FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034143577> ?p ?o ?g. }

• W2034143577 endingPage "102" @default.
• W2034143577 startingPage "93" @default.
• W2034143577 abstract "Maturation of stem cells or precursor cells is associated with the acquisition of certain properties finally resulting in specifically functional cell types within the diverse tissues. This maturation process requires distinct steps of differentiation and is accompanied by a constantly increasing process of aging paralleled by a progressively reduced proliferative capacity. The eventually growth arrested and terminally differentiated cells perform their appropriate specific functions associated with developing senescence by STASIS (stress or aberrant signaling-inducing senescence) and/or by replicative senescence. Finally, elimination via apoptosis concludes their life span. However, nature also provides a surprise within this concept of life: Sometimes, differentiation and aging steps are reversible. A biological phenomenon of completely reversible differentiation events has been characterized as retrodifferentiation rather than dedifferentiation. Thus, all morphological and functional properties of retrodifferentiated and previously more undifferentiated cells are indistinguishable. Consequently, reversible differentiation may simultaneously be associated with a reversibility of the aging process and therefore, contributes to longevity and rejuvenation. Tissue renewals or regenerative potential for tissue-specific requirements, if not sufficiently compensated by the appropriate stem cells, may necessitate the generation of undifferentiated precursors by retrodifferentiation followed by a subsequent transdifferentiation process with the consequence of cell type conversion which also includes the risk for tumor development. This interference with the normal biological clock mediated by threshold effects in certain individual cells, raises important questions: What signals trigger retrodifferentiation and what would be the finite life span of cells with a retrodifferentiation capacity?" @default.
• W2034143577 created "2016-06-24" @default.
• W2034143577 creator A5036956314 @default.
• W2034143577 date "2005-08-01" @default.
• W2034143577 modified "2023-09-26" @default.
• W2034143577 title "Retrodifferentiation and reversibility of aging: forever young?" @default.
• W2034143577 cites W1501666754 @default.
• W2034143577 cites W1510919372 @default.
• W2034143577 cites W1516030147 @default.
• W2034143577 cites W1582530932 @default.
• W2034143577 cites W1641750848 @default.
• W2034143577 cites W1813092835 @default.
• W2034143577 cites W1845992048 @default.
• W2034143577 cites W1942708553 @default.
• W2034143577 cites W1945571160 @default.
• W2034143577 cites W1970587959 @default.
• W2034143577 cites W1973852526 @default.
• W2034143577 cites W1974540717 @default.
• W2034143577 cites W1977322085 @default.
• W2034143577 cites W1977472414 @default.
• W2034143577 cites W1986178447 @default.
• W2034143577 cites W1989145823 @default.
• W2034143577 cites W1989599224 @default.
• W2034143577 cites W1990316794 @default.
• W2034143577 cites W1990559952 @default.
• W2034143577 cites W1993151115 @default.
• W2034143577 cites W1993282564 @default.
• W2034143577 cites W1994362027 @default.
• W2034143577 cites W1995149610 @default.
• W2034143577 cites W1999277508 @default.
• W2034143577 cites W1999872096 @default.
• W2034143577 cites W2001692018 @default.
• W2034143577 cites W2007065677 @default.
• W2034143577 cites W2008418226 @default.
• W2034143577 cites W2011368229 @default.
• W2034143577 cites W2011543201 @default.
• W2034143577 cites W2012760766 @default.
• W2034143577 cites W2014548112 @default.
• W2034143577 cites W2019687443 @default.
• W2034143577 cites W2019861301 @default.
• W2034143577 cites W2020485023 @default.
• W2034143577 cites W2022487205 @default.
• W2034143577 cites W2022525159 @default.
• W2034143577 cites W2026938894 @default.
• W2034143577 cites W2027854877 @default.
• W2034143577 cites W2034300935 @default.
• W2034143577 cites W2036185366 @default.
• W2034143577 cites W2040016991 @default.
• W2034143577 cites W2041198010 @default.
• W2034143577 cites W2041809928 @default.
• W2034143577 cites W2046630742 @default.
• W2034143577 cites W2051521887 @default.
• W2034143577 cites W2056976662 @default.
• W2034143577 cites W2057557981 @default.
• W2034143577 cites W2058333864 @default.
• W2034143577 cites W2063266199 @default.
• W2034143577 cites W2064732318 @default.
• W2034143577 cites W2066406029 @default.
• W2034143577 cites W2068046748 @default.
• W2034143577 cites W2073760442 @default.
• W2034143577 cites W2078082552 @default.
• W2034143577 cites W2079250143 @default.
• W2034143577 cites W2080136436 @default.
• W2034143577 cites W2084282541 @default.
• W2034143577 cites W2086992094 @default.
• W2034143577 cites W2091309613 @default.
• W2034143577 cites W2092238768 @default.
• W2034143577 cites W2092529030 @default.
• W2034143577 cites W2094165973 @default.
• W2034143577 cites W2094362923 @default.
• W2034143577 cites W2103735500 @default.
• W2034143577 cites W2107613496 @default.
• W2034143577 cites W2107905466 @default.
• W2034143577 cites W2108482850 @default.
• W2034143577 cites W2108490725 @default.
• W2034143577 cites W2111476141 @default.
• W2034143577 cites W2112671059 @default.
• W2034143577 cites W2120222695 @default.
• W2034143577 cites W2121119720 @default.
• W2034143577 cites W2122734844 @default.
• W2034143577 cites W2127310510 @default.
• W2034143577 cites W2141185701 @default.
• W2034143577 cites W2143629217 @default.
• W2034143577 cites W2143859021 @default.
• W2034143577 cites W2145345977 @default.
• W2034143577 cites W2157271021 @default.
• W2034143577 cites W2164269732 @default.
• W2034143577 cites W2168967097 @default.
• W2034143577 cites W2267298733 @default.
• W2034143577 cites W2331470056 @default.
• W2034143577 cites W4234670076 @default.
• W2034143577 doi "https://doi.org/10.1002/sita.200400054" @default.
• W2034143577 hasPublicationYear "2005" @default.
• W2034143577 type Work @default.
• W2034143577 sameAs 2034143577 @default.
• W2034143577 citedByCount "6" @default.
• W2034143577 countsByYear W20341435772015 @default.
• W2034143577 crossrefType "journal-article" @default.

• next