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• W2034137510 abstract "Sixteen children with idiopathic hypercalciuria and seven control children were observed. Patients were classified into two groups by means of an orally administered calcium loading test. Individuals with renal hypercalciuria (five children) had a high fasting urinary calcium/creatinine concentration ratio (0.27±0.05), a mild increase of this value after calcium administration (0.29±0.07, P<0.05), and elevated mean serum parathyroid hormone (PTH) concentrations (0.95±1.14 ng/ml). Patients with absorptive hypercalciura (11 children) had fasting urinary calcium/creatinine concentration ratio of 0.11±0.04, a large increase of this index after calcium loading (0.25±0.06, P<0.0005), and normal levels of serum PTH (0.29±0.10 ng/ml). Next, we examined the effects of two different calcium intakes on urinary calcium excretion, serum calcium, PTH, and 1,25-dihydroxyvitamin D3 concentrations. In patients with absorptive hypercalciuria, the increased calcium intake resulted in significant increments of calciuria (P<0.0005), mild elevation of serum calcium concentration (P<0.05), and reduction of serum 1,25-dihydroxyvitamin D3 concentrations (P<0.005). By contrast, these values were not modified in children with renal hypercalciuria. Serum PTH did not change within each group. After dietary calcium supplementation, serum ratios of 1,25-dihydroxyvitamin D3 to calcium, phosphate, and PTH concentrations deceeased significantly only in the group of children with absorptive hypercalciuria. Our data support the contention that 1,25-dihydroxyvitamin D3 metabolism is different in the two groups of patients with hypercalciuria. Sixteen children with idiopathic hypercalciuria and seven control children were observed. Patients were classified into two groups by means of an orally administered calcium loading test. Individuals with renal hypercalciuria (five children) had a high fasting urinary calcium/creatinine concentration ratio (0.27±0.05), a mild increase of this value after calcium administration (0.29±0.07, P<0.05), and elevated mean serum parathyroid hormone (PTH) concentrations (0.95±1.14 ng/ml). Patients with absorptive hypercalciura (11 children) had fasting urinary calcium/creatinine concentration ratio of 0.11±0.04, a large increase of this index after calcium loading (0.25±0.06, P<0.0005), and normal levels of serum PTH (0.29±0.10 ng/ml). Next, we examined the effects of two different calcium intakes on urinary calcium excretion, serum calcium, PTH, and 1,25-dihydroxyvitamin D3 concentrations. In patients with absorptive hypercalciuria, the increased calcium intake resulted in significant increments of calciuria (P<0.0005), mild elevation of serum calcium concentration (P<0.05), and reduction of serum 1,25-dihydroxyvitamin D3 concentrations (P<0.005). By contrast, these values were not modified in children with renal hypercalciuria. Serum PTH did not change within each group. After dietary calcium supplementation, serum ratios of 1,25-dihydroxyvitamin D3 to calcium, phosphate, and PTH concentrations deceeased significantly only in the group of children with absorptive hypercalciuria. Our data support the contention that 1,25-dihydroxyvitamin D3 metabolism is different in the two groups of patients with hypercalciuria." @default.
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• W2034137510 date "1987-02-01" @default.
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• W2034137510 title "Idiopathic hypercalciuria in children: Pathophysiologic considerations of renal and absorptive subtypes" @default.
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• W2034137510 doi "https://doi.org/10.1016/s0022-3476(87)80161-0" @default.
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