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- W2034139567 abstract "Many pharmaceutical companies are now exploring combination drug therapies as an alternative to monotherapy. Consequently, it is of interest to investigate the simultaneous dose response relationship of two active drugs to select the lowest effective combination. In this paper, we propose a method for designing clinical trials for drug combinations that seems to offer several advantages over the 4 x 3 or even larger factorial studies that have been used to date. In addition, our proposed method provides a convenient formula for calculating the required sample size." @default.
- W2034139567 created "2016-06-24" @default.
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- W2034139567 date "1992-01-01" @default.
- W2034139567 modified "2023-09-26" @default.
- W2034139567 title "A method of designing clinical trials for combination drugs" @default.
- W2034139567 cites W4251240133 @default.
- W2034139567 cites W75897680 @default.
- W2034139567 doi "https://doi.org/10.1002/sim.4780110808" @default.
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