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- W2034138545 abstract "WE have previously shown that block of high-frequency stimulation (HFS) induced long-term potentiation (LTP) of synaptic transmission in area CA1 by (1S,3S)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3S-ACPD; 5 μl of a 20 mM solution), an agonist at group II metabotropic glutamate receptors, did not prevent animals from learning a spatial task. Here we show that the same dose of 1S,3S-ACPD also blocked the induction of HFS-induced LTP of the slope of the excitatory post-synaptic potential and of the amplitude of the population spike in the dentate gyrus. We conclude that HFS-induced LTP in the dentate gyrus is not a good model for memory formation." @default.
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- W2034138545 date "1997-01-01" @default.
- W2034138545 modified "2023-10-18" @default.
- W2034138545 title "Block of HFS-induced LTP in the dentate gyrus by 1S,3S-ACPD" @default.
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- W2034138545 doi "https://doi.org/10.1097/00001756-199701200-00015" @default.
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