FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034142713> ?p ?o ?g. }

• W2034142713 endingPage "10579" @default.
• W2034142713 startingPage "10571" @default.
• W2034142713 abstract "Some fibroblast growth factors (FGFs) play a critical role in tumorigenesis and progression. Among them, FGF2 was highly expressed in some tumors, and antagonists binding to FGF2 can suppress the growth of tumor cells. Therefore, FGF2 has been considered as an important target in cancer therapy. In this study, we identified a novel FGF2-binding short peptide (P8, PLLQATAGGGS-NH2) using phage display technology and alanine scanning. The P8 peptide suppressed FGF2-induced proliferation with no cytotoxic effect on cells, arrested the cycle at the G0/G1 phase in B16-F10 cells, and downregulated the activation of fibroblast growth factor receptor substrate 2α (FRS2α)/ERK cascade in B16-F10, NIH-H460, and SGC-7901 cells. Besides, P8 peptide can also inhibit the phosphorylation of FRS2α stimulated by FGF1 and KGF2. These implied that P8 peptide may develop as a multi-target antagonist peptide contributing to tumor treatment." @default.
• W2034142713 created "2016-06-24" @default.
• W2034142713 creator A5010566551 @default.
• W2034142713 creator A5011740024 @default.
• W2034142713 creator A5014656305 @default.
• W2034142713 creator A5017441654 @default.
• W2034142713 creator A5033845983 @default.
• W2034142713 creator A5038617111 @default.
• W2034142713 creator A5046078938 @default.
• W2034142713 creator A5062336405 @default.
• W2034142713 creator A5074286511 @default.
• W2034142713 creator A5077240172 @default.
• W2034142713 creator A5089608970 @default.
• W2034142713 date "2014-07-26" @default.
• W2034142713 modified "2023-10-16" @default.
• W2034142713 title "A novel FGF2 antagonist peptide P8 with potent antiproliferation activity" @default.
• W2034142713 cites W1963805168 @default.
• W2034142713 cites W1968031805 @default.
• W2034142713 cites W1982887112 @default.
• W2034142713 cites W1988476050 @default.
• W2034142713 cites W1994996633 @default.
• W2034142713 cites W2005117549 @default.
• W2034142713 cites W2011566841 @default.
• W2034142713 cites W2012179510 @default.
• W2034142713 cites W2024712656 @default.
• W2034142713 cites W2032619835 @default.
• W2034142713 cites W2041680877 @default.
• W2034142713 cites W2047942701 @default.
• W2034142713 cites W2050518514 @default.
• W2034142713 cites W2058239412 @default.
• W2034142713 cites W2058509873 @default.
• W2034142713 cites W2064129448 @default.
• W2034142713 cites W2066073800 @default.
• W2034142713 cites W2077246243 @default.
• W2034142713 cites W2077552610 @default.
• W2034142713 cites W2077804275 @default.
• W2034142713 cites W2093972121 @default.
• W2034142713 cites W2138178479 @default.
• W2034142713 cites W2144780216 @default.
• W2034142713 cites W2165626977 @default.
• W2034142713 cites W2166699847 @default.
• W2034142713 cites W2334880322 @default.
• W2034142713 cites W2403815535 @default.
• W2034142713 doi "https://doi.org/10.1007/s13277-014-2356-4" @default.
• W2034142713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25062723" @default.
• W2034142713 hasPublicationYear "2014" @default.
• W2034142713 type Work @default.
• W2034142713 sameAs 2034142713 @default.
• W2034142713 citedByCount "8" @default.
• W2034142713 countsByYear W20341427132015 @default.
• W2034142713 countsByYear W20341427132016 @default.
• W2034142713 countsByYear W20341427132018 @default.
• W2034142713 countsByYear W20341427132019 @default.
• W2034142713 countsByYear W20341427132020 @default.
• W2034142713 crossrefType "journal-article" @default.
• W2034142713 hasAuthorship W2034142713A5010566551 @default.
• W2034142713 hasAuthorship W2034142713A5011740024 @default.
• W2034142713 hasAuthorship W2034142713A5014656305 @default.
• W2034142713 hasAuthorship W2034142713A5017441654 @default.
• W2034142713 hasAuthorship W2034142713A5033845983 @default.
• W2034142713 hasAuthorship W2034142713A5038617111 @default.
• W2034142713 hasAuthorship W2034142713A5046078938 @default.
• W2034142713 hasAuthorship W2034142713A5062336405 @default.
• W2034142713 hasAuthorship W2034142713A5074286511 @default.
• W2034142713 hasAuthorship W2034142713A5077240172 @default.
• W2034142713 hasAuthorship W2034142713A5089608970 @default.
• W2034142713 hasConcept C11960822 @default.
• W2034142713 hasConcept C13935069 @default.
• W2034142713 hasConcept C170493617 @default.
• W2034142713 hasConcept C185592680 @default.
• W2034142713 hasConcept C202751555 @default.
• W2034142713 hasConcept C2776885963 @default.
• W2034142713 hasConcept C2779281246 @default.
• W2034142713 hasConcept C2780381497 @default.
• W2034142713 hasConcept C49418065 @default.
• W2034142713 hasConcept C502942594 @default.
• W2034142713 hasConcept C55493867 @default.
• W2034142713 hasConcept C57074206 @default.
• W2034142713 hasConcept C74373430 @default.
• W2034142713 hasConcept C82867764 @default.
• W2034142713 hasConcept C86803240 @default.
• W2034142713 hasConcept C95444343 @default.
• W2034142713 hasConceptScore W2034142713C11960822 @default.
• W2034142713 hasConceptScore W2034142713C13935069 @default.
• W2034142713 hasConceptScore W2034142713C170493617 @default.
• W2034142713 hasConceptScore W2034142713C185592680 @default.
• W2034142713 hasConceptScore W2034142713C202751555 @default.
• W2034142713 hasConceptScore W2034142713C2776885963 @default.
• W2034142713 hasConceptScore W2034142713C2779281246 @default.
• W2034142713 hasConceptScore W2034142713C2780381497 @default.
• W2034142713 hasConceptScore W2034142713C49418065 @default.
• W2034142713 hasConceptScore W2034142713C502942594 @default.
• W2034142713 hasConceptScore W2034142713C55493867 @default.
• W2034142713 hasConceptScore W2034142713C57074206 @default.
• W2034142713 hasConceptScore W2034142713C74373430 @default.
• W2034142713 hasConceptScore W2034142713C82867764 @default.
• W2034142713 hasConceptScore W2034142713C86803240 @default.
• W2034142713 hasConceptScore W2034142713C95444343 @default.

• next