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- W2034139519 abstract "Technological advances in both siRNA (small interfering RNA) and whole genome sequencing have demonstrated great potential in translating genetic information into siRNA-based drugs to halt the synthesis of most disease-causing proteins. Despite its powerful promises as a drug, siRNA requires a sophisticated delivery vehicle because of its rapid degradation in the circulation, inefficient accumulation in target tissues and inability to cross cell membranes to access the cytoplasm where it functions. Lipid nanoparticle (LNP) containing ionizable amino lipids is the leading delivery technology for siRNA, with five products in clinical trials and more in the pipeline. Here, we focus on the technological advances behind these potent systems for siRNA-mediated gene silencing." @default.
- W2034139519 created "2016-06-24" @default.
- W2034139519 creator A5000937284 @default.
- W2034139519 creator A5049380011 @default.
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- W2034139519 date "2013-09-18" @default.
- W2034139519 modified "2023-10-14" @default.
- W2034139519 title "Advances in Lipid Nanoparticles for siRNA Delivery" @default.
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- W2034139519 doi "https://doi.org/10.3390/pharmaceutics5030498" @default.
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