Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034157067> ?p ?o ?g. }
- W2034157067 endingPage "341" @default.
- W2034157067 startingPage "329" @default.
- W2034157067 abstract "Narcolepsy is a sleep disorder that has been shown to be tightly associated with HLA DR15 (DR2). In this study, 58 non-DR15 patients with narco-lepsy-cataplexy were typed at the HLA DRB1, DQA1 and DQB1 loci. Subjects included both sporadic cases and narcoleptic probands from multiplex families. Additional markers studied in the class II region were the promoters of the DQA1 and DQB1 genes, two CA repeat polymorphisms (DQCAR and DQCARII) located between the DQA1 and DQB1 genes, three CA repeat markers (G51152, T16CAR and G411624R) located between DQB1 and DQB3 and polymorphisms at the DQB2 locus. Twenty-one (36%) of these 58 non-DR15 narcoleptic patients were DQA1*0T02 and DQBI*0602, a DQ1 Subtype normally associated with DRB1*15 in DR2-positive narcoleptic subjects. Additional microsatellite and DQA1 promoter diversity was found in some of these non-DR15 but DQB1*0602-positive haplotypes but the known allele specific codons of DQA1*0102 and DQB1*0602 were maintained in all 21 cases. The 37 non-DQA1*0102/DQB1*0602 subjects did not share any particular HLA DR or DQ alleles. We conclude that HLA DQA1*0102 and DQB1*0602 are the most likely primary candidate susceptibility genes for narcolepsy in the HLA class II region." @default.
- W2034157067 created "2016-06-24" @default.
- W2034157067 creator A5000989945 @default.
- W2034157067 creator A5005411506 @default.
- W2034157067 creator A5018034562 @default.
- W2034157067 creator A5022377956 @default.
- W2034157067 creator A5032309111 @default.
- W2034157067 creator A5032547786 @default.
- W2034157067 creator A5034912765 @default.
- W2034157067 creator A5036642361 @default.
- W2034157067 creator A5046285914 @default.
- W2034157067 creator A5048864428 @default.
- W2034157067 creator A5055408082 @default.
- W2034157067 creator A5083832879 @default.
- W2034157067 creator A5087811468 @default.
- W2034157067 date "1997-04-01" @default.
- W2034157067 modified "2023-10-05" @default.
- W2034157067 title "Extensive HLA class II studies in 58 non-DRB1*15 (DR2) narcoleptic patients with cataplexy" @default.
- W2034157067 cites W122113244 @default.
- W2034157067 cites W127014378 @default.
- W2034157067 cites W133305872 @default.
- W2034157067 cites W1554797538 @default.
- W2034157067 cites W1921939902 @default.
- W2034157067 cites W1964502071 @default.
- W2034157067 cites W1971234243 @default.
- W2034157067 cites W1972965316 @default.
- W2034157067 cites W1985838118 @default.
- W2034157067 cites W1986627264 @default.
- W2034157067 cites W1997759379 @default.
- W2034157067 cites W2002033824 @default.
- W2034157067 cites W2003797176 @default.
- W2034157067 cites W2003986231 @default.
- W2034157067 cites W2025537102 @default.
- W2034157067 cites W2032915456 @default.
- W2034157067 cites W2040032939 @default.
- W2034157067 cites W2045036517 @default.
- W2034157067 cites W2050501127 @default.
- W2034157067 cites W2051540127 @default.
- W2034157067 cites W2070307439 @default.
- W2034157067 cites W2071544653 @default.
- W2034157067 cites W2072660684 @default.
- W2034157067 cites W2074567340 @default.
- W2034157067 cites W2082191940 @default.
- W2034157067 cites W2083086230 @default.
- W2034157067 cites W2085761331 @default.
- W2034157067 cites W2086508456 @default.
- W2034157067 cites W2087777800 @default.
- W2034157067 cites W2088754606 @default.
- W2034157067 cites W2109692389 @default.
- W2034157067 cites W2111087512 @default.
- W2034157067 cites W2122043015 @default.
- W2034157067 cites W2134131358 @default.
- W2034157067 cites W2146816378 @default.
- W2034157067 cites W2411075933 @default.
- W2034157067 cites W2419566024 @default.
- W2034157067 cites W4244163133 @default.
- W2034157067 cites W46297728 @default.
- W2034157067 cites W69558267 @default.
- W2034157067 cites W82381281 @default.
- W2034157067 cites W86849667 @default.
- W2034157067 doi "https://doi.org/10.1111/j.1399-0039.1997.tb02761.x" @default.
- W2034157067 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9151385" @default.
- W2034157067 hasPublicationYear "1997" @default.
- W2034157067 type Work @default.
- W2034157067 sameAs 2034157067 @default.
- W2034157067 citedByCount "105" @default.
- W2034157067 countsByYear W20341570672012 @default.
- W2034157067 countsByYear W20341570672013 @default.
- W2034157067 countsByYear W20341570672014 @default.
- W2034157067 countsByYear W20341570672015 @default.
- W2034157067 countsByYear W20341570672016 @default.
- W2034157067 countsByYear W20341570672017 @default.
- W2034157067 countsByYear W20341570672018 @default.
- W2034157067 countsByYear W20341570672019 @default.
- W2034157067 countsByYear W20341570672020 @default.
- W2034157067 countsByYear W20341570672021 @default.
- W2034157067 countsByYear W20341570672022 @default.
- W2034157067 countsByYear W20341570672023 @default.
- W2034157067 crossrefType "journal-article" @default.
- W2034157067 hasAuthorship W2034157067A5000989945 @default.
- W2034157067 hasAuthorship W2034157067A5005411506 @default.
- W2034157067 hasAuthorship W2034157067A5018034562 @default.
- W2034157067 hasAuthorship W2034157067A5022377956 @default.
- W2034157067 hasAuthorship W2034157067A5032309111 @default.
- W2034157067 hasAuthorship W2034157067A5032547786 @default.
- W2034157067 hasAuthorship W2034157067A5034912765 @default.
- W2034157067 hasAuthorship W2034157067A5036642361 @default.
- W2034157067 hasAuthorship W2034157067A5046285914 @default.
- W2034157067 hasAuthorship W2034157067A5048864428 @default.
- W2034157067 hasAuthorship W2034157067A5055408082 @default.
- W2034157067 hasAuthorship W2034157067A5083832879 @default.
- W2034157067 hasAuthorship W2034157067A5087811468 @default.
- W2034157067 hasConcept C104317684 @default.
- W2034157067 hasConcept C147483822 @default.
- W2034157067 hasConcept C16568411 @default.
- W2034157067 hasConcept C169760540 @default.
- W2034157067 hasConcept C180754005 @default.
- W2034157067 hasConcept C188280979 @default.