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- W2034156268 abstract "With the use of the whole-cell patch clamp technique, we examined effects of zinc on AMPA receptors of isolated carp retinal horizontal cells, predominantly consisting of flop splice variants. We found that zinc ranging from 30 μM to 1 mM failed to modulate glutamate-induced currents of these cells, which is clearly distinct from the results previously obtained in superior colliculus neurons and Xenopus ooctyes. Furthermore, glutamate responses remained unchanged when zinc was co-applied with PEPA, a flop variant-preferential AMPA receptor potentiator. With the co-application of cyclothiazide, a flip variant-preferential AMPA receptor potentiator, however, a dual effect could be observed: zinc potentiated glutamate responses at low concentrations, but inhibited them at higher concentrations. These results suggest that the action of zinc on AMPA receptors may be splice variant-relevant." @default.
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- W2034156268 date "1999-01-01" @default.
- W2034156268 modified "2023-09-23" @default.
- W2034156268 title "Zinc modulation of AMPA receptors may be relevant to splice variants in carp retina" @default.
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- W2034156268 doi "https://doi.org/10.1016/s0304-3940(98)00938-0" @default.
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