FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034147772> ?p ?o ?g. }

• W2034147772 endingPage "13129" @default.
• W2034147772 startingPage "13124" @default.
• W2034147772 abstract "In rodent sensory neurons, acid-sensing ion channel 3 (ASIC3) has recently emerged as a particularly important sensor of nonadaptive pain associated with tissue acidosis. However, little is known about the human ASIC3 channel, which includes three splice variants differing in their C-terminal domain (hASIC3a, hASIC3b, and hASIC3c). hASIC3a transcripts represent the main mRNAs expressed in both peripheral and central neuronal tissues (dorsal root ganglia [DRG], spinal cord, and brain), where a small proportion of hASIC3c transcripts is also detected. We show that hASIC3 channels (hASIC3a, hASIC3b, or hASIC3c) are able to directly sense extracellular pH changes not only during acidification (up to pH 5.0), but also during alkalization (up to pH 8.0), an original and inducible property yet unknown. When the external pH decreases, hASIC3 display a transient acid mode with brief activation that is relevant to the classical ASIC currents, as previously described. On the other hand, an external pH increase activates a sustained alkaline mode leading to a constitutive activity at resting pH. Both modes are inhibited by the APETx2 toxin, an ASIC3-type channel inhibitor. The alkaline sensitivity of hASIC3 is an intrinsic property of the channel, which is supported by the extracellular loop and involves two arginines (R68 and R83) only present in the human clone. hASIC3 is thus able to sense the extracellular pH in both directions and therefore to dynamically adapt its activity between pH 5.0 and 8.0, a property likely to participate in the fine tuning of neuronal membrane potential and to neuron sensitization in various pH environments." @default.
• W2034147772 created "2016-06-24" @default.
• W2034147772 creator A5006645417 @default.
• W2034147772 creator A5031109136 @default.
• W2034147772 creator A5046261177 @default.
• W2034147772 creator A5051664646 @default.
• W2034147772 creator A5052368029 @default.
• W2034147772 creator A5059870278 @default.
• W2034147772 creator A5060304637 @default.
• W2034147772 date "2012-07-24" @default.
• W2034147772 modified "2023-10-16" @default.
• W2034147772 title "Human ASIC3 channel dynamically adapts its activity to sense the extracellular pH in both acidic and alkaline directions" @default.
• W2034147772 cites W1528778201 @default.
• W2034147772 cites W1827209814 @default.
• W2034147772 cites W189880865 @default.
• W2034147772 cites W1917723421 @default.
• W2034147772 cites W1965695350 @default.
• W2034147772 cites W1967502463 @default.
• W2034147772 cites W1967863888 @default.
• W2034147772 cites W1970227170 @default.
• W2034147772 cites W1974642350 @default.
• W2034147772 cites W1974801463 @default.
• W2034147772 cites W1987211464 @default.
• W2034147772 cites W1989289789 @default.
• W2034147772 cites W1990681783 @default.
• W2034147772 cites W1991687695 @default.
• W2034147772 cites W2003077765 @default.
• W2034147772 cites W2006294085 @default.
• W2034147772 cites W2009199141 @default.
• W2034147772 cites W2009495224 @default.
• W2034147772 cites W2013711061 @default.
• W2034147772 cites W2019839505 @default.
• W2034147772 cites W2020170548 @default.
• W2034147772 cites W2026989559 @default.
• W2034147772 cites W2028297619 @default.
• W2034147772 cites W2034194515 @default.
• W2034147772 cites W2038683056 @default.
• W2034147772 cites W2043501690 @default.
• W2034147772 cites W2043873737 @default.
• W2034147772 cites W2047283239 @default.
• W2034147772 cites W2078267728 @default.
• W2034147772 cites W2079435575 @default.
• W2034147772 cites W2080762354 @default.
• W2034147772 cites W2091648696 @default.
• W2034147772 cites W2104984002 @default.
• W2034147772 cites W2107988902 @default.
• W2034147772 cites W2108367699 @default.
• W2034147772 cites W2126409480 @default.
• W2034147772 cites W2137678794 @default.
• W2034147772 cites W2160262877 @default.
• W2034147772 cites W2170521339 @default.
• W2034147772 cites W4238017164 @default.
• W2034147772 cites W4238970075 @default.
• W2034147772 doi "https://doi.org/10.1073/pnas.1120350109" @default.
• W2034147772 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3420194" @default.
• W2034147772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22829666" @default.
• W2034147772 hasPublicationYear "2012" @default.
• W2034147772 type Work @default.
• W2034147772 sameAs 2034147772 @default.
• W2034147772 citedByCount "71" @default.
• W2034147772 countsByYear W20341477722013 @default.
• W2034147772 countsByYear W20341477722014 @default.
• W2034147772 countsByYear W20341477722015 @default.
• W2034147772 countsByYear W20341477722016 @default.
• W2034147772 countsByYear W20341477722017 @default.
• W2034147772 countsByYear W20341477722018 @default.
• W2034147772 countsByYear W20341477722019 @default.
• W2034147772 countsByYear W20341477722020 @default.
• W2034147772 countsByYear W20341477722021 @default.
• W2034147772 countsByYear W20341477722022 @default.
• W2034147772 countsByYear W20341477722023 @default.
• W2034147772 crossrefType "journal-article" @default.
• W2034147772 hasAuthorship W2034147772A5006645417 @default.
• W2034147772 hasAuthorship W2034147772A5031109136 @default.
• W2034147772 hasAuthorship W2034147772A5046261177 @default.
• W2034147772 hasAuthorship W2034147772A5051664646 @default.
• W2034147772 hasAuthorship W2034147772A5052368029 @default.
• W2034147772 hasAuthorship W2034147772A5059870278 @default.
• W2034147772 hasAuthorship W2034147772A5060304637 @default.
• W2034147772 hasBestOaLocation W20341477721 @default.
• W2034147772 hasConcept C12554922 @default.
• W2034147772 hasConcept C134018914 @default.
• W2034147772 hasConcept C143928317 @default.
• W2034147772 hasConcept C169760540 @default.
• W2034147772 hasConcept C170493617 @default.
• W2034147772 hasConcept C185592680 @default.
• W2034147772 hasConcept C2778553927 @default.
• W2034147772 hasConcept C28406088 @default.
• W2034147772 hasConcept C50254741 @default.
• W2034147772 hasConcept C55493867 @default.
• W2034147772 hasConcept C86803240 @default.
• W2034147772 hasConcept C95444343 @default.
• W2034147772 hasConceptScore W2034147772C12554922 @default.
• W2034147772 hasConceptScore W2034147772C134018914 @default.
• W2034147772 hasConceptScore W2034147772C143928317 @default.
• W2034147772 hasConceptScore W2034147772C169760540 @default.
• W2034147772 hasConceptScore W2034147772C170493617 @default.
• W2034147772 hasConceptScore W2034147772C185592680 @default.

• next