Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034148546> ?p ?o ?g. }
- W2034148546 abstract "Significance Our candidate HIV vaccine, a single-chain gp120-CD4 chimera, elicits protection against acquisition of simian-human immunodeficiency virus (SHIV)/simian immunodeficiency virus (SIV) in rhesus macaques. Antibody-dependent cellular cytotoxicity was an inverse correlate of infection risk. However, it is attenuated when antigen-specific T-cell responses exceed a threshold, presumably due to the generation of CD4+ CCR5+ T cells, the preferred cellular targets of SHIV/SIV. Multiple studies strongly suggest that HIV/SIV-specific T-cell responses are a double-edged sword. On one hand, they are required for T-cell help in the protective antibody response. On the other hand, they appear to mitigate protection by creating new targets for viral replication. Determining the balance between protective antibody responses and attenuating T-cell responses is a key challenge confronting HIV vaccine development." @default.
- W2034148546 created "2016-06-24" @default.
- W2034148546 creator A5004036928 @default.
- W2034148546 creator A5006749029 @default.
- W2034148546 creator A5007240363 @default.
- W2034148546 creator A5010755138 @default.
- W2034148546 creator A5019446644 @default.
- W2034148546 creator A5030545878 @default.
- W2034148546 creator A5031256695 @default.
- W2034148546 creator A5031912842 @default.
- W2034148546 creator A5037640832 @default.
- W2034148546 creator A5038828313 @default.
- W2034148546 creator A5040770925 @default.
- W2034148546 creator A5045766587 @default.
- W2034148546 creator A5050134236 @default.
- W2034148546 creator A5054579074 @default.
- W2034148546 creator A5055963852 @default.
- W2034148546 creator A5056602559 @default.
- W2034148546 creator A5060829019 @default.
- W2034148546 creator A5066261446 @default.
- W2034148546 creator A5066788024 @default.
- W2034148546 creator A5069687616 @default.
- W2034148546 creator A5074212929 @default.
- W2034148546 creator A5082750234 @default.
- W2034148546 date "2015-02-13" @default.
- W2034148546 modified "2023-10-10" @default.
- W2034148546 title "Balance of cellular and humoral immunity determines the level of protection by HIV vaccines in rhesus macaque models of HIV infection" @default.
- W2034148546 cites W1529373421 @default.
- W2034148546 cites W1838210676 @default.
- W2034148546 cites W1854844842 @default.
- W2034148546 cites W1924088703 @default.
- W2034148546 cites W1965175217 @default.
- W2034148546 cites W1965778285 @default.
- W2034148546 cites W1967684158 @default.
- W2034148546 cites W1970173407 @default.
- W2034148546 cites W1975945730 @default.
- W2034148546 cites W1983108992 @default.
- W2034148546 cites W1991546715 @default.
- W2034148546 cites W2003517691 @default.
- W2034148546 cites W2003721378 @default.
- W2034148546 cites W2005000140 @default.
- W2034148546 cites W2005916015 @default.
- W2034148546 cites W2009043731 @default.
- W2034148546 cites W2015404088 @default.
- W2034148546 cites W2017871373 @default.
- W2034148546 cites W2019405644 @default.
- W2034148546 cites W2020100193 @default.
- W2034148546 cites W2020355483 @default.
- W2034148546 cites W2020559014 @default.
- W2034148546 cites W2021760008 @default.
- W2034148546 cites W2024608724 @default.
- W2034148546 cites W2024923044 @default.
- W2034148546 cites W2029157479 @default.
- W2034148546 cites W2029804942 @default.
- W2034148546 cites W2031131336 @default.
- W2034148546 cites W2036741092 @default.
- W2034148546 cites W2040287637 @default.
- W2034148546 cites W2042308547 @default.
- W2034148546 cites W2043642585 @default.
- W2034148546 cites W2043775195 @default.
- W2034148546 cites W2046102446 @default.
- W2034148546 cites W2051926684 @default.
- W2034148546 cites W2055438044 @default.
- W2034148546 cites W2057354009 @default.
- W2034148546 cites W2059597702 @default.
- W2034148546 cites W2062632013 @default.
- W2034148546 cites W2063075897 @default.
- W2034148546 cites W2063121477 @default.
- W2034148546 cites W2063809659 @default.
- W2034148546 cites W2065679398 @default.
- W2034148546 cites W2072553081 @default.
- W2034148546 cites W2074009425 @default.
- W2034148546 cites W2075059757 @default.
- W2034148546 cites W2075737514 @default.
- W2034148546 cites W2084826888 @default.
- W2034148546 cites W2085165735 @default.
- W2034148546 cites W2085988761 @default.
- W2034148546 cites W2098657635 @default.
- W2034148546 cites W2110714233 @default.
- W2034148546 cites W2113822425 @default.
- W2034148546 cites W2117522423 @default.
- W2034148546 cites W2122210861 @default.
- W2034148546 cites W2122531531 @default.
- W2034148546 cites W2122985048 @default.
- W2034148546 cites W2128461524 @default.
- W2034148546 cites W2130651219 @default.
- W2034148546 cites W2131896393 @default.
- W2034148546 cites W2138209294 @default.
- W2034148546 cites W2139235922 @default.
- W2034148546 cites W2141866540 @default.
- W2034148546 cites W2143421242 @default.
- W2034148546 cites W2148111380 @default.
- W2034148546 cites W2150249219 @default.
- W2034148546 cites W2153323679 @default.
- W2034148546 cites W2158154269 @default.
- W2034148546 cites W2158498221 @default.
- W2034148546 cites W2159825993 @default.
- W2034148546 cites W2160787138 @default.
- W2034148546 cites W2161243054 @default.
- W2034148546 cites W2168952458 @default.