FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034148500> ?p ?o ?g. }

• W2034148500 endingPage "S379" @default.
• W2034148500 startingPage "S374" @default.
• W2034148500 abstract "There is a pressing need for new and more efficient boron delivery agents to tumor cells for use in boron neutron capture therapy (BNCT). A class of boronated unnatural cyclic amino acids has demonstrated a remarkable selectivity toward tumors in animal and cell culture models, far superior to currently used agents in clinical BNCT. One of these amino acids, 1-amino-3-boronocyclopentanecarboxylic acid (ABCPC), has shown a tumor to blood ratio of 8 and a tumor to normal brain ratio of nearly 21 in a melanoma bearing mouse model. This work represents further biological characterization of this compound for tumor targeting in an EMT6 murine mammary carcinoma mouse model and a T98G human glioblastoma cell line. Female BALB/c mice bearing EMT6 tumors were injected with the fructose complex form of racemic mixtures of cis and trans isomers of ABCPC in identical concentrations. Boron concentrations were measured in the tumor, blood, brain, skin, and liver tissues at 1, 3, and 5 h post-injection. These observations revealed a remarkable difference in racemic mixtures of cis and trans isomers in tumor targeting by boron. This implies that further separation of the L and D forms of this compound may enhance tumor targeting to an even higher degree than that provided by the racemic mixtures. Since the uptake measurements were made in homogenized tumor and normal tissues, little is known about the subcellular location of the boron arising from the various isomeric forms of the amino acid. To study subcellular delivery of boron from ABCPC in T98G human glioblastoma cells, we employed secondary ion mass spectrometry (SIMS) based technique of ion microscopy, which is capable of quantitatively imaging isotopic (elemental) gradients in cells and tissues at 500 nm spatial resolution. The T98G cells were exposed to the nutrient medium containing 100 ppm boron equivalent of a mixture of both L and D isomers of ABCPC in the form of a fructose complex for 1 h. Following this treatment, the cells were fast frozen, freeze-fractured, and freeze-dried for SIMS analysis. Within an hour of exposure, ABCPC provided partitioning of intracellular to extracellular boron of 3/1. SIMS imaging revealed that boron from ABCPC was distributed throughout the cell, including the nucleus. This level of boron delivery within an hour of exposure is superior to p-boronophenylalanine (BPA) and sodium borocaptate (BSH), which have been previously studied by SIMS in the same cell line. These encouraging observations provide compelling support for further isomeric separations of ABCPC into the D and L forms for enhanced tumor targeting and continued testing of these compounds as new boron carriers in BNCT." @default.
• W2034148500 created "2016-06-24" @default.
• W2034148500 creator A5011176439 @default.
• W2034148500 creator A5055649265 @default.
• W2034148500 creator A5075458707 @default.
• W2034148500 creator A5082481721 @default.
• W2034148500 date "2009-07-01" @default.
• W2034148500 modified "2023-10-09" @default.
• W2034148500 title "Biological evaluation of boronated unnatural amino acids as new boron carriers" @default.
• W2034148500 cites W1905286104 @default.
• W2034148500 cites W1965838160 @default.
• W2034148500 cites W1968803624 @default.
• W2034148500 cites W1970216633 @default.
• W2034148500 cites W1974673024 @default.
• W2034148500 cites W1975258721 @default.
• W2034148500 cites W1981205626 @default.
• W2034148500 cites W1983609602 @default.
• W2034148500 cites W1986752336 @default.
• W2034148500 cites W1991142673 @default.
• W2034148500 cites W1994819207 @default.
• W2034148500 cites W2032925210 @default.
• W2034148500 cites W2033992132 @default.
• W2034148500 cites W2036964732 @default.
• W2034148500 cites W2042492547 @default.
• W2034148500 cites W2044202321 @default.
• W2034148500 cites W2045218004 @default.
• W2034148500 cites W2045255657 @default.
• W2034148500 cites W2051607819 @default.
• W2034148500 cites W2067043175 @default.
• W2034148500 cites W2068572063 @default.
• W2034148500 cites W2145030327 @default.
• W2034148500 cites W2166455547 @default.
• W2034148500 cites W2172390328 @default.
• W2034148500 cites W2413084314 @default.
• W2034148500 cites W2951438911 @default.
• W2034148500 cites W94143881 @default.
• W2034148500 doi "https://doi.org/10.1016/j.apradiso.2009.03.104" @default.
• W2034148500 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2861333" @default.
• W2034148500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19398346" @default.
• W2034148500 hasPublicationYear "2009" @default.
• W2034148500 type Work @default.
• W2034148500 sameAs 2034148500 @default.
• W2034148500 citedByCount "32" @default.
• W2034148500 countsByYear W20341485002012 @default.
• W2034148500 countsByYear W20341485002013 @default.
• W2034148500 countsByYear W20341485002014 @default.
• W2034148500 countsByYear W20341485002015 @default.
• W2034148500 countsByYear W20341485002018 @default.
• W2034148500 countsByYear W20341485002020 @default.
• W2034148500 countsByYear W20341485002021 @default.
• W2034148500 countsByYear W20341485002022 @default.
• W2034148500 countsByYear W20341485002023 @default.
• W2034148500 crossrefType "journal-article" @default.
• W2034148500 hasAuthorship W2034148500A5011176439 @default.
• W2034148500 hasAuthorship W2034148500A5055649265 @default.
• W2034148500 hasAuthorship W2034148500A5075458707 @default.
• W2034148500 hasAuthorship W2034148500A5082481721 @default.
• W2034148500 hasBestOaLocation W20341485002 @default.
• W2034148500 hasConcept C118792377 @default.
• W2034148500 hasConcept C1491633281 @default.
• W2034148500 hasConcept C161790260 @default.
• W2034148500 hasConcept C178790620 @default.
• W2034148500 hasConcept C185592680 @default.
• W2034148500 hasConcept C3020616263 @default.
• W2034148500 hasConcept C501308230 @default.
• W2034148500 hasConcept C502942594 @default.
• W2034148500 hasConcept C515207424 @default.
• W2034148500 hasConcept C54355233 @default.
• W2034148500 hasConcept C55493867 @default.
• W2034148500 hasConcept C71240020 @default.
• W2034148500 hasConcept C81885089 @default.
• W2034148500 hasConcept C86803240 @default.
• W2034148500 hasConceptScore W2034148500C118792377 @default.
• W2034148500 hasConceptScore W2034148500C1491633281 @default.
• W2034148500 hasConceptScore W2034148500C161790260 @default.
• W2034148500 hasConceptScore W2034148500C178790620 @default.
• W2034148500 hasConceptScore W2034148500C185592680 @default.
• W2034148500 hasConceptScore W2034148500C3020616263 @default.
• W2034148500 hasConceptScore W2034148500C501308230 @default.
• W2034148500 hasConceptScore W2034148500C502942594 @default.
• W2034148500 hasConceptScore W2034148500C515207424 @default.
• W2034148500 hasConceptScore W2034148500C54355233 @default.
• W2034148500 hasConceptScore W2034148500C55493867 @default.
• W2034148500 hasConceptScore W2034148500C71240020 @default.
• W2034148500 hasConceptScore W2034148500C81885089 @default.
• W2034148500 hasConceptScore W2034148500C86803240 @default.
• W2034148500 hasIssue "7-8" @default.
• W2034148500 hasLocation W20341485001 @default.
• W2034148500 hasLocation W20341485002 @default.
• W2034148500 hasLocation W20341485003 @default.
• W2034148500 hasLocation W20341485004 @default.
• W2034148500 hasOpenAccess W2034148500 @default.
• W2034148500 hasPrimaryLocation W20341485001 @default.
• W2034148500 hasRelatedWork W1985467192 @default.
• W2034148500 hasRelatedWork W2074571151 @default.
• W2034148500 hasRelatedWork W2114451818 @default.
• W2034148500 hasRelatedWork W2154505035 @default.
• W2034148500 hasRelatedWork W2282716039 @default.

• next