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- W2034139274 abstract "By use of the push-pull perfusion technique, release of neuronal cholecystokinin-like immunoreactivity (CCK-LI) from hypothalamus of owl monkeys was investigated in relation to an intragastric meal. In overnight fasted, halothane-anesthetized owl monkeys, levels of CCK-LI in the hypothalamic push-pull perfusate were below assay sensitivity (<4pg/30min). After intragastric administration of a carbohydrate/amino acid meal, however, a 10-fold increase in CCK-LI release (51 ± 7pg/30min) was observed in 5 out of 15 perfusion sites during the first postprandial 30 min. During the subsequent two 30-min intervals, release of CCK-LI was still increased with 32 ± 5pg/30min and 15 ± 6pg/30min, respectively. Thereafter, CCK-LI release was below assay sensitivity again. Addition of 40 mM potassium chloride (KCl) to the perfusion solution, which causes neuronal depolarization, resulted in a second increase in CCK-LI release of 56 ± 7pg/30min which was comparable to the meal-induced release. All sites that exhibited an increase in CCK-LI were located in the anterolateral aspect of the hypothalamus. In experiments without meal-induced release, KCl did not have any effect on CCK-LI in perfusate, suggesting that these particular sites did not contain CCK-releasing terminals. High performance liquid chromatography (HPLC) identified the C-terminal octapeptide of CCK (CCK-8) as the predominant molecular form of CCK within the owl monkey hypothalamus. No gastrin-17 was present. This study extends previously reported findings in cats to a primate species that (1) neurons which release CCK in hypothalamus are activated by stimuli generated by a gastric meal load, and (2) further supports the hypothesis that neuronal CCK within the hypothalamus may play a physiological role which correlates with the termination of feeding." @default.
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- W2034139274 date "1987-08-01" @default.
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- W2034139274 title "Neuronal cholecystokinin-like immunoreactivity is postprandially released from primate hypothalamus" @default.
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- W2034139274 doi "https://doi.org/10.1016/0006-8993(87)90957-7" @default.
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