Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034149728> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2034149728 endingPage "2153" @default.
- W2034149728 startingPage "2149" @default.
- W2034149728 abstract "Glutathione S-transferase activity and levels of glutathione S-transferases-α, -µ and -π were determined in 10 matched pairs of normal liver and liver metastasis from patients with colorectal cancer. For comparison, six matched pairs of colorectal cancer and normal mucosa were analysed. All metastases had a lower glutathione S-transferase activity when compared to the matched normal liver tissue (224 ± 21 versus 900 ± 95 nmol/min.mg protein respectively, P < 0.001). Mean activities in primary tumours and normal colorectal tissue were 176 ± 22 and 150 ± 13 nmol/min.mg protein respectively. When analysed by immunoblot techniques, each metastasis contained less glutathione S-transferase-α than the surrounding normal liver (mean values 33 ± 0.8 versus 21.8 ± 1.8 µg/mg protein respectively, P < 0.001). Glutathione S-transferase α was undetectable in all primary tumours and normal colonic mucosa. Glutathione S-transferase-µ was detected in only two patients with liver metastases and in two patients with primary colorectal cancer. All metastases contained more glutathione S-transferase-π than the surrounding normal liver tissue (3.7 ± 0.5 versus 0.4 ± 0.1 µg/mg protein respectively, P < 0.001). The values in the metastases were very similar to those in the primary colonic tumours (normal mucosa 2.3 ± 0.3 and tumours 3.3 ± 0.7 µg/mg protein). Immunohistochemical investigation of the metastases revealed that glutathione S-transferase-α is not located in the malignant cells, but only in hepatocytes in what macroscopically seemed to be pure metastatic tissue. Staining for glutathione S-transferase-π reveals generally positive tumour cells and, except for the biliary epithelium, only faint staining of the hepatocytes. It is concluded that liver metastases of colorectal carcinomas have very similar glutathione S-transferase enzyme activities and composition as compared with primary tumours." @default.
- W2034149728 created "2016-06-24" @default.
- W2034149728 creator A5020233877 @default.
- W2034149728 creator A5022207213 @default.
- W2034149728 creator A5041675295 @default.
- W2034149728 creator A5051903151 @default.
- W2034149728 creator A5053115428 @default.
- W2034149728 creator A5090096153 @default.
- W2034149728 date "1994-01-01" @default.
- W2034149728 modified "2023-09-25" @default.
- W2034149728 title "Glutathione S-transferases in liver metastases of colorectal cancer. A comparison with normal liver and primary carcinomas" @default.
- W2034149728 doi "https://doi.org/10.1093/carcin/15.10.2149" @default.
- W2034149728 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7955047" @default.
- W2034149728 hasPublicationYear "1994" @default.
- W2034149728 type Work @default.
- W2034149728 sameAs 2034149728 @default.
- W2034149728 citedByCount "18" @default.
- W2034149728 countsByYear W20341497282013 @default.
- W2034149728 countsByYear W20341497282018 @default.
- W2034149728 crossrefType "journal-article" @default.
- W2034149728 hasAuthorship W2034149728A5020233877 @default.
- W2034149728 hasAuthorship W2034149728A5022207213 @default.
- W2034149728 hasAuthorship W2034149728A5041675295 @default.
- W2034149728 hasAuthorship W2034149728A5051903151 @default.
- W2034149728 hasAuthorship W2034149728A5053115428 @default.
- W2034149728 hasAuthorship W2034149728A5090096153 @default.
- W2034149728 hasConcept C121608353 @default.
- W2034149728 hasConcept C126322002 @default.
- W2034149728 hasConcept C142724271 @default.
- W2034149728 hasConcept C181199279 @default.
- W2034149728 hasConcept C204232928 @default.
- W2034149728 hasConcept C2776376580 @default.
- W2034149728 hasConcept C2776907368 @default.
- W2034149728 hasConcept C2779013556 @default.
- W2034149728 hasConcept C526805850 @default.
- W2034149728 hasConcept C538909803 @default.
- W2034149728 hasConcept C55493867 @default.
- W2034149728 hasConcept C71924100 @default.
- W2034149728 hasConcept C86803240 @default.
- W2034149728 hasConceptScore W2034149728C121608353 @default.
- W2034149728 hasConceptScore W2034149728C126322002 @default.
- W2034149728 hasConceptScore W2034149728C142724271 @default.
- W2034149728 hasConceptScore W2034149728C181199279 @default.
- W2034149728 hasConceptScore W2034149728C204232928 @default.
- W2034149728 hasConceptScore W2034149728C2776376580 @default.
- W2034149728 hasConceptScore W2034149728C2776907368 @default.
- W2034149728 hasConceptScore W2034149728C2779013556 @default.
- W2034149728 hasConceptScore W2034149728C526805850 @default.
- W2034149728 hasConceptScore W2034149728C538909803 @default.
- W2034149728 hasConceptScore W2034149728C55493867 @default.
- W2034149728 hasConceptScore W2034149728C71924100 @default.
- W2034149728 hasConceptScore W2034149728C86803240 @default.
- W2034149728 hasIssue "10" @default.
- W2034149728 hasLocation W20341497281 @default.
- W2034149728 hasLocation W20341497282 @default.
- W2034149728 hasOpenAccess W2034149728 @default.
- W2034149728 hasPrimaryLocation W20341497281 @default.
- W2034149728 hasRelatedWork W1812293196 @default.
- W2034149728 hasRelatedWork W1965668597 @default.
- W2034149728 hasRelatedWork W1969486561 @default.
- W2034149728 hasRelatedWork W1970423756 @default.
- W2034149728 hasRelatedWork W1972928594 @default.
- W2034149728 hasRelatedWork W2041788909 @default.
- W2034149728 hasRelatedWork W2067716481 @default.
- W2034149728 hasRelatedWork W2089071106 @default.
- W2034149728 hasRelatedWork W2353465412 @default.
- W2034149728 hasRelatedWork W2404917880 @default.
- W2034149728 hasVolume "15" @default.
- W2034149728 isParatext "false" @default.
- W2034149728 isRetracted "false" @default.
- W2034149728 magId "2034149728" @default.
- W2034149728 workType "article" @default.