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• W2034144737 endingPage "90" @default.
• W2034144737 startingPage "80" @default.
• W2034144737 abstract "Estrogens are an important class of steroid hormones, having multiple targets, in the body and brain, and exerting ubiquitous effects on behavior. At present, two estrogen receptors (ERα and β) have been cloned and sequenced in mammals. In the brain these receptors are regionally specific, but both have widespread distributions, which are largely non-overlapping. Given the newly emerging complexities of estrogen's mechanisms of action it is important to distinguish which pathways are involved in modifying which behaviors. We use a knockout mouse, lacking functional copies of the estrogen receptor α (ERα) gene, to study the mechanisms by which estrogens mediate behaviors. There are pronounced ramifications of ERα gene disruption on behavior. First, female ERα knockout (ERαKO) mice do not display normal feminine sexual behavior. Second, treatment of adult mice with androgens promotes masculine sexual behavior in both sexes. However, male-typical sexual behavior is severely compromised in male and female ERαKOs. Third, male ERαKOs do not exhibit the same social preferences for female mice as do wildtype (WT) littermates. Thus, the ERα is essential for normal expression of sexual behaviors. In addition, gonadectomized ERαKO and WT mice rapidly learn to escape from the Morris water maze. Exogenous estrogen treatment prevents WT females from learning this task, yet, has no effect in ERαKO mice, suggesting that estrogens effects on learning in adult females involves the ERα. Based on these data we hypothesize that ERα mediates many of the effects of estrogen on sexual behavior, learning, and memory." @default.
• W2034144737 created "2016-06-24" @default.
• W2034144737 creator A5042566768 @default.
• W2034144737 creator A5045746581 @default.
• W2034144737 creator A5050185147 @default.
• W2034144737 creator A5089602155 @default.
• W2034144737 date "1999-07-01" @default.
• W2034144737 modified "2023-09-26" @default.
• W2034144737 title "Sex with knockout models: behavioral studies of estrogen receptor α1Published on the World Wide Web on 26 April 1999.1" @default.
• W2034144737 cites W1541234884 @default.
• W2034144737 cites W1970892499 @default.
• W2034144737 cites W1974721202 @default.
• W2034144737 cites W1975123859 @default.
• W2034144737 cites W1978046402 @default.
• W2034144737 cites W1982038091 @default.
• W2034144737 cites W1982691907 @default.
• W2034144737 cites W1989347905 @default.
• W2034144737 cites W1996120399 @default.
• W2034144737 cites W1996471481 @default.
• W2034144737 cites W1996732665 @default.
• W2034144737 cites W1998443184 @default.
• W2034144737 cites W1998860461 @default.
• W2034144737 cites W1999962551 @default.
• W2034144737 cites W2000841514 @default.
• W2034144737 cites W2002275574 @default.
• W2034144737 cites W2007801101 @default.
• W2034144737 cites W2012425172 @default.
• W2034144737 cites W2017959247 @default.
• W2034144737 cites W2018570375 @default.
• W2034144737 cites W2019900112 @default.
• W2034144737 cites W2021620079 @default.
• W2034144737 cites W2023854454 @default.
• W2034144737 cites W2024566047 @default.
• W2034144737 cites W2025617136 @default.
• W2034144737 cites W2031326939 @default.
• W2034144737 cites W2031917138 @default.
• W2034144737 cites W2034959440 @default.
• W2034144737 cites W2037861701 @default.
• W2034144737 cites W2039523407 @default.
• W2034144737 cites W2042552774 @default.
• W2034144737 cites W2047695558 @default.
• W2034144737 cites W2047976019 @default.
• W2034144737 cites W2051596977 @default.
• W2034144737 cites W2052152815 @default.
• W2034144737 cites W2053608868 @default.
• W2034144737 cites W2055860149 @default.
• W2034144737 cites W2059477274 @default.
• W2034144737 cites W2061800243 @default.
• W2034144737 cites W2065912927 @default.
• W2034144737 cites W2069752587 @default.
• W2034144737 cites W2071308804 @default.
• W2034144737 cites W2073353512 @default.
• W2034144737 cites W2073436852 @default.
• W2034144737 cites W2073883348 @default.
• W2034144737 cites W2074746487 @default.
• W2034144737 cites W2075873400 @default.
• W2034144737 cites W2080487349 @default.
• W2034144737 cites W2084610097 @default.
• W2034144737 cites W2085603542 @default.
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• W2034144737 cites W2100898329 @default.
• W2034144737 cites W2104594573 @default.
• W2034144737 cites W2111072866 @default.
• W2034144737 cites W2127905906 @default.
• W2034144737 cites W2128681733 @default.
• W2034144737 cites W2130244428 @default.
• W2034144737 cites W2130286868 @default.
• W2034144737 cites W2134408917 @default.
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• W2034144737 cites W2141269411 @default.
• W2034144737 cites W2145865543 @default.
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• W2034144737 cites W2161623422 @default.
• W2034144737 cites W2321613759 @default.
• W2034144737 cites W2407987762 @default.
• W2034144737 cites W385530932 @default.
• W2034144737 cites W4241613113 @default.
• W2034144737 cites W4248408063 @default.
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• W2034144737 doi "https://doi.org/10.1016/s0006-8993(99)01452-3" @default.
• W2034144737 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10448199" @default.
• W2034144737 hasPublicationYear "1999" @default.
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