FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034145254> ?p ?o ?g. }

• W2034145254 endingPage "454" @default.
• W2034145254 startingPage "447" @default.
• W2034145254 abstract "The 5-HT2A receptor is one of the most interesting targets within the serotonergic system because it is involved in a number of important physiological processes and diseases. [18F]MH.MZ, a 5-HT2A antagonistic receptor ligand, is labeled by 18F-fluoroalkylation of the corresponding desmethyl analogue MDL 105725 with 2-[18F]fluoroethyltosylate ([18F]FETos). In vitro binding experiments were performed to test selectivity toward a broad spectrum of neuroreceptors by radioligand binding assays. Moreover, first micro-positron emission tomography (μPET) experiments, ex vivo organ biodistribution, blood cell and protein binding and brain metabolism studies of [18F]MH.MZ were carried out in rats. [18F]MH.MZ showed a Ki of 3 nM toward the 5-HT2A receptor and no appreciable affinity for a variety of receptors and transporters. Ex vivo biodistribution as well as μPET showed highest brain uptake at ∼5 min p.i. and steady state after ∼30 min p.i. While [18F]MH.MZ undergoes extensive first-pass metabolism which significantly reduces its bioavailability, it is insignificantly metabolized within the brain. The binding potential in the rat frontal cortex is 1.45, whereas the cortex to cerebellum ratio was determined to be 2.7 after ∼30 min. Results from μPET measurements of [18F]MH.MZ are in no way inferior to data known for [11C]MDL 100907 at least in rats. [18F]MH.MZ appears to be a highly potent and selective serotonergic PET ligand in small animals." @default.
• W2034145254 created "2016-06-24" @default.
• W2034145254 creator A5014835551 @default.
• W2034145254 creator A5031340154 @default.
• W2034145254 creator A5040501350 @default.
• W2034145254 creator A5048488306 @default.
• W2034145254 creator A5051811076 @default.
• W2034145254 creator A5087349845 @default.
• W2034145254 date "2009-05-01" @default.
• W2034145254 modified "2023-10-18" @default.
• W2034145254 title "Preliminary in vivo and ex vivo evaluation of the 5-HT2A imaging probe [18F]MH.MZ" @default.
• W2034145254 cites W1978964535 @default.
• W2034145254 cites W1981862550 @default.
• W2034145254 cites W1984754451 @default.
• W2034145254 cites W1998069074 @default.
• W2034145254 cites W2015300638 @default.
• W2034145254 cites W2019400297 @default.
• W2034145254 cites W2024333989 @default.
• W2034145254 cites W2026798813 @default.
• W2034145254 cites W2027461536 @default.
• W2034145254 cites W2033424381 @default.
• W2034145254 cites W2037625882 @default.
• W2034145254 cites W2039767420 @default.
• W2034145254 cites W2050609182 @default.
• W2034145254 cites W2081880500 @default.
• W2034145254 cites W2085302232 @default.
• W2034145254 cites W2089542831 @default.
• W2034145254 cites W2103186609 @default.
• W2034145254 cites W2106531784 @default.
• W2034145254 cites W2137741077 @default.
• W2034145254 cites W2307936244 @default.
• W2034145254 cites W2333694673 @default.
• W2034145254 doi "https://doi.org/10.1016/j.nucmedbio.2009.01.012" @default.
• W2034145254 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19423013" @default.
• W2034145254 hasPublicationYear "2009" @default.
• W2034145254 type Work @default.
• W2034145254 sameAs 2034145254 @default.
• W2034145254 citedByCount "23" @default.
• W2034145254 countsByYear W20341452542012 @default.
• W2034145254 countsByYear W20341452542013 @default.
• W2034145254 countsByYear W20341452542015 @default.
• W2034145254 countsByYear W20341452542017 @default.
• W2034145254 countsByYear W20341452542018 @default.
• W2034145254 countsByYear W20341452542019 @default.
• W2034145254 countsByYear W20341452542021 @default.
• W2034145254 countsByYear W20341452542022 @default.
• W2034145254 crossrefType "journal-article" @default.
• W2034145254 hasAuthorship W2034145254A5014835551 @default.
• W2034145254 hasAuthorship W2034145254A5031340154 @default.
• W2034145254 hasAuthorship W2034145254A5040501350 @default.
• W2034145254 hasAuthorship W2034145254A5048488306 @default.
• W2034145254 hasAuthorship W2034145254A5051811076 @default.
• W2034145254 hasAuthorship W2034145254A5087349845 @default.
• W2034145254 hasConcept C116569031 @default.
• W2034145254 hasConcept C150903083 @default.
• W2034145254 hasConcept C169760540 @default.
• W2034145254 hasConcept C170493617 @default.
• W2034145254 hasConcept C185592680 @default.
• W2034145254 hasConcept C202751555 @default.
• W2034145254 hasConcept C207001950 @default.
• W2034145254 hasConcept C26291073 @default.
• W2034145254 hasConcept C2775842073 @default.
• W2034145254 hasConcept C2775864247 @default.
• W2034145254 hasConcept C2777807558 @default.
• W2034145254 hasConcept C37000724 @default.
• W2034145254 hasConcept C55493867 @default.
• W2034145254 hasConcept C67847695 @default.
• W2034145254 hasConcept C86803240 @default.
• W2034145254 hasConceptScore W2034145254C116569031 @default.
• W2034145254 hasConceptScore W2034145254C150903083 @default.
• W2034145254 hasConceptScore W2034145254C169760540 @default.
• W2034145254 hasConceptScore W2034145254C170493617 @default.
• W2034145254 hasConceptScore W2034145254C185592680 @default.
• W2034145254 hasConceptScore W2034145254C202751555 @default.
• W2034145254 hasConceptScore W2034145254C207001950 @default.
• W2034145254 hasConceptScore W2034145254C26291073 @default.
• W2034145254 hasConceptScore W2034145254C2775842073 @default.
• W2034145254 hasConceptScore W2034145254C2775864247 @default.
• W2034145254 hasConceptScore W2034145254C2777807558 @default.
• W2034145254 hasConceptScore W2034145254C37000724 @default.
• W2034145254 hasConceptScore W2034145254C55493867 @default.
• W2034145254 hasConceptScore W2034145254C67847695 @default.
• W2034145254 hasConceptScore W2034145254C86803240 @default.
• W2034145254 hasIssue "4" @default.
• W2034145254 hasLocation W20341452541 @default.
• W2034145254 hasLocation W20341452542 @default.
• W2034145254 hasOpenAccess W2034145254 @default.
• W2034145254 hasPrimaryLocation W20341452541 @default.
• W2034145254 hasRelatedWork W1828383458 @default.
• W2034145254 hasRelatedWork W1987129921 @default.
• W2034145254 hasRelatedWork W2033759470 @default.
• W2034145254 hasRelatedWork W2065922695 @default.
• W2034145254 hasRelatedWork W2073562664 @default.
• W2034145254 hasRelatedWork W2410935429 @default.
• W2034145254 hasRelatedWork W26368345 @default.
• W2034145254 hasRelatedWork W2943988274 @default.
• W2034145254 hasRelatedWork W3097405835 @default.
• W2034145254 hasRelatedWork W4206347286 @default.

• next