Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034136246> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W2034136246 abstract "The autoimmune thyroid diseases (AITDs) are multifactorial diseases which result from interplays between predisposing genes and triggering environmental factors. In order to study the genetic susceptibility factors to AITDs, we have followed up 115 control members belonging to a large Tunisian family with a high prevalence of AITDs (Akr family) during 15 years between 1990 to 2005. The follow-up of these control members have showed that 13 subjects (11.3%) developed AITDs (G2). The Hashimoto thyroiditis was the most frequently seen in 77% of the cases, whereas the Graves's disease was present in 23% of the cases. One hundred and two members remained controls (G1). High female predominance was noted in the two groups. The mean age of the G1 subjects group was slightly higher than that of G2. The prevalence of positive antithyroglobulin antibody (TgAb) and antithyroperoxydase antibody (TPOAb) was more frequent in G2 group (P=0.27 and P=0.23) respectively. The HLA haplotypes was realized in 42% of control members. The most frequent HLA haplotypes that were found were B37, DRB11 and A1. HLA B37 and DRB11 were significantly more frequent for the patients of G2 (P=0.0001 and P=0.034) respectively. Our study confirms the contribution of the genetic factors in the development of AITDs in 'Akr' family and suggested that the members of this family share the same genetic inheritance." @default.
- W2034136246 created "2016-06-24" @default.
- W2034136246 creator A5021767427 @default.
- W2034136246 creator A5026591097 @default.
- W2034136246 creator A5040408448 @default.
- W2034136246 creator A5060142854 @default.
- W2034136246 creator A5061468431 @default.
- W2034136246 creator A5064968834 @default.
- W2034136246 creator A5080504428 @default.
- W2034136246 date "2009-07-01" @default.
- W2034136246 modified "2023-09-26" @default.
- W2034136246 title "Prédisposition aux maladies auto-immunes thyroïdiennes au sein d’une famille tunisienne multiplexe" @default.
- W2034136246 cites W15941765 @default.
- W2034136246 cites W1976057202 @default.
- W2034136246 cites W1977144711 @default.
- W2034136246 cites W1983212073 @default.
- W2034136246 cites W1988129408 @default.
- W2034136246 cites W1991300758 @default.
- W2034136246 cites W2013304880 @default.
- W2034136246 cites W2033248235 @default.
- W2034136246 cites W2047005985 @default.
- W2034136246 cites W2054664456 @default.
- W2034136246 cites W2058267475 @default.
- W2034136246 cites W2061554472 @default.
- W2034136246 cites W2069339982 @default.
- W2034136246 cites W2075954165 @default.
- W2034136246 cites W2081789882 @default.
- W2034136246 cites W2083578183 @default.
- W2034136246 cites W2097597413 @default.
- W2034136246 cites W2102872217 @default.
- W2034136246 cites W2114998847 @default.
- W2034136246 cites W2133547068 @default.
- W2034136246 cites W2140195025 @default.
- W2034136246 cites W2140936682 @default.
- W2034136246 cites W2410530805 @default.
- W2034136246 cites W2417180050 @default.
- W2034136246 cites W2472017718 @default.
- W2034136246 doi "https://doi.org/10.1016/j.patbio.2007.09.004" @default.
- W2034136246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18226469" @default.
- W2034136246 hasPublicationYear "2009" @default.
- W2034136246 type Work @default.
- W2034136246 sameAs 2034136246 @default.
- W2034136246 citedByCount "2" @default.
- W2034136246 countsByYear W20341362462012 @default.
- W2034136246 crossrefType "journal-article" @default.
- W2034136246 hasAuthorship W2034136246A5021767427 @default.
- W2034136246 hasAuthorship W2034136246A5026591097 @default.
- W2034136246 hasAuthorship W2034136246A5040408448 @default.
- W2034136246 hasAuthorship W2034136246A5060142854 @default.
- W2034136246 hasAuthorship W2034136246A5061468431 @default.
- W2034136246 hasAuthorship W2034136246A5064968834 @default.
- W2034136246 hasAuthorship W2034136246A5080504428 @default.
- W2034136246 hasConcept C29456083 @default.
- W2034136246 hasConcept C71924100 @default.
- W2034136246 hasConceptScore W2034136246C29456083 @default.
- W2034136246 hasConceptScore W2034136246C71924100 @default.
- W2034136246 hasLocation W20341362461 @default.
- W2034136246 hasLocation W20341362462 @default.
- W2034136246 hasOpenAccess W2034136246 @default.
- W2034136246 hasPrimaryLocation W20341362461 @default.
- W2034136246 isParatext "false" @default.
- W2034136246 isRetracted "false" @default.
- W2034136246 magId "2034136246" @default.
- W2034136246 workType "article" @default.