Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034151574> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2034151574 endingPage "426" @default.
- W2034151574 startingPage "418" @default.
- W2034151574 abstract "Autoimmune systemic lupus erythematosus (SLE) nephritis is characterized by the influx of mononuclear inflammatory cell infiltrates within the glomeruli and renal interstitium. To evaluate the possibility that intrarenal T cells result from the expansion of lymphocytes using limited T-cell receptor (TCR) genes, we analyzed the TCR Vbeta gene expression among infiltrating lymphocytes in renal tissue compared with simultaneous peripheral blood lymphocytes of four children with new-onset SLE nephritis. The TCR Vbeta gene expression in peripheral blood T cells from patients with SLE nephritis, when compared with normal controls, showed no preferential expansion or deletion of select Vbeta gene families. In contrast, when paired peripheral blood and renal tissue were analyzed, intrarenal lymphocytes in SLE nephritis demonstrated evidence of expansion of select Vbeta gene families. Sequence analysis of the V(D)J joining regions of the TCRbeta with the expanded families demonstrated a striking oligoclonality. These observations suggest that infiltrating T cells within renal tissue may use TCR Vbeta genes targeted toward nephritogenic antigens." @default.
- W2034151574 created "2016-06-24" @default.
- W2034151574 creator A5002186191 @default.
- W2034151574 creator A5047545190 @default.
- W2034151574 creator A5069864289 @default.
- W2034151574 date "1998-03-01" @default.
- W2034151574 modified "2023-09-30" @default.
- W2034151574 title "SLE nephritis is associated with an oligoclonal expansion of intrarenal T cells" @default.
- W2034151574 doi "https://doi.org/10.1053/ajkd.1998.v31.pm9506678" @default.
- W2034151574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9506678" @default.
- W2034151574 hasPublicationYear "1998" @default.
- W2034151574 type Work @default.
- W2034151574 sameAs 2034151574 @default.
- W2034151574 citedByCount "31" @default.
- W2034151574 countsByYear W20341515742012 @default.
- W2034151574 countsByYear W20341515742015 @default.
- W2034151574 countsByYear W20341515742018 @default.
- W2034151574 countsByYear W20341515742019 @default.
- W2034151574 countsByYear W20341515742020 @default.
- W2034151574 countsByYear W20341515742021 @default.
- W2034151574 countsByYear W20341515742022 @default.
- W2034151574 countsByYear W20341515742023 @default.
- W2034151574 crossrefType "journal-article" @default.
- W2034151574 hasAuthorship W2034151574A5002186191 @default.
- W2034151574 hasAuthorship W2034151574A5047545190 @default.
- W2034151574 hasAuthorship W2034151574A5069864289 @default.
- W2034151574 hasConcept C104317684 @default.
- W2034151574 hasConcept C137061746 @default.
- W2034151574 hasConcept C142724271 @default.
- W2034151574 hasConcept C147483822 @default.
- W2034151574 hasConcept C19317047 @default.
- W2034151574 hasConcept C202751555 @default.
- W2034151574 hasConcept C203014093 @default.
- W2034151574 hasConcept C2776090121 @default.
- W2034151574 hasConcept C2777058396 @default.
- W2034151574 hasConcept C2779134260 @default.
- W2034151574 hasConcept C2779912601 @default.
- W2034151574 hasConcept C54355233 @default.
- W2034151574 hasConcept C71924100 @default.
- W2034151574 hasConcept C86803240 @default.
- W2034151574 hasConcept C8891405 @default.
- W2034151574 hasConceptScore W2034151574C104317684 @default.
- W2034151574 hasConceptScore W2034151574C137061746 @default.
- W2034151574 hasConceptScore W2034151574C142724271 @default.
- W2034151574 hasConceptScore W2034151574C147483822 @default.
- W2034151574 hasConceptScore W2034151574C19317047 @default.
- W2034151574 hasConceptScore W2034151574C202751555 @default.
- W2034151574 hasConceptScore W2034151574C203014093 @default.
- W2034151574 hasConceptScore W2034151574C2776090121 @default.
- W2034151574 hasConceptScore W2034151574C2777058396 @default.
- W2034151574 hasConceptScore W2034151574C2779134260 @default.
- W2034151574 hasConceptScore W2034151574C2779912601 @default.
- W2034151574 hasConceptScore W2034151574C54355233 @default.
- W2034151574 hasConceptScore W2034151574C71924100 @default.
- W2034151574 hasConceptScore W2034151574C86803240 @default.
- W2034151574 hasConceptScore W2034151574C8891405 @default.
- W2034151574 hasIssue "3" @default.
- W2034151574 hasLocation W20341515741 @default.
- W2034151574 hasLocation W20341515742 @default.
- W2034151574 hasOpenAccess W2034151574 @default.
- W2034151574 hasPrimaryLocation W20341515741 @default.
- W2034151574 hasRelatedWork W1993116843 @default.
- W2034151574 hasRelatedWork W2034151574 @default.
- W2034151574 hasRelatedWork W2360614059 @default.
- W2034151574 hasRelatedWork W2364348052 @default.
- W2034151574 hasRelatedWork W2380447377 @default.
- W2034151574 hasRelatedWork W2384875831 @default.
- W2034151574 hasRelatedWork W2808229450 @default.
- W2034151574 hasRelatedWork W2900225392 @default.
- W2034151574 hasRelatedWork W3048329907 @default.
- W2034151574 hasRelatedWork W4383187108 @default.
- W2034151574 hasVolume "31" @default.
- W2034151574 isParatext "false" @default.
- W2034151574 isRetracted "false" @default.
- W2034151574 magId "2034151574" @default.
- W2034151574 workType "article" @default.