Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034150239> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W2034150239 endingPage "249" @default.
- W2034150239 startingPage "239" @default.
- W2034150239 abstract "To clarify the relation between the negative inotropic effects of “calcim-antagonistic” vasodilators and their calcium-antagonistic effects, the effects of nifedipine, verapamil and diltiazem on isolated electrically-driven left atrial preparations of the guinea pig were studied. The ion-specificity of the antagonistic effects was also studied. In normal Tyrode’s solution, all three vasodilators produced a shift to the right of the dose-response curve for calcium, the pA 2 values being 5.90 for nifedipine, 4.88 for verapamil and 4.07 for diltiazem. The maximum rate of rise of action potentials recorded as a measure of the sodium permeability of the membrane was found to be reduced by verapamil and diltiazem, while this rate was unaffected by nifedipine. All three vasodilators suppressed the contractile activities induced in potassium-depolarized atria by isoproterenol and the dose-response curves for calcium were shifted to the right, the pA 2 values being 8.24 for nifedipine, 6.67 for verapamil and 6.57 for diltiazem. In another set of experiments, calcium-dependent action potentials were evoked in the potassium-depolarized atria either by isoproterenol or aminophylline. These action potentials were suppressed by the above three vasodilators at dosage levels comparable to those producing suppression of the isoproterenol-induced contractile response of the depolarized atria." @default.
- W2034150239 created "2016-06-24" @default.
- W2034150239 creator A5004430568 @default.
- W2034150239 date "1977-01-01" @default.
- W2034150239 modified "2023-10-17" @default.
- W2034150239 title "Effects of Calcium-Antagonistic Coronary Vasodilators on Myocardial Contractility and Membrane Potentials" @default.
- W2034150239 doi "https://doi.org/10.1254/jjp.27.239" @default.
- W2034150239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/886659" @default.
- W2034150239 hasPublicationYear "1977" @default.
- W2034150239 type Work @default.
- W2034150239 sameAs 2034150239 @default.
- W2034150239 citedByCount "81" @default.
- W2034150239 countsByYear W20341502392017 @default.
- W2034150239 crossrefType "journal-article" @default.
- W2034150239 hasAuthorship W2034150239A5004430568 @default.
- W2034150239 hasBestOaLocation W20341502391 @default.
- W2034150239 hasConcept C120770815 @default.
- W2034150239 hasConcept C126322002 @default.
- W2034150239 hasConcept C134018914 @default.
- W2034150239 hasConcept C155710745 @default.
- W2034150239 hasConcept C185592680 @default.
- W2034150239 hasConcept C2776741139 @default.
- W2034150239 hasConcept C2777022698 @default.
- W2034150239 hasConcept C2779066535 @default.
- W2034150239 hasConcept C2909076160 @default.
- W2034150239 hasConcept C39133596 @default.
- W2034150239 hasConcept C519063684 @default.
- W2034150239 hasConcept C71924100 @default.
- W2034150239 hasConcept C98274493 @default.
- W2034150239 hasConceptScore W2034150239C120770815 @default.
- W2034150239 hasConceptScore W2034150239C126322002 @default.
- W2034150239 hasConceptScore W2034150239C134018914 @default.
- W2034150239 hasConceptScore W2034150239C155710745 @default.
- W2034150239 hasConceptScore W2034150239C185592680 @default.
- W2034150239 hasConceptScore W2034150239C2776741139 @default.
- W2034150239 hasConceptScore W2034150239C2777022698 @default.
- W2034150239 hasConceptScore W2034150239C2779066535 @default.
- W2034150239 hasConceptScore W2034150239C2909076160 @default.
- W2034150239 hasConceptScore W2034150239C39133596 @default.
- W2034150239 hasConceptScore W2034150239C519063684 @default.
- W2034150239 hasConceptScore W2034150239C71924100 @default.
- W2034150239 hasConceptScore W2034150239C98274493 @default.
- W2034150239 hasIssue "2" @default.
- W2034150239 hasLocation W20341502391 @default.
- W2034150239 hasLocation W20341502392 @default.
- W2034150239 hasOpenAccess W2034150239 @default.
- W2034150239 hasPrimaryLocation W20341502391 @default.
- W2034150239 hasRelatedWork W1981659202 @default.
- W2034150239 hasRelatedWork W2034150239 @default.
- W2034150239 hasRelatedWork W2051413992 @default.
- W2034150239 hasRelatedWork W2058143759 @default.
- W2034150239 hasRelatedWork W2076103635 @default.
- W2034150239 hasRelatedWork W2171101647 @default.
- W2034150239 hasRelatedWork W2256369066 @default.
- W2034150239 hasRelatedWork W2402164523 @default.
- W2034150239 hasRelatedWork W2412014386 @default.
- W2034150239 hasRelatedWork W48789467 @default.
- W2034150239 hasVolume "27" @default.
- W2034150239 isParatext "false" @default.
- W2034150239 isRetracted "false" @default.
- W2034150239 magId "2034150239" @default.
- W2034150239 workType "article" @default.