, we investigated the three main mechanisms by which anthracyclines are though to exert their antitumor effect: DNA binding, free radical production and topoisomerase II inhibition. The DNA interaction was assessed both by DNA binding and DNA unwinding assays, free radical generation was studied by electron spin resonance, and topoisomerase II interaction by analysis of the stimulation of enzyme-induced DNA breaks. The results showed a higher free radical production and a greater stimulation of topoisomerase II-mediated DNA cleavage by moflomycin than doxorubicin, associated with a lower DNA affinity. The different biochemical characteristics of moflomycin, particularly its interaction with topoisomerase II, are related to the structural modifications performed on the chromophore. These properties, associated with a higher stability of the molecule induced by the presence of an iodine atom on the sugar moiety, are probably responsible for the higher antileukemic activity of this compound." @default.
• W2034135645 created "2016-06-24" @default.
• W2034135645 creator A5017477419 @default.
• W2034135645 creator A5029847938 @default.
• W2034135645 creator A5036927429 @default.
• W2034135645 creator A5053249294 @default.
• W2034135645 creator A5080703743 @default.
• W2034135645 creator A5081770852 @default.
• W2034135645 creator A5083937195 @default.
• W2034135645 date "1996-02-01" @default.
• W2034135645 modified "2023-09-25" @default.
• W2034135645 title "Enhanced topoisomerase II-induced DNA breaks and free radical production by a new anthracycline with potent antileukemic activity" @default.
• W2034135645 cites W1495821285 @default.
• W2034135645 cites W1654460714 @default.
• W2034135645 cites W1972410555 @default.
• W2034135645 cites W2000057293 @default.
• W2034135645 cites W2005408885 @default.
• W2034135645 cites W2013733971 @default.
• W2034135645 cites W2016254453 @default.
• W2034135645 cites W2016521087 @default.
• W2034135645 cites W2028908766 @default.
• W2034135645 cites W2030124874 @default.
• W2034135645 cites W2047893495 @default.
• W2034135645 cites W2069891078 @default.
• W2034135645 cites W2085697477 @default.
• W2034135645 cites W2107170545 @default.
• W2034135645 cites W2135943843 @default.
• W2034135645 doi "https://doi.org/10.1016/0145-2126(95)00155-7" @default.
• W2034135645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8628010" @default.
• W2034135645 hasPublicationYear "1996" @default.
• W2034135645 type Work @default.
• W2034135645 sameAs 2034135645 @default.
• W2034135645 citedByCount "7" @default.
• W2034135645 countsByYear W20341356452012 @default.
• W2034135645 countsByYear W20341356452013 @default.
• W2034135645 crossrefType "journal-article" @default.
• W2034135645 hasAuthorship W2034135645A5017477419 @default.
• W2034135645 hasAuthorship W2034135645A5029847938 @default.
• W2034135645 hasAuthorship W2034135645A5036927429 @default.
• W2034135645 hasAuthorship W2034135645A5053249294 @default.
• W2034135645 hasAuthorship W2034135645A5080703743 @default.
• W2034135645 hasAuthorship W2034135645A5081770852 @default.
• W2034135645 hasAuthorship W2034135645A5083937195 @default.
• W2034135645 hasConcept C121608353 @default.
• W2034135645 hasConcept C12554922 @default.
• W2034135645 hasConcept C143425029 @default.
• W2034135645 hasConcept C147897179 @default.
• W2034135645 hasConcept C181199279 @default.
• W2034135645 hasConcept C185592680 @default.
• W2034135645 hasConcept C203014093 @default.
• W2034135645 hasConcept C2776568683 @default.
• W2034135645 hasConcept C2776694085 @default.
• W2034135645 hasConcept C2776802502 @default.
• W2034135645 hasConcept C2778461978 @default.
• W2034135645 hasConcept C2781021840 @default.
• W2034135645 hasConcept C2781303535 @default.
• W2034135645 hasConcept C530470458 @default.
• W2034135645 hasConcept C54355233 @default.
• W2034135645 hasConcept C552990157 @default.
• W2034135645 hasConcept C55493867 @default.
• W2034135645 hasConcept C71240020 @default.
• W2034135645 hasConcept C86803240 @default.
• W2034135645 hasConceptScore W2034135645C121608353 @default.
• W2034135645 hasConceptScore W2034135645C12554922 @default.
• W2034135645 hasConceptScore W2034135645C143425029 @default.
• W2034135645 hasConceptScore W2034135645C147897179 @default.
• W2034135645 hasConceptScore W2034135645C181199279 @default.
• W2034135645 hasConceptScore W2034135645C185592680 @default.
• W2034135645 hasConceptScore W2034135645C203014093 @default.
• W2034135645 hasConceptScore W2034135645C2776568683 @default.
• W2034135645 hasConceptScore W2034135645C2776694085 @default.
• W2034135645 hasConceptScore W2034135645C2776802502 @default.
• W2034135645 hasConceptScore W2034135645C2778461978 @default.
• W2034135645 hasConceptScore W2034135645C2781021840 @default.
• W2034135645 hasConceptScore W2034135645C2781303535 @default.
• W2034135645 hasConceptScore W2034135645C530470458 @default.
• W2034135645 hasConceptScore W2034135645C54355233 @default.
• W2034135645 hasConceptScore W2034135645C552990157 @default.
• W2034135645 hasConceptScore W2034135645C55493867 @default.
• W2034135645 hasConceptScore W2034135645C71240020 @default.
• W2034135645 hasConceptScore W2034135645C86803240 @default.
• W2034135645 hasIssue "2" @default.
• W2034135645 hasLocation W20341356451 @default.
• W2034135645 hasLocation W20341356452 @default.
• W2034135645 hasOpenAccess W2034135645 @default.
• W2034135645 hasPrimaryLocation W20341356451 @default.
• W2034135645 hasRelatedWork W1982526582 @default.
• W2034135645 hasRelatedWork W1988862874 @default.
• W2034135645 hasRelatedWork W1998379566 @default.
• W2034135645 hasRelatedWork W2023035854 @default.
• W2034135645 hasRelatedWork W2030135253 @default.
• W2034135645 hasRelatedWork W2084741969 @default.
• W2034135645 hasRelatedWork W2085697477 @default.
• W2034135645 hasRelatedWork W2150283119 @default.
• W2034135645 hasRelatedWork W3142197916 @default.
• W2034135645 hasRelatedWork W3184042829 @default.
• W2034135645 hasVolume "20" @default.
• W2034135645 isParatext "false" @default.

• next