Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034143847> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2034143847 abstract "Previously published results from our laboratory indicate that injection of NMDA receptor antagonists into the dorsal hindbrain increase food intake and suggest that capsaicin-resistant (myelinated) vagal afferents terminals that express NMDA-type glutamate receptors participate in control of meal size. NMDA receptors are heteromeric ion channels incorporating distinct subunits, including NR1, NR2A, NR2B, NR2C and NR2D. The NMDA channel's electrical and signaling properties are determined by its NR2 subunit phenotype. In the present study we tested the hypothesis that myelinated vagal afferent neurons express different NMDAR NR2 subunits than non-myelinated neurons. Six-week-old male Sprague-Dawley rats received intraperitoneal injections of capsaicin or vehicle. Nodose ganglia were processed for with primary antibodies against the capsaicin receptor (VR1), and NR1, NR2B, NR2C, or NR2D NMDAR subunits. In vehicle-treated rats, at least 60% of all nodose vagal afferents were immunopositive for VR-1 and capsaicin treatment reduced VR1 immunoreactivity to 10%. Furthermore, capsaicin reduced the number of NMDA NR1 and NR2B subunit expressing neurons by at least 50%, while resulting in no detectable loss of NMDA NR2C or NR2D immunopositive neurons. Our results indicate that NMDA NR2C and NR2D subunit immunoreactivity in the nodose ganglia is limited to capsaicin-resistant myelinated vagal afferents. Taken collectively with previous behavioral findings, we hypothesize that NMDA NR2C and/or NR2D expressing vagal afferents may mediate increased food intake evoked by injection of NMDA antagonists into the hindbrain and may contribute to the control of meal size. Supported by NIH Grants DK52849 and NS20561 and Poncin Scholarship 2006." @default.
- W2034143847 created "2016-06-24" @default.
- W2034143847 creator A5023201737 @default.
- W2034143847 creator A5053734424 @default.
- W2034143847 creator A5078960434 @default.
- W2034143847 date "2007-07-01" @default.
- W2034143847 modified "2023-10-14" @default.
- W2034143847 title "Hindbrain glutamatergic control of meal size: Evidence for participation of specific N-methyl-D-aspartate receptor (NMDAR) phenotypes on myelinated vagal afferent neurons." @default.
- W2034143847 doi "https://doi.org/10.1016/j.appet.2007.03.052" @default.
- W2034143847 hasPublicationYear "2007" @default.
- W2034143847 type Work @default.
- W2034143847 sameAs 2034143847 @default.
- W2034143847 citedByCount "0" @default.
- W2034143847 crossrefType "journal-article" @default.
- W2034143847 hasAuthorship W2034143847A5023201737 @default.
- W2034143847 hasAuthorship W2034143847A5053734424 @default.
- W2034143847 hasAuthorship W2034143847A5078960434 @default.
- W2034143847 hasConcept C126322002 @default.
- W2034143847 hasConcept C134018914 @default.
- W2034143847 hasConcept C169760540 @default.
- W2034143847 hasConcept C170493617 @default.
- W2034143847 hasConcept C185592680 @default.
- W2034143847 hasConcept C24998067 @default.
- W2034143847 hasConcept C2777075493 @default.
- W2034143847 hasConcept C2780051329 @default.
- W2034143847 hasConcept C2780648746 @default.
- W2034143847 hasConcept C2781404750 @default.
- W2034143847 hasConcept C2909127448 @default.
- W2034143847 hasConcept C529278444 @default.
- W2034143847 hasConcept C61174792 @default.
- W2034143847 hasConcept C67018056 @default.
- W2034143847 hasConcept C71924100 @default.
- W2034143847 hasConcept C86803240 @default.
- W2034143847 hasConceptScore W2034143847C126322002 @default.
- W2034143847 hasConceptScore W2034143847C134018914 @default.
- W2034143847 hasConceptScore W2034143847C169760540 @default.
- W2034143847 hasConceptScore W2034143847C170493617 @default.
- W2034143847 hasConceptScore W2034143847C185592680 @default.
- W2034143847 hasConceptScore W2034143847C24998067 @default.
- W2034143847 hasConceptScore W2034143847C2777075493 @default.
- W2034143847 hasConceptScore W2034143847C2780051329 @default.
- W2034143847 hasConceptScore W2034143847C2780648746 @default.
- W2034143847 hasConceptScore W2034143847C2781404750 @default.
- W2034143847 hasConceptScore W2034143847C2909127448 @default.
- W2034143847 hasConceptScore W2034143847C529278444 @default.
- W2034143847 hasConceptScore W2034143847C61174792 @default.
- W2034143847 hasConceptScore W2034143847C67018056 @default.
- W2034143847 hasConceptScore W2034143847C71924100 @default.
- W2034143847 hasConceptScore W2034143847C86803240 @default.
- W2034143847 hasLocation W20341438471 @default.
- W2034143847 hasOpenAccess W2034143847 @default.
- W2034143847 hasPrimaryLocation W20341438471 @default.
- W2034143847 hasRelatedWork W2008976175 @default.
- W2034143847 hasRelatedWork W2022694054 @default.
- W2034143847 hasRelatedWork W2028787575 @default.
- W2034143847 hasRelatedWork W2032086168 @default.
- W2034143847 hasRelatedWork W2034143847 @default.
- W2034143847 hasRelatedWork W2068467384 @default.
- W2034143847 hasRelatedWork W2317248201 @default.
- W2034143847 hasRelatedWork W2770921749 @default.
- W2034143847 hasRelatedWork W4226277652 @default.
- W2034143847 hasRelatedWork W54840840 @default.
- W2034143847 isParatext "false" @default.
- W2034143847 isRetracted "false" @default.
- W2034143847 magId "2034143847" @default.
- W2034143847 workType "article" @default.