Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034148756> ?p ?o ?g. }
- W2034148756 endingPage "289" @default.
- W2034148756 startingPage "281" @default.
- W2034148756 abstract "Objectives: Lithium, valproic acid (VPA) and carbamazepine (CBZ) are commonly used mood stabilizers, but their therapeutic mechanism is unclear. These drugs all cause the same morphological effects on postnatal rat neuronal dorsal root ganglia (DRG) growth cones via an inositol-reversible mechanism. However, due to limitations in earlier analysis, the effects of combining drugs, drug specificity and inositol stereoisomer specificity are unknown. We devised an improved analytical method to address these issues. Methods: Dorsal root ganglia explants were cultured individually and incubated with combinations of psychotropic drugs and inositol stereoisomers. We recorded axonal growth cone morphology and calculated growth cone area per a modified method described by Williams et al. (Nature 2002; 417: 292–295). Statistically significant changes in area were calculated using non-parametric statistical testing. Results: (i) Lithium and VPA showed an additive effect on growth cone spreading. (ii) Among eight additional psychotropic drugs to those previously tested, only imipramine and chlorpromazine altered DRG growth cone morphology. As this effect was not reversed by myo-inositol, it arises from a different mechanism to the mood stabilizers lithium, VPA and CBZ. (iii) Myo-inositol, but not scyllo- or epi-inositol, causes a significant reversal of the lithium effect on the growth cones spreading, consistent with the inositol depletion hypothesis. Conclusions: These results show that lithium, VPA and CBZ are unique in causing altered neuronal morphology via myo-inositol depletion." @default.
- W2034148756 created "2016-06-24" @default.
- W2034148756 creator A5005716926 @default.
- W2034148756 creator A5060342234 @default.
- W2034148756 creator A5061874089 @default.
- W2034148756 creator A5072343139 @default.
- W2034148756 creator A5087417185 @default.
- W2034148756 date "2007-05-01" @default.
- W2034148756 modified "2023-09-23" @default.
- W2034148756 title "Specificity of mood stabilizer action on neuronal growth cones" @default.
- W2034148756 cites W1536031381 @default.
- W2034148756 cites W1552654146 @default.
- W2034148756 cites W1557552045 @default.
- W2034148756 cites W1927894522 @default.
- W2034148756 cites W1952564245 @default.
- W2034148756 cites W1970891546 @default.
- W2034148756 cites W1984935769 @default.
- W2034148756 cites W1993813160 @default.
- W2034148756 cites W1995444530 @default.
- W2034148756 cites W2023772121 @default.
- W2034148756 cites W2024315113 @default.
- W2034148756 cites W2029078015 @default.
- W2034148756 cites W2046539696 @default.
- W2034148756 cites W2049689700 @default.
- W2034148756 cites W2051788298 @default.
- W2034148756 cites W2053376403 @default.
- W2034148756 cites W2054851762 @default.
- W2034148756 cites W2057647371 @default.
- W2034148756 cites W2064560881 @default.
- W2034148756 cites W2070550885 @default.
- W2034148756 cites W2074085337 @default.
- W2034148756 cites W2075372825 @default.
- W2034148756 cites W2075780278 @default.
- W2034148756 cites W2076403167 @default.
- W2034148756 cites W2081049470 @default.
- W2034148756 cites W2085968319 @default.
- W2034148756 cites W2090874481 @default.
- W2034148756 cites W2094063881 @default.
- W2034148756 cites W2098249941 @default.
- W2034148756 cites W2105315411 @default.
- W2034148756 cites W2106820442 @default.
- W2034148756 cites W2113455293 @default.
- W2034148756 cites W2118822326 @default.
- W2034148756 cites W2125477115 @default.
- W2034148756 cites W2134773980 @default.
- W2034148756 cites W2137072938 @default.
- W2034148756 cites W2147643260 @default.
- W2034148756 cites W2161831258 @default.
- W2034148756 cites W2166260758 @default.
- W2034148756 doi "https://doi.org/10.1111/j.1399-5618.2007.00400.x" @default.
- W2034148756 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17430303" @default.
- W2034148756 hasPublicationYear "2007" @default.
- W2034148756 type Work @default.
- W2034148756 sameAs 2034148756 @default.
- W2034148756 citedByCount "22" @default.
- W2034148756 countsByYear W20341487562012 @default.
- W2034148756 countsByYear W20341487562013 @default.
- W2034148756 countsByYear W20341487562014 @default.
- W2034148756 countsByYear W20341487562015 @default.
- W2034148756 countsByYear W20341487562017 @default.
- W2034148756 countsByYear W20341487562020 @default.
- W2034148756 countsByYear W20341487562021 @default.
- W2034148756 countsByYear W20341487562022 @default.
- W2034148756 crossrefType "journal-article" @default.
- W2034148756 hasAuthorship W2034148756A5005716926 @default.
- W2034148756 hasAuthorship W2034148756A5060342234 @default.
- W2034148756 hasAuthorship W2034148756A5061874089 @default.
- W2034148756 hasAuthorship W2034148756A5072343139 @default.
- W2034148756 hasAuthorship W2034148756A5087417185 @default.
- W2034148756 hasConcept C134018914 @default.
- W2034148756 hasConcept C142724271 @default.
- W2034148756 hasConcept C169760540 @default.
- W2034148756 hasConcept C170493617 @default.
- W2034148756 hasConcept C185592680 @default.
- W2034148756 hasConcept C202751555 @default.
- W2034148756 hasConcept C204787440 @default.
- W2034148756 hasConcept C2776120743 @default.
- W2034148756 hasConcept C2776174506 @default.
- W2034148756 hasConcept C2777427919 @default.
- W2034148756 hasConcept C2778186239 @default.
- W2034148756 hasConcept C2778541603 @default.
- W2034148756 hasConcept C2779145073 @default.
- W2034148756 hasConcept C2779253243 @default.
- W2034148756 hasConcept C2780550438 @default.
- W2034148756 hasConcept C55493867 @default.
- W2034148756 hasConcept C71924100 @default.
- W2034148756 hasConcept C86803240 @default.
- W2034148756 hasConcept C98274493 @default.
- W2034148756 hasConceptScore W2034148756C134018914 @default.
- W2034148756 hasConceptScore W2034148756C142724271 @default.
- W2034148756 hasConceptScore W2034148756C169760540 @default.
- W2034148756 hasConceptScore W2034148756C170493617 @default.
- W2034148756 hasConceptScore W2034148756C185592680 @default.
- W2034148756 hasConceptScore W2034148756C202751555 @default.
- W2034148756 hasConceptScore W2034148756C204787440 @default.
- W2034148756 hasConceptScore W2034148756C2776120743 @default.
- W2034148756 hasConceptScore W2034148756C2776174506 @default.
- W2034148756 hasConceptScore W2034148756C2777427919 @default.