Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034147908> ?p ?o ?g. }
- W2034147908 endingPage "297" @default.
- W2034147908 startingPage "289" @default.
- W2034147908 abstract "Recent preclinical and clinical studies have indicated a possible involvement of the genes encoding for the GABA(A) receptor subunits alpha6, beta2, alpha1 and gamma2 in the genetic susceptibility to alcohol abuse. We have recently found an (R) to (Q) mutation in codon 100 of the alpha6 GABA(A) subunit, that segregated in a rat line selectively bred for its voluntary ethanol aversion, Sardinian alcohol nonpreferring (sNP), but not in their Sardinian alcohol preferring (sP) counterpart, selected for its ethanol preference. In the present study the molecular composition of other GABA(A) subunits (beta2, alpha1 and gamma2) were analyzed in order to further investigate the involvement of the GABA(A) receptors in the genetic predisposition to voluntary alcohol intake. Automated sequencing analysis indicated the presence of six new silent substitutions (289 T-->C in the beta2 gene; 115 G-->A in the alpha1 gene; 157 G-->A, 174 C-->T, 347 A-->G and 385 A-->T in the gamma2 gene), in sNP but not in sP rats. These polymorphisms were linked to the alpha6 R100Q mutation previously described in sNP rats. The strict association between the alpha6 point mutation and the new polymorphisms found in the beta2, alpha1 and gamma2 genes, demonstrate that such genes belong to the same cluster and are inherited together in the rat. These results sustain the synteny for these clusters between the rodent and human genomes, and suggest that mutated GABA(A) beta2, alpha6, alpha1 and gamma2 subunit genes might contribute to the expression of an ethanol nonpreferring phenotype in a rat line that voluntarily avoids alcoholic solutions." @default.
- W2034147908 created "2016-06-24" @default.
- W2034147908 creator A5014569398 @default.
- W2034147908 creator A5024422484 @default.
- W2034147908 creator A5033846778 @default.
- W2034147908 creator A5042203237 @default.
- W2034147908 creator A5043265958 @default.
- W2034147908 creator A5054088852 @default.
- W2034147908 creator A5089727549 @default.
- W2034147908 creator A5090478044 @default.
- W2034147908 date "2003-02-01" @default.
- W2034147908 modified "2023-09-27" @default.
- W2034147908 title "Molecular characterization of new polymorphisms at the β2, α1, γ2 GABAA receptor subunit genes associated to a rat nonpreferring ethanol phenotype" @default.
- W2034147908 cites W1501337774 @default.
- W2034147908 cites W1570185216 @default.
- W2034147908 cites W1937687163 @default.
- W2034147908 cites W1966581620 @default.
- W2034147908 cites W1970700469 @default.
- W2034147908 cites W1971170321 @default.
- W2034147908 cites W1980844720 @default.
- W2034147908 cites W1982710716 @default.
- W2034147908 cites W1983967908 @default.
- W2034147908 cites W1985042201 @default.
- W2034147908 cites W1998624786 @default.
- W2034147908 cites W1999485170 @default.
- W2034147908 cites W2000650137 @default.
- W2034147908 cites W2001032174 @default.
- W2034147908 cites W2003786364 @default.
- W2034147908 cites W2011218093 @default.
- W2034147908 cites W2014742554 @default.
- W2034147908 cites W2021656295 @default.
- W2034147908 cites W2025810192 @default.
- W2034147908 cites W2029013359 @default.
- W2034147908 cites W2035974852 @default.
- W2034147908 cites W2039303909 @default.
- W2034147908 cites W2049948523 @default.
- W2034147908 cites W2057415531 @default.
- W2034147908 cites W2057457677 @default.
- W2034147908 cites W2059208153 @default.
- W2034147908 cites W2060586131 @default.
- W2034147908 cites W2064063117 @default.
- W2034147908 cites W2067601118 @default.
- W2034147908 cites W2092587709 @default.
- W2034147908 cites W2093117551 @default.
- W2034147908 cites W2095220912 @default.
- W2034147908 cites W2108651940 @default.
- W2034147908 cites W2121132472 @default.
- W2034147908 cites W2123745500 @default.
- W2034147908 cites W2125188380 @default.
- W2034147908 cites W2125669464 @default.
- W2034147908 cites W2134812217 @default.
- W2034147908 cites W2162113743 @default.
- W2034147908 cites W2162666247 @default.
- W2034147908 cites W2162925069 @default.
- W2034147908 cites W2181518245 @default.
- W2034147908 cites W2277679086 @default.
- W2034147908 cites W2315535280 @default.
- W2034147908 cites W2331395765 @default.
- W2034147908 cites W2413732288 @default.
- W2034147908 cites W2444399187 @default.
- W2034147908 doi "https://doi.org/10.1016/s0169-328x(02)00660-5" @default.
- W2034147908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12591165" @default.
- W2034147908 hasPublicationYear "2003" @default.
- W2034147908 type Work @default.
- W2034147908 sameAs 2034147908 @default.
- W2034147908 citedByCount "12" @default.
- W2034147908 countsByYear W20341479082016 @default.
- W2034147908 countsByYear W20341479082021 @default.
- W2034147908 crossrefType "journal-article" @default.
- W2034147908 hasAuthorship W2034147908A5014569398 @default.
- W2034147908 hasAuthorship W2034147908A5024422484 @default.
- W2034147908 hasAuthorship W2034147908A5033846778 @default.
- W2034147908 hasAuthorship W2034147908A5042203237 @default.
- W2034147908 hasAuthorship W2034147908A5043265958 @default.
- W2034147908 hasAuthorship W2034147908A5054088852 @default.
- W2034147908 hasAuthorship W2034147908A5089727549 @default.
- W2034147908 hasAuthorship W2034147908A5090478044 @default.
- W2034147908 hasConcept C104292427 @default.
- W2034147908 hasConcept C104317684 @default.
- W2034147908 hasConcept C127716648 @default.
- W2034147908 hasConcept C501734568 @default.
- W2034147908 hasConcept C54355233 @default.
- W2034147908 hasConcept C86803240 @default.
- W2034147908 hasConceptScore W2034147908C104292427 @default.
- W2034147908 hasConceptScore W2034147908C104317684 @default.
- W2034147908 hasConceptScore W2034147908C127716648 @default.
- W2034147908 hasConceptScore W2034147908C501734568 @default.
- W2034147908 hasConceptScore W2034147908C54355233 @default.
- W2034147908 hasConceptScore W2034147908C86803240 @default.
- W2034147908 hasIssue "2" @default.
- W2034147908 hasLocation W20341479081 @default.
- W2034147908 hasLocation W20341479082 @default.
- W2034147908 hasOpenAccess W2034147908 @default.
- W2034147908 hasPrimaryLocation W20341479081 @default.
- W2034147908 hasRelatedWork W138964897 @default.
- W2034147908 hasRelatedWork W1530402712 @default.
- W2034147908 hasRelatedWork W1946787458 @default.
- W2034147908 hasRelatedWork W2104622833 @default.