Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034151554> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2034151554 endingPage "8221" @default.
- W2034151554 startingPage "8212" @default.
- W2034151554 abstract "The objective of this study was to explore the degradation behaviour of saxagliptin (SAX), a dipeptidyl peptidase-4 (DPP-4) inhibitor, under hydrolytic (acidic, alkaline, and neutral), oxidative, photolytic, and thermal stress conditions as per prescribed International Conference on Harmonization (ICH) guidelines. The drug was found to be labile under hydrolytic and oxidative stress conditions, whereas it was stable under photolytic and thermolytic stress conditions. A total of seven degradation products (DPs) were identified, and their chromatographic separation was accomplished on a C18 column (100 × 4.6 mm; 5 μm) using a mobile phase consisting of 10 mM ammonium formate and methanol in a gradient elution mode. All of the stressed samples were subjected to LC-MS, LC-MS/MS, and ESI-Q-TOF-MS/MS analysis. SAX and its DPs were characterized based on elemental composition and isotopic distribution information from full scan mode and fragmentation patterns obtained from MS/MS and HRMS experiments. Structural elucidation of DPs was achieved by comparing their fragmentation patterns with that of SAX. The developed LC method was validated as per ICH guidelines with respect to specificity, linearity, accuracy, precision, and robustness." @default.
- W2034151554 created "2016-06-24" @default.
- W2034151554 creator A5011147962 @default.
- W2034151554 creator A5020946812 @default.
- W2034151554 creator A5037227377 @default.
- W2034151554 creator A5078420585 @default.
- W2034151554 creator A5083871967 @default.
- W2034151554 creator A5087605563 @default.
- W2034151554 date "2014-08-15" @default.
- W2034151554 modified "2023-09-23" @default.
- W2034151554 title "LC-ESI-MS/MS studies on saxagliptin and its forced degradation products" @default.
- W2034151554 cites W1989311034 @default.
- W2034151554 cites W1995567716 @default.
- W2034151554 cites W1999822766 @default.
- W2034151554 cites W2012437459 @default.
- W2034151554 cites W2019393610 @default.
- W2034151554 cites W2021796866 @default.
- W2034151554 cites W2023408735 @default.
- W2034151554 cites W2028876886 @default.
- W2034151554 cites W2087179216 @default.
- W2034151554 cites W2109136798 @default.
- W2034151554 cites W2119353555 @default.
- W2034151554 cites W2169733676 @default.
- W2034151554 doi "https://doi.org/10.1039/c4ay01152j" @default.
- W2034151554 hasPublicationYear "2014" @default.
- W2034151554 type Work @default.
- W2034151554 sameAs 2034151554 @default.
- W2034151554 citedByCount "3" @default.
- W2034151554 countsByYear W20341515542018 @default.
- W2034151554 countsByYear W20341515542023 @default.
- W2034151554 crossrefType "journal-article" @default.
- W2034151554 hasAuthorship W2034151554A5011147962 @default.
- W2034151554 hasAuthorship W2034151554A5020946812 @default.
- W2034151554 hasAuthorship W2034151554A5037227377 @default.
- W2034151554 hasAuthorship W2034151554A5078420585 @default.
- W2034151554 hasAuthorship W2034151554A5083871967 @default.
- W2034151554 hasAuthorship W2034151554A5087605563 @default.
- W2034151554 hasConcept C134018914 @default.
- W2034151554 hasConcept C161790260 @default.
- W2034151554 hasConcept C162356407 @default.
- W2034151554 hasConcept C178790620 @default.
- W2034151554 hasConcept C185592680 @default.
- W2034151554 hasConcept C2775986502 @default.
- W2034151554 hasConcept C2777682752 @default.
- W2034151554 hasConcept C2779284873 @default.
- W2034151554 hasConcept C2779607525 @default.
- W2034151554 hasConcept C2780178953 @default.
- W2034151554 hasConcept C2780282729 @default.
- W2034151554 hasConcept C2780323712 @default.
- W2034151554 hasConcept C43617362 @default.
- W2034151554 hasConcept C555293320 @default.
- W2034151554 hasConcept C71924100 @default.
- W2034151554 hasConcept C94412978 @default.
- W2034151554 hasConceptScore W2034151554C134018914 @default.
- W2034151554 hasConceptScore W2034151554C161790260 @default.
- W2034151554 hasConceptScore W2034151554C162356407 @default.
- W2034151554 hasConceptScore W2034151554C178790620 @default.
- W2034151554 hasConceptScore W2034151554C185592680 @default.
- W2034151554 hasConceptScore W2034151554C2775986502 @default.
- W2034151554 hasConceptScore W2034151554C2777682752 @default.
- W2034151554 hasConceptScore W2034151554C2779284873 @default.
- W2034151554 hasConceptScore W2034151554C2779607525 @default.
- W2034151554 hasConceptScore W2034151554C2780178953 @default.
- W2034151554 hasConceptScore W2034151554C2780282729 @default.
- W2034151554 hasConceptScore W2034151554C2780323712 @default.
- W2034151554 hasConceptScore W2034151554C43617362 @default.
- W2034151554 hasConceptScore W2034151554C555293320 @default.
- W2034151554 hasConceptScore W2034151554C71924100 @default.
- W2034151554 hasConceptScore W2034151554C94412978 @default.
- W2034151554 hasFunder F4320320682 @default.
- W2034151554 hasIssue "20" @default.
- W2034151554 hasLocation W20341515541 @default.
- W2034151554 hasOpenAccess W2034151554 @default.
- W2034151554 hasPrimaryLocation W20341515541 @default.
- W2034151554 hasRelatedWork W1978993209 @default.
- W2034151554 hasRelatedWork W1990710770 @default.
- W2034151554 hasRelatedWork W1999193246 @default.
- W2034151554 hasRelatedWork W2009060800 @default.
- W2034151554 hasRelatedWork W2056570797 @default.
- W2034151554 hasRelatedWork W2082783574 @default.
- W2034151554 hasRelatedWork W2111694973 @default.
- W2034151554 hasRelatedWork W2113036296 @default.
- W2034151554 hasRelatedWork W2767662965 @default.
- W2034151554 hasRelatedWork W3030218436 @default.
- W2034151554 hasVolume "6" @default.
- W2034151554 isParatext "false" @default.
- W2034151554 isRetracted "false" @default.
- W2034151554 magId "2034151554" @default.
- W2034151554 workType "article" @default.