FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034142923> ?p ?o ?g. }

• W2034142923 endingPage "4360" @default.
• W2034142923 startingPage "4354" @default.
• W2034142923 abstract "Abstract There is no standard therapy for steroid-refractory chronic graft-versus-host disease (GVHD). This problem is particularly daunting in children with chronic GVHD, whereby the effects of the disease and its treatment may impair normal growth and development. Children are also particularly vulnerable to failure and/or toxicity of therapy; for example, joint contractures or joint damage may result in life-long disability. The Pediatric Blood and Marrow Transplant Consortium performed a phase 2 trial of pentostatin for steroid-refractory chronic GVHD in 51 children (median age, 9.8 years) from 24 institutions. Overall response was 53% (95% confidence interval, 40%-64%), with a response of 59% (95% confidence interval, 42%-75%) in sclerosis. Thirteen subjects (25%) had toxicity requiring them to stop pentostatin. The drug had a significant steroid-sparing effect in those that responded. A trend was also observed toward increased survival at 3 years in responders versus nonresponders (69% vs 50%; P = .06). The intravenous administration of the drug ensures compliance in a patient group in which oral therapy is difficult to monitor. Pentostatin has activity in refractory chronic GVHD in children, and future studies, including treatment of children newly diagnosed with high-risk chronic GVHD, are warranted. The trial was registered at www.Clinicaltrials.gov as #NCT00144430." @default.
• W2034142923 created "2016-06-24" @default.
• W2034142923 creator A5007378307 @default.
• W2034142923 creator A5008479139 @default.
• W2034142923 creator A5014556553 @default.
• W2034142923 creator A5023074568 @default.
• W2034142923 creator A5026879640 @default.
• W2034142923 creator A5031592776 @default.
• W2034142923 creator A5034117075 @default.
• W2034142923 creator A5053988910 @default.
• W2034142923 creator A5059298173 @default.
• W2034142923 creator A5069919013 @default.
• W2034142923 date "2009-11-12" @default.
• W2034142923 modified "2023-10-13" @default.
• W2034142923 title "Evaluation of pentostatin in corticosteroid-refractory chronic graft-versus-host disease in children: a Pediatric Blood and Marrow Transplant Consortium study" @default.
• W2034142923 cites W1527070137 @default.
• W2034142923 cites W1973617793 @default.
• W2034142923 cites W1974299244 @default.
• W2034142923 cites W1979522386 @default.
• W2034142923 cites W1980924218 @default.
• W2034142923 cites W1982914579 @default.
• W2034142923 cites W1993797289 @default.
• W2034142923 cites W1995061395 @default.
• W2034142923 cites W1995326684 @default.
• W2034142923 cites W2010965954 @default.
• W2034142923 cites W2020377341 @default.
• W2034142923 cites W2028590977 @default.
• W2034142923 cites W2041548911 @default.
• W2034142923 cites W2062576298 @default.
• W2034142923 cites W2072277949 @default.
• W2034142923 cites W2076964056 @default.
• W2034142923 cites W2082167435 @default.
• W2034142923 cites W2090019066 @default.
• W2034142923 cites W2102474483 @default.
• W2034142923 cites W2107441545 @default.
• W2034142923 cites W2109346271 @default.
• W2034142923 cites W2110395869 @default.
• W2034142923 cites W2118592731 @default.
• W2034142923 cites W2126128896 @default.
• W2034142923 cites W2129128251 @default.
• W2034142923 cites W2142189182 @default.
• W2034142923 cites W2143436585 @default.
• W2034142923 cites W2146129821 @default.
• W2034142923 cites W2147300036 @default.
• W2034142923 cites W2148922588 @default.
• W2034142923 cites W2166670863 @default.
• W2034142923 cites W2170433336 @default.
• W2034142923 cites W2328976528 @default.
• W2034142923 cites W2618073389 @default.
• W2034142923 cites W4251084195 @default.
• W2034142923 doi "https://doi.org/10.1182/blood-2009-05-224840" @default.
• W2034142923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19745067" @default.
• W2034142923 hasPublicationYear "2009" @default.
• W2034142923 type Work @default.
• W2034142923 sameAs 2034142923 @default.
• W2034142923 citedByCount "43" @default.
• W2034142923 countsByYear W20341429232012 @default.
• W2034142923 countsByYear W20341429232013 @default.
• W2034142923 countsByYear W20341429232014 @default.
• W2034142923 countsByYear W20341429232015 @default.
• W2034142923 countsByYear W20341429232016 @default.
• W2034142923 countsByYear W20341429232017 @default.
• W2034142923 countsByYear W20341429232018 @default.
• W2034142923 countsByYear W20341429232019 @default.
• W2034142923 countsByYear W20341429232020 @default.
• W2034142923 countsByYear W20341429232021 @default.
• W2034142923 countsByYear W20341429232022 @default.
• W2034142923 countsByYear W20341429232023 @default.
• W2034142923 crossrefType "journal-article" @default.
• W2034142923 hasAuthorship W2034142923A5007378307 @default.
• W2034142923 hasAuthorship W2034142923A5008479139 @default.
• W2034142923 hasAuthorship W2034142923A5014556553 @default.
• W2034142923 hasAuthorship W2034142923A5023074568 @default.
• W2034142923 hasAuthorship W2034142923A5026879640 @default.
• W2034142923 hasAuthorship W2034142923A5031592776 @default.
• W2034142923 hasAuthorship W2034142923A5034117075 @default.
• W2034142923 hasAuthorship W2034142923A5053988910 @default.
• W2034142923 hasAuthorship W2034142923A5059298173 @default.
• W2034142923 hasAuthorship W2034142923A5069919013 @default.
• W2034142923 hasBestOaLocation W20341429231 @default.
• W2034142923 hasConcept C121332964 @default.
• W2034142923 hasConcept C126322002 @default.
• W2034142923 hasConcept C141071460 @default.
• W2034142923 hasConcept C142424586 @default.
• W2034142923 hasConcept C2775952470 @default.
• W2034142923 hasConcept C2779338263 @default.
• W2034142923 hasConcept C2779972918 @default.
• W2034142923 hasConcept C2780653079 @default.
• W2034142923 hasConcept C2911091166 @default.
• W2034142923 hasConcept C44249647 @default.
• W2034142923 hasConcept C71924100 @default.
• W2034142923 hasConcept C87355193 @default.
• W2034142923 hasConceptScore W2034142923C121332964 @default.
• W2034142923 hasConceptScore W2034142923C126322002 @default.
• W2034142923 hasConceptScore W2034142923C141071460 @default.
• W2034142923 hasConceptScore W2034142923C142424586 @default.
• W2034142923 hasConceptScore W2034142923C2775952470 @default.
• W2034142923 hasConceptScore W2034142923C2779338263 @default.

• next