FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034137976> ?p ?o ?g. }

• W2034137976 endingPage "761" @default.
• W2034137976 startingPage "754" @default.
• W2034137976 abstract "Coptis chinensis rhizomes (Coptidis Rhizoma, CR), also known as Huang Lian, is a common component of traditional Chinese herbal formulae used for the relief of abdominal pain and diarrhea. Yet, the action mechanism of CR extract in the treatment of irritable bowel syndrome is unknown. Thus, the aim of our present study is to investigate the effect of CR extract on neonatal maternal separation (NMS)-induced visceral hyperalgesia in rats and its underlying action mechanisms.Male Sprague-Dawley rats were subjected to 3-h daily maternal separation from postnatal day 2 to day 21 to form the NMS group. The control group consists of unseparated normal (N) rats. From day 60, rats were administrated CR (0.3, 0.8 and 1.3 g/kg) or vehicle (Veh; 0.5% carboxymethylcellulose solution) orally for 7 days for the test and control groups, respectively.Electromyogram (EMG) signals in response to colonic distension were measured with the NMS rats showing lower pain threshold and increased EMG activity than those of the unseparated (N) rats. CR dose-dependently increased pain threshold response and attenuated EMG activity in the NMS rats. An enzymatic immunoassay study showed that CR treatment significantly reduced the serotonin (5HT) concentration from the distal colon of NMS rats compared to the Veh (control) group. Real-time quantitative PCR and Western-blotting studies showed that CR treatment substantially reduced NMS induced cholecystokinin (CCK) expression compared with the Veh group.These results suggest that CR extract robustly reduces visceral pain that may be mediated via the mechanism of decreasing 5HT release and CCK expression in the distal colon of rats." @default.
• W2034137976 created "2016-06-24" @default.
• W2034137976 creator A5005117088 @default.
• W2034137976 creator A5012856135 @default.
• W2034137976 creator A5013223582 @default.
• W2034137976 creator A5015198590 @default.
• W2034137976 creator A5049274840 @default.
• W2034137976 creator A5049567539 @default.
• W2034137976 creator A5083448314 @default.
• W2034137976 date "2011-06-01" @default.
• W2034137976 modified "2023-10-06" @default.
• W2034137976 title "Analgesic effect of Coptis chinensis rhizomes (Coptidis Rhizoma) extract on rat model of irritable bowel syndrome" @default.
• W2034137976 cites W1522035126 @default.
• W2034137976 cites W1648481394 @default.
• W2034137976 cites W1964730884 @default.
• W2034137976 cites W1966160259 @default.
• W2034137976 cites W1977790735 @default.
• W2034137976 cites W1978146309 @default.
• W2034137976 cites W1984181078 @default.
• W2034137976 cites W1985243765 @default.
• W2034137976 cites W1994072964 @default.
• W2034137976 cites W1998400098 @default.
• W2034137976 cites W2000409992 @default.
• W2034137976 cites W2000587317 @default.
• W2034137976 cites W2001416500 @default.
• W2034137976 cites W2002694496 @default.
• W2034137976 cites W2002818394 @default.
• W2034137976 cites W2006344901 @default.
• W2034137976 cites W2007666404 @default.
• W2034137976 cites W2014163936 @default.
• W2034137976 cites W2014814979 @default.
• W2034137976 cites W2035555128 @default.
• W2034137976 cites W2045862390 @default.
• W2034137976 cites W2046900237 @default.
• W2034137976 cites W2047238185 @default.
• W2034137976 cites W2055206463 @default.
• W2034137976 cites W2056877663 @default.
• W2034137976 cites W2058976148 @default.
• W2034137976 cites W2061218746 @default.
• W2034137976 cites W2063931940 @default.
• W2034137976 cites W2065300532 @default.
• W2034137976 cites W2067042083 @default.
• W2034137976 cites W2067105764 @default.
• W2034137976 cites W2069749037 @default.
• W2034137976 cites W2071956277 @default.
• W2034137976 cites W2073471715 @default.
• W2034137976 cites W2074969495 @default.
• W2034137976 cites W2110726089 @default.
• W2034137976 cites W2111058831 @default.
• W2034137976 cites W2114570899 @default.
• W2034137976 cites W2126452889 @default.
• W2034137976 cites W2127292115 @default.
• W2034137976 cites W2139006666 @default.
• W2034137976 cites W2140907934 @default.
• W2034137976 cites W2144967252 @default.
• W2034137976 cites W2168259047 @default.
• W2034137976 cites W2405028393 @default.
• W2034137976 cites W94291018 @default.
• W2034137976 doi "https://doi.org/10.1016/j.jep.2011.04.007" @default.
• W2034137976 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3100428" @default.
• W2034137976 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21511022" @default.
• W2034137976 hasPublicationYear "2011" @default.
• W2034137976 type Work @default.
• W2034137976 sameAs 2034137976 @default.
• W2034137976 citedByCount "52" @default.
• W2034137976 countsByYear W20341379762012 @default.
• W2034137976 countsByYear W20341379762013 @default.
• W2034137976 countsByYear W20341379762014 @default.
• W2034137976 countsByYear W20341379762015 @default.
• W2034137976 countsByYear W20341379762016 @default.
• W2034137976 countsByYear W20341379762017 @default.
• W2034137976 countsByYear W20341379762018 @default.
• W2034137976 countsByYear W20341379762019 @default.
• W2034137976 countsByYear W20341379762020 @default.
• W2034137976 countsByYear W20341379762022 @default.
• W2034137976 countsByYear W20341379762023 @default.
• W2034137976 crossrefType "journal-article" @default.
• W2034137976 hasAuthorship W2034137976A5005117088 @default.
• W2034137976 hasAuthorship W2034137976A5012856135 @default.
• W2034137976 hasAuthorship W2034137976A5013223582 @default.
• W2034137976 hasAuthorship W2034137976A5015198590 @default.
• W2034137976 hasAuthorship W2034137976A5049274840 @default.
• W2034137976 hasAuthorship W2034137976A5049567539 @default.
• W2034137976 hasAuthorship W2034137976A5083448314 @default.
• W2034137976 hasBestOaLocation W20341379762 @default.
• W2034137976 hasConcept C102652120 @default.
• W2034137976 hasConcept C126322002 @default.
• W2034137976 hasConcept C134550120 @default.
• W2034137976 hasConcept C142724271 @default.
• W2034137976 hasConcept C15490471 @default.
• W2034137976 hasConcept C170493617 @default.
• W2034137976 hasConcept C188947578 @default.
• W2034137976 hasConcept C204787440 @default.
• W2034137976 hasConcept C2775913212 @default.
• W2034137976 hasConcept C2776625112 @default.
• W2034137976 hasConcept C2777073116 @default.
• W2034137976 hasConcept C2777397596 @default.
• W2034137976 hasConcept C2778271842 @default.

• next