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- W2034145781 endingPage "153" @default.
- W2034145781 startingPage "144" @default.
- W2034145781 abstract "Extracellular matrix is generally increased in asthma, causing thickening of the airways which may either increase or decrease airway responsiveness, depending on the mechanical requirements of the deposited matrix. However, in vitro studies have shown that the altered extracellular matrix produced by asthmatic airway smooth muscle cells is able to induce increased proliferation of non-asthmatic smooth muscle cells, which is a process believed to contribute to airway hyper-responsiveness in asthma. Elastin is an extracellular matrix protein that is altered in asthmatic airways, but there has been no systematic investigation of the functional effect of these changes. This review reveals divergent reports of the state of elastin in the airway wall in asthma. In some layers of the airway it has been described as increased, decreased and/or fragmented, or unchanged. There is also considerable evidence for an imbalance of matrix metalloproteinases, which degrade elastin, and their respective inhibitors the tissue inhibitors of metalloproteinases, which collectively help to explain observations of both increased elastin and elastin fragments. A loss of lung elastic recoil in asthma suggests a mechanical role for disordered elastin in the aetiology of the disease, but extensive studies of elastin in other tissues show that elastin fragments elicit cellular effects such as increased proliferation and inflammation. This review summarises the current understanding of the role of elastin in the asthmatic airway." @default.
- W2034145781 created "2016-06-24" @default.
- W2034145781 creator A5007081664 @default.
- W2034145781 creator A5072324055 @default.
- W2034145781 creator A5089331990 @default.
- W2034145781 date "2012-04-01" @default.
- W2034145781 modified "2023-09-26" @default.
- W2034145781 title "Elastin in asthma" @default.
- W2034145781 cites W1507468262 @default.
- W2034145781 cites W1553206147 @default.
- W2034145781 cites W1596187918 @default.
- W2034145781 cites W1821528780 @default.
- W2034145781 cites W1965751894 @default.
- W2034145781 cites W1967722955 @default.
- W2034145781 cites W1968384520 @default.
- W2034145781 cites W1968575852 @default.
- W2034145781 cites W1969306156 @default.
- W2034145781 cites W1969692558 @default.
- W2034145781 cites W1969966409 @default.
- W2034145781 cites W1973895231 @default.
- W2034145781 cites W1974935476 @default.
- W2034145781 cites W1977123504 @default.
- W2034145781 cites W1979914322 @default.
- W2034145781 cites W1985187870 @default.
- W2034145781 cites W1988784161 @default.
- W2034145781 cites W1988910126 @default.
- W2034145781 cites W1988967646 @default.
- W2034145781 cites W1989423035 @default.
- W2034145781 cites W1997543277 @default.
- W2034145781 cites W2000856419 @default.
- W2034145781 cites W2002592975 @default.
- W2034145781 cites W2007441851 @default.
- W2034145781 cites W2013848838 @default.
- W2034145781 cites W2016025974 @default.
- W2034145781 cites W2018123076 @default.
- W2034145781 cites W2018905465 @default.
- W2034145781 cites W2026987057 @default.
- W2034145781 cites W2028630600 @default.
- W2034145781 cites W2029289936 @default.
- W2034145781 cites W2030833580 @default.
- W2034145781 cites W2030869337 @default.
- W2034145781 cites W2031020853 @default.
- W2034145781 cites W2031097767 @default.
- W2034145781 cites W2031304251 @default.
- W2034145781 cites W2031471867 @default.
- W2034145781 cites W2031654076 @default.
- W2034145781 cites W2032214984 @default.
- W2034145781 cites W2033392452 @default.
- W2034145781 cites W2039213842 @default.
- W2034145781 cites W2040541849 @default.
- W2034145781 cites W2041029169 @default.
- W2034145781 cites W2043327727 @default.
- W2034145781 cites W2043710834 @default.
- W2034145781 cites W2044164946 @default.
- W2034145781 cites W2044734165 @default.
- W2034145781 cites W2045404555 @default.
- W2034145781 cites W2048405500 @default.
- W2034145781 cites W2049422998 @default.
- W2034145781 cites W2049641633 @default.
- W2034145781 cites W2050198557 @default.
- W2034145781 cites W2051331775 @default.
- W2034145781 cites W2053444611 @default.
- W2034145781 cites W2053724325 @default.
- W2034145781 cites W2054027163 @default.
- W2034145781 cites W2057179232 @default.
- W2034145781 cites W2058277254 @default.
- W2034145781 cites W2059264314 @default.
- W2034145781 cites W2059541269 @default.
- W2034145781 cites W2064985248 @default.
- W2034145781 cites W2065629589 @default.
- W2034145781 cites W2067914624 @default.
- W2034145781 cites W2069267570 @default.
- W2034145781 cites W2070056021 @default.
- W2034145781 cites W2072974313 @default.
- W2034145781 cites W2075806746 @default.
- W2034145781 cites W2076259435 @default.
- W2034145781 cites W2077332632 @default.
- W2034145781 cites W2079893197 @default.
- W2034145781 cites W2085138849 @default.
- W2034145781 cites W2085320561 @default.
- W2034145781 cites W2086596741 @default.
- W2034145781 cites W2087763300 @default.
- W2034145781 cites W2092902440 @default.
- W2034145781 cites W2094546356 @default.
- W2034145781 cites W2094742854 @default.
- W2034145781 cites W2099429774 @default.
- W2034145781 cites W2099524467 @default.
- W2034145781 cites W2105216609 @default.
- W2034145781 cites W2105854015 @default.
- W2034145781 cites W2109324313 @default.
- W2034145781 cites W2112801222 @default.
- W2034145781 cites W2116717938 @default.
- W2034145781 cites W2119523001 @default.
- W2034145781 cites W2121317825 @default.
- W2034145781 cites W2121464855 @default.
- W2034145781 cites W2122243862 @default.
- W2034145781 cites W2123077778 @default.
- W2034145781 cites W2129137758 @default.