FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034146546> ?p ?o ?g. }

• W2034146546 abstract "Tetanus toxin (about 1 nM) inhibits 70% of the nicotine-evoked release of catecholamines from intact adrenal medullary chromaffin cells after 20 h of incubation and 30% of the K(+)-evoked release. Inhibition of Ca(2+)-evoked release from detergent-permeabilized cells requires higher concentrations of toxin (about 1 microM) toxin, but is maximal after 12 min. Preincubation of the intact cells with ganglioside GT1 in the absence of toxin also inhibits evoked secretion. 125I-labelled toxin bound specifically to these cells; the binding capacity was greater at pH 6 (about 1 pmol toxin/mg cell protein) than at pH 7.4 (about 0.25 pmol). In both cases there were at least two binding components: one of high affinity (Kd about 1 nM) accounting for about 20% of total binding and one of lower affinity (Kd 10-20 nM). Preincubation of the cells with ganglioside increased the binding capacity, but did not affect the Kd of the lower affinity component. Similar observations could be made when binding was measured immunocytochemically. Extraction of gangliosides from chromaffin cells and overlay experiments with radiolabelled toxin showed that, as well as GM3, the major ganglioside component of chromaffin cell membranes, a ganglioside having the chromatographic mobility of GT1 was a major ligand for toxin." @default.
• W2034146546 created "2016-06-24" @default.
• W2034146546 creator A5018908340 @default.
• W2034146546 creator A5049471699 @default.
• W2034146546 creator A5078365739 @default.
• W2034146546 creator A5083805010 @default.
• W2034146546 date "1992-11-01" @default.
• W2034146546 modified "2023-09-27" @default.
• W2034146546 title "The interaction of tetanus toxin with intact bovine adrenal chromaffin cells: Binding of toxin and subsequent inhibition of catecholamine release" @default.
• W2034146546 cites W1495517783 @default.
• W2034146546 cites W1495524572 @default.
• W2034146546 cites W1536299500 @default.
• W2034146546 cites W1552103205 @default.
• W2034146546 cites W1562285763 @default.
• W2034146546 cites W1604922980 @default.
• W2034146546 cites W1609177386 @default.
• W2034146546 cites W1768145043 @default.
• W2034146546 cites W180791406 @default.
• W2034146546 cites W1975773005 @default.
• W2034146546 cites W1978667112 @default.
• W2034146546 cites W1985493073 @default.
• W2034146546 cites W1987725158 @default.
• W2034146546 cites W1994283509 @default.
• W2034146546 cites W1997507057 @default.
• W2034146546 cites W1999484947 @default.
• W2034146546 cites W2001073768 @default.
• W2034146546 cites W2003481350 @default.
• W2034146546 cites W2013137776 @default.
• W2034146546 cites W2019325958 @default.
• W2034146546 cites W2023816853 @default.
• W2034146546 cites W2025609921 @default.
• W2034146546 cites W2026375108 @default.
• W2034146546 cites W2031156829 @default.
• W2034146546 cites W2031787229 @default.
• W2034146546 cites W2034708224 @default.
• W2034146546 cites W2034994589 @default.
• W2034146546 cites W2037696797 @default.
• W2034146546 cites W2049949371 @default.
• W2034146546 cites W2061893905 @default.
• W2034146546 cites W2067983946 @default.
• W2034146546 cites W2073672089 @default.
• W2034146546 cites W2074443036 @default.
• W2034146546 cites W2076140025 @default.
• W2034146546 cites W2076463633 @default.
• W2034146546 cites W2078001609 @default.
• W2034146546 cites W2084786156 @default.
• W2034146546 cites W2089264852 @default.
• W2034146546 cites W2091432500 @default.
• W2034146546 cites W2093540558 @default.
• W2034146546 cites W2100106192 @default.
• W2034146546 cites W2105433175 @default.
• W2034146546 cites W2120651407 @default.
• W2034146546 cites W2128440593 @default.
• W2034146546 cites W2128810977 @default.
• W2034146546 cites W2138352514 @default.
• W2034146546 cites W2154012391 @default.
• W2034146546 cites W2167722613 @default.
• W2034146546 cites W2404852962 @default.
• W2034146546 cites W241110173 @default.
• W2034146546 cites W28433706 @default.
• W2034146546 doi "https://doi.org/10.1016/0167-4889(92)90146-3" @default.
• W2034146546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1445928" @default.
• W2034146546 hasPublicationYear "1992" @default.
• W2034146546 type Work @default.
• W2034146546 sameAs 2034146546 @default.
• W2034146546 citedByCount "2" @default.
• W2034146546 crossrefType "journal-article" @default.
• W2034146546 hasAuthorship W2034146546A5018908340 @default.
• W2034146546 hasAuthorship W2034146546A5049471699 @default.
• W2034146546 hasAuthorship W2034146546A5078365739 @default.
• W2034146546 hasAuthorship W2034146546A5083805010 @default.
• W2034146546 hasConcept C134018914 @default.
• W2034146546 hasConcept C170493617 @default.
• W2034146546 hasConcept C185592680 @default.
• W2034146546 hasConcept C2775894120 @default.
• W2034146546 hasConcept C2777331542 @default.
• W2034146546 hasConcept C2777367657 @default.
• W2034146546 hasConcept C2777597313 @default.
• W2034146546 hasConcept C2780910648 @default.
• W2034146546 hasConcept C49773422 @default.
• W2034146546 hasConcept C55493867 @default.
• W2034146546 hasConcept C80631254 @default.
• W2034146546 hasConcept C86803240 @default.
• W2034146546 hasConceptScore W2034146546C134018914 @default.
• W2034146546 hasConceptScore W2034146546C170493617 @default.
• W2034146546 hasConceptScore W2034146546C185592680 @default.
• W2034146546 hasConceptScore W2034146546C2775894120 @default.
• W2034146546 hasConceptScore W2034146546C2777331542 @default.
• W2034146546 hasConceptScore W2034146546C2777367657 @default.
• W2034146546 hasConceptScore W2034146546C2777597313 @default.
• W2034146546 hasConceptScore W2034146546C2780910648 @default.
• W2034146546 hasConceptScore W2034146546C49773422 @default.
• W2034146546 hasConceptScore W2034146546C55493867 @default.
• W2034146546 hasConceptScore W2034146546C80631254 @default.
• W2034146546 hasConceptScore W2034146546C86803240 @default.
• W2034146546 hasLocation W20341465461 @default.
• W2034146546 hasLocation W20341465462 @default.
• W2034146546 hasOpenAccess W2034146546 @default.
• W2034146546 hasPrimaryLocation W20341465461 @default.
• W2034146546 hasRelatedWork W17572923 @default.

• next