FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034152561> ?p ?o ?g. }

• W2034152561 endingPage "221" @default.
• W2034152561 startingPage "213" @default.
• W2034152561 abstract "In this study, vasoactive intestinal peptide (VIP) is shown to inhibit substrate adherence capacity of rat peritoneal macrophages. The inhibitory response occurred in the 0.1-1,000 nM range of VIP concentrations and it was a time-dependent process. At 15 min, half maximal inhibition (IC50) was obtained at 0.37 +/- 0.26 nM and maximal inhibition (53.8%) at 10(-6) M VIP. The inhibitory effect of VIP was correlated with the stimulation by this peptide of cyclic AMP (cAMP) production in rat peritoneal macrophages. Moreover, agents that inhibited VIP-stimulated cAMP production, such as the VIP-antagonist [4-Cl-D-Phe6, Leu17]-VIP and somatostatin, also decreased the inhibitory effect of VIP on substrate adherence capacity of macrophages. On the contrary, the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX) and the lipid-soluble derivative of cAMP N6,2'-O-dibutyryl cAMP (Bu-cAMP) inhibited the adherence of macrophages to substrate and potentiated the inhibitory action of VIP. These results demonstrate that VIP inhibits substrate adherence capacity of rat peritoneal macrophages by a mechanism that involves cAMP, and show, for the first time, an action of VIP on the function of peritoneal macrophages." @default.
• W2034152561 created "2016-06-24" @default.
• W2034152561 creator A5014386006 @default.
• W2034152561 creator A5017023675 @default.
• W2034152561 creator A5027679925 @default.
• W2034152561 creator A5062431602 @default.
• W2034152561 date "1993-01-01" @default.
• W2034152561 modified "2023-10-03" @default.
• W2034152561 title "Vasoactive Intestinal Peptide (VIP) Inhibits Substrate Adherence Capacity of Rat Peritoneal Macrophages by a Mechanism That Involves cAMP" @default.
• W2034152561 cites W1529606715 @default.
• W2034152561 cites W1595689392 @default.
• W2034152561 cites W1607194119 @default.
• W2034152561 cites W1843625977 @default.
• W2034152561 cites W1915086900 @default.
• W2034152561 cites W1970489693 @default.
• W2034152561 cites W1987329031 @default.
• W2034152561 cites W1988796564 @default.
• W2034152561 cites W2000062730 @default.
• W2034152561 cites W2006037282 @default.
• W2034152561 cites W2014042634 @default.
• W2034152561 cites W2023435121 @default.
• W2034152561 cites W2027689553 @default.
• W2034152561 cites W2029834003 @default.
• W2034152561 cites W2030955628 @default.
• W2034152561 cites W2033481558 @default.
• W2034152561 cites W2033533297 @default.
• W2034152561 cites W2047327922 @default.
• W2034152561 cites W2053325010 @default.
• W2034152561 cites W2062440617 @default.
• W2034152561 cites W2078292904 @default.
• W2034152561 cites W2102395812 @default.
• W2034152561 cites W2127216663 @default.
• W2034152561 cites W2148475004 @default.
• W2034152561 cites W2149837883 @default.
• W2034152561 cites W2155131499 @default.
• W2034152561 cites W2167382976 @default.
• W2034152561 cites W2167687472 @default.
• W2034152561 cites W4254616202 @default.
• W2034152561 cites W79466244 @default.
• W2034152561 doi "https://doi.org/10.3109/15419069309097255" @default.
• W2034152561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7521755" @default.
• W2034152561 hasPublicationYear "1993" @default.
• W2034152561 type Work @default.
• W2034152561 sameAs 2034152561 @default.
• W2034152561 citedByCount "17" @default.
• W2034152561 crossrefType "journal-article" @default.
• W2034152561 hasAuthorship W2034152561A5014386006 @default.
• W2034152561 hasAuthorship W2034152561A5017023675 @default.
• W2034152561 hasAuthorship W2034152561A5027679925 @default.
• W2034152561 hasAuthorship W2034152561A5062431602 @default.
• W2034152561 hasConcept C118303440 @default.
• W2034152561 hasConcept C126322002 @default.
• W2034152561 hasConcept C134018914 @default.
• W2034152561 hasConcept C170493617 @default.
• W2034152561 hasConcept C17077164 @default.
• W2034152561 hasConcept C181199279 @default.
• W2034152561 hasConcept C185592680 @default.
• W2034152561 hasConcept C202751555 @default.
• W2034152561 hasConcept C24998067 @default.
• W2034152561 hasConcept C2776297358 @default.
• W2034152561 hasConcept C2776766087 @default.
• W2034152561 hasConcept C2777752497 @default.
• W2034152561 hasConcept C2779276759 @default.
• W2034152561 hasConcept C2781298581 @default.
• W2034152561 hasConcept C55493867 @default.
• W2034152561 hasConcept C62826618 @default.
• W2034152561 hasConcept C71924100 @default.
• W2034152561 hasConcept C8330315 @default.
• W2034152561 hasConceptScore W2034152561C118303440 @default.
• W2034152561 hasConceptScore W2034152561C126322002 @default.
• W2034152561 hasConceptScore W2034152561C134018914 @default.
• W2034152561 hasConceptScore W2034152561C170493617 @default.
• W2034152561 hasConceptScore W2034152561C17077164 @default.
• W2034152561 hasConceptScore W2034152561C181199279 @default.
• W2034152561 hasConceptScore W2034152561C185592680 @default.
• W2034152561 hasConceptScore W2034152561C202751555 @default.
• W2034152561 hasConceptScore W2034152561C24998067 @default.
• W2034152561 hasConceptScore W2034152561C2776297358 @default.
• W2034152561 hasConceptScore W2034152561C2776766087 @default.
• W2034152561 hasConceptScore W2034152561C2777752497 @default.
• W2034152561 hasConceptScore W2034152561C2779276759 @default.
• W2034152561 hasConceptScore W2034152561C2781298581 @default.
• W2034152561 hasConceptScore W2034152561C55493867 @default.
• W2034152561 hasConceptScore W2034152561C62826618 @default.
• W2034152561 hasConceptScore W2034152561C71924100 @default.
• W2034152561 hasConceptScore W2034152561C8330315 @default.
• W2034152561 hasIssue "3" @default.
• W2034152561 hasLocation W20341525611 @default.
• W2034152561 hasLocation W20341525612 @default.
• W2034152561 hasOpenAccess W2034152561 @default.
• W2034152561 hasPrimaryLocation W20341525611 @default.
• W2034152561 hasRelatedWork W1965764721 @default.
• W2034152561 hasRelatedWork W1975500227 @default.
• W2034152561 hasRelatedWork W1979581036 @default.
• W2034152561 hasRelatedWork W1982310992 @default.
• W2034152561 hasRelatedWork W2016899150 @default.
• W2034152561 hasRelatedWork W2034152561 @default.
• W2034152561 hasRelatedWork W2053661573 @default.

• next