FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034141900> ?p ?o ?g. }

• W2034141900 endingPage "144" @default.
• W2034141900 startingPage "133" @default.
• W2034141900 abstract "2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental toxin formed as an unintentional by-product of incomplete combustion. Several therapeutic approaches have evolved to combat its toxicity since it elicits immunotoxicity, neurotoxicity, hepatotoxicity, carcinogenicity and lethality. Search for drugs from natural resources especially from seaweeds has become intense due to their enormous pharmacological potential. Hence, the present study aims at revealing the protective effect of methanolic extract of G. acerosa (MEGA) in Peripheral Blood Mononuclear Cells (PBMC) against TCDD induced toxicity, by assessing the antioxidant, anti-apoptotic and cytoprotective activities. The results of antioxidant assays suggests that MEGA reverted TCDD induced toxicity by causing an alteration in the levels of antioxidant enzymes (Catalase [CAT], Superoxide dismutase [SOD], Glutathione peroxidase [GPx], Glutathione-S-transferase [GST]) and Glutathione [GSH]. The results of lipid peroxidation assay and protein carbonyl content reveal that MEGA protects PBMC from TCDD induced macromolecular damage. MEGA was found to exhibit significant (p < 0.05) anti-apoptotic activity as verified by evaluation of mitochondrial membrane potential and AO-EtBr dual staining. In addition, PBMC co-treated with MEGA prevented TCDD induced oxidative DNA damage. Levels of phase-I detoxification enzymes determined by EROD assay and semi-quantitative RT-PCR showed that TCDD up-regulates the expression of CYP1A1 and upon co-treatment with MEGA, the expression got slightly decreased suggesting its protective role. Preliminary phytochemical analysis demonstrates that the extract is rich in cardiac glycosides and terpenoids. LC-MS analysis revealed the presence of antioxidants including caffeic acid, phytol and mannoheptulose in MEGA, which could be attributed for the observed protective effect against TCDD induced toxicity." @default.
• W2034141900 created "2016-06-24" @default.
• W2034141900 creator A5016632550 @default.
• W2034141900 creator A5026971098 @default.
• W2034141900 creator A5040095384 @default.
• W2034141900 creator A5044127242 @default.
• W2034141900 creator A5078994905 @default.
• W2034141900 date "2014-05-21" @default.
• W2034141900 modified "2023-10-14" @default.
• W2034141900 title "Antioxidant compounds in the seaweed<i>Gelidiella acerosa</i>protects human Peripheral Blood Mononuclear Cells against TCDD induced toxicity" @default.
• W2034141900 cites W1519940258 @default.
• W2034141900 cites W1567614586 @default.
• W2034141900 cites W1581414347 @default.
• W2034141900 cites W1590512020 @default.
• W2034141900 cites W1595242735 @default.
• W2034141900 cites W1775749144 @default.
• W2034141900 cites W191793640 @default.
• W2034141900 cites W1964353013 @default.
• W2034141900 cites W1965838747 @default.
• W2034141900 cites W1970473804 @default.
• W2034141900 cites W1976277533 @default.
• W2034141900 cites W1982877771 @default.
• W2034141900 cites W1983310681 @default.
• W2034141900 cites W1983598782 @default.
• W2034141900 cites W1986286660 @default.
• W2034141900 cites W1986928947 @default.
• W2034141900 cites W1986931603 @default.
• W2034141900 cites W1991250985 @default.
• W2034141900 cites W1996555750 @default.
• W2034141900 cites W1997170151 @default.
• W2034141900 cites W2023536393 @default.
• W2034141900 cites W2032574998 @default.
• W2034141900 cites W2041839476 @default.
• W2034141900 cites W2050145642 @default.
• W2034141900 cites W2051082311 @default.
• W2034141900 cites W2061816270 @default.
• W2034141900 cites W2063576996 @default.
• W2034141900 cites W2064195385 @default.
• W2034141900 cites W2066678654 @default.
• W2034141900 cites W2078042539 @default.
• W2034141900 cites W2078054541 @default.
• W2034141900 cites W2078963270 @default.
• W2034141900 cites W2080994828 @default.
• W2034141900 cites W2082583976 @default.
• W2034141900 cites W2086881941 @default.
• W2034141900 cites W2092629964 @default.
• W2034141900 cites W2127224314 @default.
• W2034141900 cites W2130538892 @default.
• W2034141900 cites W2136175619 @default.
• W2034141900 cites W2162067613 @default.
• W2034141900 cites W2163531002 @default.
• W2034141900 cites W2169637929 @default.
• W2034141900 cites W2253848447 @default.
• W2034141900 cites W4256249844 @default.
• W2034141900 doi "https://doi.org/10.3109/01480545.2014.919582" @default.
• W2034141900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24844840" @default.
• W2034141900 hasPublicationYear "2014" @default.
• W2034141900 type Work @default.
• W2034141900 sameAs 2034141900 @default.
• W2034141900 citedByCount "4" @default.
• W2034141900 countsByYear W20341419002017 @default.
• W2034141900 countsByYear W20341419002019 @default.
• W2034141900 countsByYear W20341419002021 @default.
• W2034141900 crossrefType "journal-article" @default.
• W2034141900 hasAuthorship W2034141900A5016632550 @default.
• W2034141900 hasAuthorship W2034141900A5026971098 @default.
• W2034141900 hasAuthorship W2034141900A5040095384 @default.
• W2034141900 hasAuthorship W2034141900A5044127242 @default.
• W2034141900 hasAuthorship W2034141900A5078994905 @default.
• W2034141900 hasConcept C137061746 @default.
• W2034141900 hasConcept C165069038 @default.
• W2034141900 hasConcept C178790620 @default.
• W2034141900 hasConcept C181199279 @default.
• W2034141900 hasConcept C185592680 @default.
• W2034141900 hasConcept C202751555 @default.
• W2034141900 hasConcept C2775838275 @default.
• W2034141900 hasConcept C2776151105 @default.
• W2034141900 hasConcept C2778004101 @default.
• W2034141900 hasConcept C2778760513 @default.
• W2034141900 hasConcept C2778979269 @default.
• W2034141900 hasConcept C2779491297 @default.
• W2034141900 hasConcept C2780829032 @default.
• W2034141900 hasConcept C29730261 @default.
• W2034141900 hasConcept C538909803 @default.
• W2034141900 hasConcept C55493867 @default.
• W2034141900 hasConcept C86803240 @default.
• W2034141900 hasConcept C98274493 @default.
• W2034141900 hasConceptScore W2034141900C137061746 @default.
• W2034141900 hasConceptScore W2034141900C165069038 @default.
• W2034141900 hasConceptScore W2034141900C178790620 @default.
• W2034141900 hasConceptScore W2034141900C181199279 @default.
• W2034141900 hasConceptScore W2034141900C185592680 @default.
• W2034141900 hasConceptScore W2034141900C202751555 @default.
• W2034141900 hasConceptScore W2034141900C2775838275 @default.
• W2034141900 hasConceptScore W2034141900C2776151105 @default.
• W2034141900 hasConceptScore W2034141900C2778004101 @default.
• W2034141900 hasConceptScore W2034141900C2778760513 @default.
• W2034141900 hasConceptScore W2034141900C2778979269 @default.

• next