Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034148884> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2034148884 endingPage "846" @default.
- W2034148884 startingPage "840" @default.
- W2034148884 abstract "To evaluate whether maternal illness following picornavirus infection during pregnancy adversely affects placental and fetal health, mice were inoculated with the GDVII strain of Theiler's murine encephalomyelitis virus or control cell lysate during days 4-7 of gestation. Gross appearance, histopathology and viral culture, and in situ hybridization positivity of placentae and fetuses from ill GDVII-infected, healthy GDVII-infected and control mice were compared. Twenty of 34 (59 per cent) GDVII-infected dams became clinically ill. More placenta-fetus pairs from ill mice were grossly abnormal (68 per cent) than from well GDVII-infected (51 per cent;P< 0.01) or control mice (9 per cent;P< 0.001). Virus was detected by in situ hybridization in 73 per cent of placentae and 29 per cent of fetuses from sick GDVII-infected dams, and in 85 per cent of placentae and 19 per cent of fetuses from healthy GDVII-infected mice (differences not significant). Histological abnormalities consisting of necrosis or an increase in hyaline tissue in the vascular labyrinth layer were similarly frequent in placentae from ill and well GDVII-infected mice (58 per cent versus 67 per cent, P=0.5). Viral RNA, inflammation and necrosis were evident in the heart, great vessels, brain and spinal cord of GDVII-infected fetuses. Infection with GDVII in early pregnancy produces a high rate of gross placental and fetal abnormalities. The rate of gross abnormalities exceeds the incidence of fetal infection and more closely parallels the rates of infection and histopathology in the placenta, suggesting that much of the damage to placenta-fetus pairs is a consequence of placental infection. In addition, the occurrence of viral-induced maternal illness is associated with additive risk to placental and fetal health not explained by an increased rate of placental or fetal infection." @default.
- W2034148884 created "2016-06-24" @default.
- W2034148884 creator A5047341084 @default.
- W2034148884 creator A5056374294 @default.
- W2034148884 date "2000-11-01" @default.
- W2034148884 modified "2023-09-24" @default.
- W2034148884 title "Picornavirus Infection in Early Murine Gestation: Significance of Maternal Illness" @default.
- W2034148884 cites W1985954267 @default.
- W2034148884 cites W2001336050 @default.
- W2034148884 cites W2023167265 @default.
- W2034148884 cites W2105091801 @default.
- W2034148884 cites W2122841120 @default.
- W2034148884 cites W2161879579 @default.
- W2034148884 cites W2171030657 @default.
- W2034148884 cites W2257719725 @default.
- W2034148884 cites W2333920549 @default.
- W2034148884 cites W2568596784 @default.
- W2034148884 cites W574546459 @default.
- W2034148884 cites W587298658 @default.
- W2034148884 doi "https://doi.org/10.1053/plac.2000.0577" @default.
- W2034148884 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11095934" @default.
- W2034148884 hasPublicationYear "2000" @default.
- W2034148884 type Work @default.
- W2034148884 sameAs 2034148884 @default.
- W2034148884 citedByCount "6" @default.
- W2034148884 countsByYear W20341488842014 @default.
- W2034148884 countsByYear W20341488842015 @default.
- W2034148884 countsByYear W20341488842016 @default.
- W2034148884 crossrefType "journal-article" @default.
- W2034148884 hasAuthorship W2034148884A5047341084 @default.
- W2034148884 hasAuthorship W2034148884A5056374294 @default.
- W2034148884 hasConcept C142724271 @default.
- W2034148884 hasConcept C16685009 @default.
- W2034148884 hasConcept C172680121 @default.
- W2034148884 hasConcept C2776953305 @default.
- W2034148884 hasConcept C2779234561 @default.
- W2034148884 hasConcept C42407357 @default.
- W2034148884 hasConcept C46973012 @default.
- W2034148884 hasConcept C54355233 @default.
- W2034148884 hasConcept C544855455 @default.
- W2034148884 hasConcept C71924100 @default.
- W2034148884 hasConcept C86803240 @default.
- W2034148884 hasConceptScore W2034148884C142724271 @default.
- W2034148884 hasConceptScore W2034148884C16685009 @default.
- W2034148884 hasConceptScore W2034148884C172680121 @default.
- W2034148884 hasConceptScore W2034148884C2776953305 @default.
- W2034148884 hasConceptScore W2034148884C2779234561 @default.
- W2034148884 hasConceptScore W2034148884C42407357 @default.
- W2034148884 hasConceptScore W2034148884C46973012 @default.
- W2034148884 hasConceptScore W2034148884C54355233 @default.
- W2034148884 hasConceptScore W2034148884C544855455 @default.
- W2034148884 hasConceptScore W2034148884C71924100 @default.
- W2034148884 hasConceptScore W2034148884C86803240 @default.
- W2034148884 hasIssue "8" @default.
- W2034148884 hasLocation W20341488841 @default.
- W2034148884 hasLocation W20341488842 @default.
- W2034148884 hasOpenAccess W2034148884 @default.
- W2034148884 hasPrimaryLocation W20341488841 @default.
- W2034148884 hasRelatedWork W1602265346 @default.
- W2034148884 hasRelatedWork W2056340985 @default.
- W2034148884 hasRelatedWork W2063828562 @default.
- W2034148884 hasRelatedWork W2105380325 @default.
- W2034148884 hasRelatedWork W2130267169 @default.
- W2034148884 hasRelatedWork W2163638983 @default.
- W2034148884 hasRelatedWork W2170714658 @default.
- W2034148884 hasRelatedWork W2316928384 @default.
- W2034148884 hasRelatedWork W2761724259 @default.
- W2034148884 hasRelatedWork W2809225164 @default.
- W2034148884 hasVolume "21" @default.
- W2034148884 isParatext "false" @default.
- W2034148884 isRetracted "false" @default.
- W2034148884 magId "2034148884" @default.
- W2034148884 workType "article" @default.