Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034135997> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2034135997 endingPage "79" @default.
- W2034135997 startingPage "71" @default.
- W2034135997 abstract "Estimation of a content of secondary structures from amino acid composition of IL-2 (TCGF), PDGF and transforming protein p28sis of simian sarcoma virus by means of the previously suggested nomograms (V. P. Zav'yalov and A. I. Denesyuk (1982) Immunol. Lett. 4, 7–14) allowed us to conclude that a dominant secondary structure of these proteins should be α-helix. Its content in PDGF and p28sis was estimated to be ≈50%, and that in IL-2 to be 50–65%. The content of β-pleated structure in PDGF and p28sis does not exceed 10%, and that in IL-2 is found to be 20–30%. In all the proteins investigated five α-helical segments can be distinguished, of which one of the surfaces contains clusters of bulky hydrophobic side chains. As the number of α-helical segments satisfying the principles of packing into a hydrophobic core as well as the overall length of a polypeptide chain of IL-2 and PDGF coincided with those for IFNs, it was decided to arrange α-helices of these proteins into a globular structure by analogy with IFNs (V. P. Zav'yalov and A. I. Denesyuk (1984) Doklady Akad Nauk S.S.S.R. 275, 242–246). In consequence, identical side chains of amino acid residues were found at 9 out of 29 positions in hydrophobic cores of IFN-β and IL-2, p28sis (PDGF), respectively. Thus the homology of hydrophobic cores of the proteins compared is >30%. Probability of chance coincidences of amino acid residues in the hydrophobic cores of p28sis (PDGF) and IFN-β is found to be 0.03, and that deduced from comparison of IL-2 and IFN-β is 0.05. It was concluded that IL-2, PDGF and p28sis must have a three-dimensional structure generally similar to that of IFNs." @default.
- W2034135997 created "2016-06-24" @default.
- W2034135997 creator A5005937757 @default.
- W2034135997 creator A5011717362 @default.
- W2034135997 date "1985-01-01" @default.
- W2034135997 modified "2023-10-16" @default.
- W2034135997 title "Predicted secondary structure and hydrophobic cores of T-cell (TCGF or IL-2) and platelet-derived growth factors as well as of transforming protein p28sis of simian sarcoma virus are similar to those of interferons" @default.
- W2034135997 cites W1498982804 @default.
- W2034135997 cites W1964684476 @default.
- W2034135997 cites W1965359630 @default.
- W2034135997 cites W1965932897 @default.
- W2034135997 cites W2025529909 @default.
- W2034135997 cites W2027857695 @default.
- W2034135997 cites W2051636382 @default.
- W2034135997 cites W2065397406 @default.
- W2034135997 cites W2076809036 @default.
- W2034135997 cites W2093058557 @default.
- W2034135997 doi "https://doi.org/10.1016/0165-2478(85)90178-6" @default.
- W2034135997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2993160" @default.
- W2034135997 hasPublicationYear "1985" @default.
- W2034135997 type Work @default.
- W2034135997 sameAs 2034135997 @default.
- W2034135997 citedByCount "9" @default.
- W2034135997 crossrefType "journal-article" @default.
- W2034135997 hasAuthorship W2034135997A5005937757 @default.
- W2034135997 hasAuthorship W2034135997A5011717362 @default.
- W2034135997 hasConcept C104317684 @default.
- W2034135997 hasConcept C105168689 @default.
- W2034135997 hasConcept C12554922 @default.
- W2034135997 hasConcept C167625842 @default.
- W2034135997 hasConcept C170493617 @default.
- W2034135997 hasConcept C180361614 @default.
- W2034135997 hasConcept C185592680 @default.
- W2034135997 hasConcept C2775960820 @default.
- W2034135997 hasConcept C515207424 @default.
- W2034135997 hasConcept C55493867 @default.
- W2034135997 hasConcept C62614982 @default.
- W2034135997 hasConcept C8010536 @default.
- W2034135997 hasConcept C86803240 @default.
- W2034135997 hasConcept C90260826 @default.
- W2034135997 hasConceptScore W2034135997C104317684 @default.
- W2034135997 hasConceptScore W2034135997C105168689 @default.
- W2034135997 hasConceptScore W2034135997C12554922 @default.
- W2034135997 hasConceptScore W2034135997C167625842 @default.
- W2034135997 hasConceptScore W2034135997C170493617 @default.
- W2034135997 hasConceptScore W2034135997C180361614 @default.
- W2034135997 hasConceptScore W2034135997C185592680 @default.
- W2034135997 hasConceptScore W2034135997C2775960820 @default.
- W2034135997 hasConceptScore W2034135997C515207424 @default.
- W2034135997 hasConceptScore W2034135997C55493867 @default.
- W2034135997 hasConceptScore W2034135997C62614982 @default.
- W2034135997 hasConceptScore W2034135997C8010536 @default.
- W2034135997 hasConceptScore W2034135997C86803240 @default.
- W2034135997 hasConceptScore W2034135997C90260826 @default.
- W2034135997 hasIssue "2" @default.
- W2034135997 hasLocation W20341359971 @default.
- W2034135997 hasLocation W20341359972 @default.
- W2034135997 hasOpenAccess W2034135997 @default.
- W2034135997 hasPrimaryLocation W20341359971 @default.
- W2034135997 hasRelatedWork W1526474308 @default.
- W2034135997 hasRelatedWork W1655390283 @default.
- W2034135997 hasRelatedWork W1971896762 @default.
- W2034135997 hasRelatedWork W2043649713 @default.
- W2034135997 hasRelatedWork W2070538015 @default.
- W2034135997 hasRelatedWork W2073375101 @default.
- W2034135997 hasRelatedWork W2079750084 @default.
- W2034135997 hasRelatedWork W2171305187 @default.
- W2034135997 hasRelatedWork W2414392548 @default.
- W2034135997 hasRelatedWork W2094510837 @default.
- W2034135997 hasVolume "10" @default.
- W2034135997 isParatext "false" @default.
- W2034135997 isRetracted "false" @default.
- W2034135997 magId "2034135997" @default.
- W2034135997 workType "article" @default.