Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034146948> ?p ?o ?g. }
- W2034146948 endingPage "62" @default.
- W2034146948 startingPage "57" @default.
- W2034146948 abstract "Little is known about the role of glial cells in the striatum of chronic methamphetamine (METH) users. In this study, we immunohistochemically examined glial reactions in the striatum of chronic METH users who did not abstain from METH use and died of drug intoxication. Human glucose transporter 5 (hGLUT), a useful marker of microglia, and CR3.43, a major histocompatibility complex class II antigen specific for reactive microglia, were immunostained. Glial fibrillary acidic protein (GFAP) and S100Β were used for astrocyte immunohistochemistry. We analyzed 12 chronic METH users and 13 control subjects, and detected a 200–240% increase in the number of hGLUT5-positive cells in chronic METH users (p < 0.01). However, we did not detect any proliferation of CR3.43-positive cells. The number of GFAP-positive astrocytes increased, but this increase was not significant (p > 0.05). Moreover, S100B-positive cell density between the two groups was not significant (p > 0.05). This study demonstrates the absence of reactive gliosis in the striatum of chronic METH users who did not abstain for prolonged periods from METH use. The results suggest that chronic METH use by itself did not activate glial cells in humans and reactive gliosis may not be involved in the mechanism underlying the loss of control in drug intake, which is a characteristic feature of drug addiction." @default.
- W2034146948 created "2016-06-24" @default.
- W2034146948 creator A5022279233 @default.
- W2034146948 creator A5027921542 @default.
- W2034146948 creator A5029496020 @default.
- W2034146948 creator A5040084054 @default.
- W2034146948 creator A5071382481 @default.
- W2034146948 creator A5085340645 @default.
- W2034146948 date "2010-03-01" @default.
- W2034146948 modified "2023-09-24" @default.
- W2034146948 title "Microglial and astrocytic changes in the striatum of methamphetamine abusers" @default.
- W2034146948 cites W1497884244 @default.
- W2034146948 cites W1683600212 @default.
- W2034146948 cites W1974191118 @default.
- W2034146948 cites W1978916589 @default.
- W2034146948 cites W1980529612 @default.
- W2034146948 cites W1987350833 @default.
- W2034146948 cites W2006300717 @default.
- W2034146948 cites W2007383758 @default.
- W2034146948 cites W2009503318 @default.
- W2034146948 cites W2013045923 @default.
- W2034146948 cites W2014064744 @default.
- W2034146948 cites W2014488168 @default.
- W2034146948 cites W2017165365 @default.
- W2034146948 cites W2021479980 @default.
- W2034146948 cites W2023590101 @default.
- W2034146948 cites W2037074024 @default.
- W2034146948 cites W2039682406 @default.
- W2034146948 cites W2042735193 @default.
- W2034146948 cites W2063249182 @default.
- W2034146948 cites W2066790627 @default.
- W2034146948 cites W2068597263 @default.
- W2034146948 cites W2068872768 @default.
- W2034146948 cites W2070600101 @default.
- W2034146948 cites W2076013179 @default.
- W2034146948 cites W2079043089 @default.
- W2034146948 cites W2089155165 @default.
- W2034146948 cites W2090804892 @default.
- W2034146948 cites W2091073665 @default.
- W2034146948 cites W2091979210 @default.
- W2034146948 cites W2093100575 @default.
- W2034146948 cites W2093419170 @default.
- W2034146948 cites W2095169653 @default.
- W2034146948 cites W2098139332 @default.
- W2034146948 cites W2106287416 @default.
- W2034146948 cites W2117088742 @default.
- W2034146948 cites W2117691576 @default.
- W2034146948 cites W2121898255 @default.
- W2034146948 cites W2127338217 @default.
- W2034146948 cites W2130014240 @default.
- W2034146948 cites W2149954869 @default.
- W2034146948 cites W2160263038 @default.
- W2034146948 doi "https://doi.org/10.1016/j.legalmed.2009.11.001" @default.
- W2034146948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20110187" @default.
- W2034146948 hasPublicationYear "2010" @default.
- W2034146948 type Work @default.
- W2034146948 sameAs 2034146948 @default.
- W2034146948 citedByCount "73" @default.
- W2034146948 countsByYear W20341469482012 @default.
- W2034146948 countsByYear W20341469482013 @default.
- W2034146948 countsByYear W20341469482014 @default.
- W2034146948 countsByYear W20341469482015 @default.
- W2034146948 countsByYear W20341469482016 @default.
- W2034146948 countsByYear W20341469482017 @default.
- W2034146948 countsByYear W20341469482018 @default.
- W2034146948 countsByYear W20341469482019 @default.
- W2034146948 countsByYear W20341469482020 @default.
- W2034146948 countsByYear W20341469482021 @default.
- W2034146948 countsByYear W20341469482022 @default.
- W2034146948 countsByYear W20341469482023 @default.
- W2034146948 crossrefType "journal-article" @default.
- W2034146948 hasAuthorship W2034146948A5022279233 @default.
- W2034146948 hasAuthorship W2034146948A5027921542 @default.
- W2034146948 hasAuthorship W2034146948A5029496020 @default.
- W2034146948 hasAuthorship W2034146948A5040084054 @default.
- W2034146948 hasAuthorship W2034146948A5071382481 @default.
- W2034146948 hasAuthorship W2034146948A5085340645 @default.
- W2034146948 hasConcept C126322002 @default.
- W2034146948 hasConcept C142724271 @default.
- W2034146948 hasConcept C166940927 @default.
- W2034146948 hasConcept C178790620 @default.
- W2034146948 hasConcept C185592680 @default.
- W2034146948 hasConcept C203014093 @default.
- W2034146948 hasConcept C204232928 @default.
- W2034146948 hasConcept C2776914184 @default.
- W2034146948 hasConcept C2777542381 @default.
- W2034146948 hasConcept C2777682930 @default.
- W2034146948 hasConcept C2779830541 @default.
- W2034146948 hasConcept C2779989194 @default.
- W2034146948 hasConcept C2780062018 @default.
- W2034146948 hasConcept C2780114369 @default.
- W2034146948 hasConcept C2780376393 @default.
- W2034146948 hasConcept C2780495277 @default.
- W2034146948 hasConcept C2780884517 @default.
- W2034146948 hasConcept C513476851 @default.
- W2034146948 hasConcept C521977710 @default.
- W2034146948 hasConcept C529278444 @default.
- W2034146948 hasConcept C71924100 @default.