FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034147064> ?p ?o ?g. }

• W2034147064 endingPage "51" @default.
• W2034147064 startingPage "45" @default.
• W2034147064 abstract "The prion paradigm – the hypothesis that the seeded aggregation of certain proteins is key to understanding age-related neurodegenerative disorders – is evaluated in relation to recent studies and disease models; the paradigm suggests a unifying pathogenic principle with broad relevance to a large class of currently intractable diseases. There is growing speculation that the pathophysiological features common to age-related neurodegenerative disorders, including Alzheimer's and Parkinson's diseases, and prion infections, such as Creutzfeldt–Jakob disease, may be key to our understanding of these conditions. In this Review, Mathias Jucker and Lary Walker consider recent work on the parallels between the self-propagating and misfolding protein aggregates associated with neurodegeneration and the infectious and self-seeding activities of prions. They conclude that the 'prion paradigm' linking these two groups of diseases could lead to a better understanding of the pathology and possible approaches to therapy for diseases that have so far proved intractable. For several decades scientists have speculated that the key to understanding age-related neurodegenerative disorders may be found in the unusual biology of the prion diseases. Recently, owing largely to the advent of new disease models, this hypothesis has gained experimental momentum. In a remarkable variety of diseases, specific proteins have been found to misfold and aggregate into seeds that structurally corrupt like proteins, causing them to aggregate and form pathogenic assemblies ranging from small oligomers to large masses of amyloid. Proteinaceous seeds can therefore serve as self-propagating agents for the instigation and progression of disease. Alzheimer’s disease and other cerebral proteopathies seem to arise from the de novo misfolding and sustained corruption of endogenous proteins, whereas prion diseases can also be infectious in origin. However, the outcome in all cases is the functional compromise of the nervous system, because the aggregated proteins gain a toxic function and/or lose their normal function. As a unifying pathogenic principle, the prion paradigm suggests broadly relevant therapeutic directions for a large class of currently intractable diseases." @default.
• W2034147064 created "2016-06-24" @default.
• W2034147064 creator A5010409175 @default.
• W2034147064 creator A5017808777 @default.
• W2034147064 date "2013-09-04" @default.
• W2034147064 modified "2023-10-18" @default.
• W2034147064 title "Self-propagation of pathogenic protein aggregates in neurodegenerative diseases" @default.
• W2034147064 cites W1493986974 @default.
• W2034147064 cites W1503916499 @default.
• W2034147064 cites W1505737561 @default.
• W2034147064 cites W1956426233 @default.
• W2034147064 cites W1963767682 @default.
• W2034147064 cites W1965095016 @default.
• W2034147064 cites W1965286266 @default.
• W2034147064 cites W1967058595 @default.
• W2034147064 cites W1967577586 @default.
• W2034147064 cites W1967823816 @default.
• W2034147064 cites W1971108880 @default.
• W2034147064 cites W1973056215 @default.
• W2034147064 cites W1973615540 @default.
• W2034147064 cites W1974059817 @default.
• W2034147064 cites W1977267085 @default.
• W2034147064 cites W1978959047 @default.
• W2034147064 cites W1979550926 @default.
• W2034147064 cites W1980115442 @default.
• W2034147064 cites W1982797857 @default.
• W2034147064 cites W1984122954 @default.
• W2034147064 cites W1984131083 @default.
• W2034147064 cites W1984766678 @default.
• W2034147064 cites W1989150559 @default.
• W2034147064 cites W1990149510 @default.
• W2034147064 cites W1991462232 @default.
• W2034147064 cites W1994132660 @default.
• W2034147064 cites W1995202691 @default.
• W2034147064 cites W1997938990 @default.
• W2034147064 cites W2004098528 @default.
• W2034147064 cites W2005956580 @default.
• W2034147064 cites W2011476386 @default.
• W2034147064 cites W2015219413 @default.
• W2034147064 cites W2015234786 @default.
• W2034147064 cites W2015329538 @default.
• W2034147064 cites W2018852249 @default.
• W2034147064 cites W2021561354 @default.
• W2034147064 cites W2023048174 @default.
• W2034147064 cites W2025595434 @default.
• W2034147064 cites W2028762358 @default.
• W2034147064 cites W2029319167 @default.
• W2034147064 cites W2030072508 @default.
• W2034147064 cites W2031378173 @default.
• W2034147064 cites W2032355167 @default.
• W2034147064 cites W2032559950 @default.
• W2034147064 cites W2033672635 @default.
• W2034147064 cites W2035282151 @default.
• W2034147064 cites W2035339855 @default.
• W2034147064 cites W2035521907 @default.
• W2034147064 cites W2036024572 @default.
• W2034147064 cites W2036599501 @default.
• W2034147064 cites W2042316019 @default.
• W2034147064 cites W2042825905 @default.
• W2034147064 cites W2044407202 @default.
• W2034147064 cites W2046093999 @default.
• W2034147064 cites W2046885195 @default.
• W2034147064 cites W2048190061 @default.
• W2034147064 cites W2050647292 @default.
• W2034147064 cites W2051532765 @default.
• W2034147064 cites W2052742260 @default.
• W2034147064 cites W2053476949 @default.
• W2034147064 cites W2056785199 @default.
• W2034147064 cites W2057293794 @default.
• W2034147064 cites W2059804089 @default.
• W2034147064 cites W2063198655 @default.
• W2034147064 cites W2064367582 @default.
• W2034147064 cites W2067682626 @default.
• W2034147064 cites W2073298789 @default.
• W2034147064 cites W2073449985 @default.
• W2034147064 cites W2075793841 @default.
• W2034147064 cites W2076159058 @default.
• W2034147064 cites W2076834744 @default.
• W2034147064 cites W2076844276 @default.
• W2034147064 cites W2079304641 @default.
• W2034147064 cites W2080816290 @default.
• W2034147064 cites W2082923159 @default.
• W2034147064 cites W2084121214 @default.
• W2034147064 cites W2084942172 @default.
• W2034147064 cites W2086403707 @default.
• W2034147064 cites W2089522371 @default.
• W2034147064 cites W2089691915 @default.
• W2034147064 cites W2091196473 @default.
• W2034147064 cites W2096321704 @default.
• W2034147064 cites W2098022922 @default.
• W2034147064 cites W2099340107 @default.
• W2034147064 cites W2099763646 @default.
• W2034147064 cites W2100421640 @default.
• W2034147064 cites W2112140556 @default.
• W2034147064 cites W2113281193 @default.
• W2034147064 cites W2114471971 @default.
• W2034147064 cites W2115298392 @default.
• W2034147064 cites W2121396616 @default.

• next